Xeljanz can cause side effects, which range from mild to serious. It is important to be aware of potential reactions while taking this medication.
Common Side Effects:
These effects are generally mild and may decrease over time. Contact your doctor if they persist.
- Upper respiratory tract infections (common cold, sinus infections)
- Headache
- Diarrhea
- Nasal congestion or sore throat
Serious Side Effects:
Xeljanz includes warnings about serious risks. Seek immediate medical attention if you experience any of the following:
- Serious Infections: Symptoms may include fever, chills, cough, fatigue, or painful skin rash (shingles). There is an increased risk of tuberculosis and fungal infections.
- Blood Clots: Signs include sudden chest pain, shortness of breath, or pain and swelling in a leg.
- Cancer and Lymphoma: Xeljanz may increase the risk of developing certain cancers.
- Low Blood Counts: Your doctor will monitor your blood cell levels.
- Gastrointestinal Perforations: Tears in the stomach or intestines.
Xeljanz is approved to treat adults with several chronic inflammatory and autoimmune conditions, particularly when other treatments like TNF blockers have not been effective.
Approved Indications:
- Rheumatoid Arthritis: For moderately to severely active cases, reducing joint pain and swelling.
- Psoriatic Arthritis: For active cases, helping with joint inflammation and skin plaques.
- Ulcerative Colitis: For moderately to severely active cases, managing inflammation in the large intestine.
- Ankylosing Spondylitis: For active cases, targeting inflammation in the spine.
Common Off-Label Uses:
- Alopecia Areata: To promote hair regrowth by calming the immune attack on hair follicles.
- Other Rheumatic Diseases: Including dermatomyositis and systemic lupus erythematosus.