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For visual reference only; actual product may vary
For visual reference only; actual product may vary
Vagifem is a local estrogen therapy containing estradiol. It directly treats the symptoms of vaginal atrophy brought on by menopause, such as dryness, burning and irritation. By restoring estrogen levels in the vaginal tissue, Vagifem helps relieve discomfort and improves vaginal health for women. For customers in the U.S., a doctor’s prescription is required. In most other countries, Vagifem is sold over-the-counter.
| Vagifem Brand | 10 mcg 24 Suppositories |
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Our price: $86.00 |
 Her Essentials Pack | 30 Pouches 1 Pouch a Day | –+ | Our price: $68.85 |
Vagifem (active ingredient: estradiol) is a natural form of the hormone estrogen that can be used to treat vaginal atrophy in women undergoing menopause. Symptoms such as vaginal dryness, urgency, irritation or burning during urination can be caused by the steady decline of hormone levels.
Vagifem is available over-the-counter (OTC) in some countries, but customers in the U.S. require a prescription.
During menopause, the level of estrogen produced by the body steadily declines. This hormonal decline causes the vaginal walls to become thinner, drier, and less elastic – a condition is known as atrophic vaginitis.
Vagifem works by delivering a low dose of estradiol directly to the vaginal tissues. When applied inside the vagina, Vagifem replenishes estrogen levels locally, without raising the levels throughout the body. Because it acts locally with minimal absorption into the bloodstream, it provides a targeted treatment option.
The increase in local estrogen levels helps restore the thickness and moisture of the vaginal lining. The process reduces inflammation and alleviates symptoms of vaginal atrophy over time.
We also suggest, based on experience, that customers could find that supplementing their diet with the special Her Essentials Pack can increase the effectiveness of the suppositories in the longer term. The ingredents is a blend of probiotics, vitamins, minerals and adaptogens that can promote hormonal balance, boost immune health, and increase overall vitality.
Vagifem is designed solely for postmenopausal females who experience symptoms of vaginal atrophy. A doctor should confirm if Vagifem is a safe and suitable choice for you based on your personal medical history.
Vagifem comes in the form of suppositories that can be easily inserted into the vagina. When use has been prescribed, it is important to follow the prescribing doctor’s instructions and any other specific instructions printed on the label.
Treatment usually begins with an initial phase, which involves inserting one vaginal suppository daily for two weeks. After the initial period, the dose is normally reduced to a maintenance schedule of one suppository inserted twice each week. You should try to space these doses evenly, roughly three days apart – for example, on Mondays and Thursdays. The suppository is meant to be placed using the provided disposable applicator.
If you miss a dose, apply it as soon as you remember if it’s less than 36 hours to the next scheduled dose. Don’t use two doses at once to make up for any misses. Rather skip that dose and return to the regular schedule.
Vagifem vaginal suppositories may be used in women whether or not they have an intact uterus. For women without an intact uterus, progestin treatment is usually required alongside Vagifem.
The patient information leaflet carries full information on reported side effects. Full details are also shown in the Side Effects tab on this page.
In brief, Vagifem may cause mild local side effects, which usually clear up on their own. Common side effects include vaginal pain, dryness, or mild discomfort. Some users may experience slight nausea, swollen breasts, or changes in skin color. More serious side effects but are rare, but require immediate medical attention. Refer to the information leaflet and the Side Effects tab for more details.
IsraelPharm provides access to authentic brand-name pharmaceuticals like Vagifem, sourced directly from licensed manufacturers. Ordering via our streamlined online platform is simple and secure. All orders are delivered discretely directly to your door.
NOTE: U.S. customers must send us a copy of their doctor’s prescription before we can dispense. For customers in most other counties, Vagifem is available over-the-counter without prescription.
This text is for informational purposes only. If you have any questions, please consult a doctor or contact our online support team before using Vagifem
Read the patient information leaflet that comes with the package. There is a special warning in the leaflet that precautions for use exist for patients with Endometrial Hyperplasia and carcinoma.
If after using Vagifem there is a sudden allergic reaction (anaphylaxis), with symptoms like swelling of the face, tongue or throat making it difficult to breathe or swallow, or there is wheezing, hives, rash, blistering or peeling of the skin, call a doctor or 911 right away; or go to an emergency room immediately.
Most people who use Vagifem do not experience any negative side effects.
Some mild side effects have been reported; including:
Rarely, more serious side effects have been reported. These should be reported to a doctor immediately. They include:
Not all side effects are listed here. If these or other unlisted symptoms persist or worsen, consult a healthcare provider or pharmacist.
Vagifem vaginal suppositories are used to treat changes in the vagina (vaginal atrophy) resulting from the decline in levels of the hormone estrogen due to menopause.
The main symptoms of vaginal atrophy caused by low estrogen are:
The only reliable diagnosis comes from a blood test to measure estrogen levels.
Vagifem typically begins to provide relief from symptoms within a few weeks of starting treatment, with many users noticing improvements in vaginal dryness and discomfort. However, the full benefits of the medication may take up to 8 to 12 weeks to become apparent. Consistent use as prescribed by your healthcare provider is key to achieving the best results and maintaining vaginal health over time.
Vagifem can be used by women who have had a hysterectomy, as it is a local estrogen therapy that acts directly on the vaginal tissues and the hormone does not enter the bloodstream. In such cases, there is generally no requirement to also prescribe progestin, which is needed to protect the uterine lining when the uterus is still intact. Always consult your doctor for personalized advice.
Vagifem is administered by the user directly into the vagina using a pre-loaded, single-use applicator that contains one small estradiol suppository. The applicator is designed for easy and hygienic insertion. It is important to follow the specific instructions provided with the medication for proper use and best results.
Vagifem is unlikely to cause significant weight gain because it is a local therapy with minimal absorption into the rest of the body. While systemic hormone replacement therapy is sometimes associated with fluid retention or changes in weight, the very low dose of estradiol in Vagifem primarily affects the vaginal tissue. If you experience unexpected weight changes while using the medication, you should discuss them with your doctor.
Vagifem should not be stored in the refrigerator; it should be kept at room temperature, below 25°C (77°F). It is important to keep the tablets in their original packaging until you are ready to use them to protect them from moisture and light. Always check the expiration date on the package and don't use any suppositories that appear to be discolored or damaged..
While using Vagifem, it is generally considered safe to consume alcohol in moderation. Because Vagifem is applied locally in the vagina and has very low systemic absorption, it is not expected to have a significant interaction with alcohol. It is always best to follow general health guidelines and consult your healthcare provider for personalized advice.
Vagifem comes with a special warning regarding an increased risk of endometrial hyperplasia and carcinoma. This elevated risk is associated with all hormonal estrogen supplements, not just Vagifem. It is crucial to discuss your personal and family medical history, particularly regarding cancer, with your doctor before starting treatment to ensure it is safe for you.
You should discuss the use of other vaginal products, such as lubricants or moisturizers, with your doctor before using them alongside Vagifem. Some products may interfere with the absorption or effectiveness of the medication. Your healthcare provider can recommend products that are safe to use with your treatment and advise on the best timing for application to avoid any potential interactions or reduced efficacy.
Yes, Vagifem is a special form of local hormone replacement therapy (HRT). However, unlike systemic HRT, which circulates throughout the body, Vagifem delivers a very low dose of estradiol directly to the vaginal tissue. This targeted approach helps to specifically address vaginal symptoms of menopause, such as dryness and irritation, with minimal effects on the rest of the body, reducing the risk of certain side effects.
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