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Myrbetriq’s primary use is in the treatment of overactive bladder. Myrbetriq has also recently been shown to activate brown fat and increase metabolism. In a small study of 15 healthy, lean men, Myrbetriq was shown to increase basal heart rate, metabolic rate and blood pressure which are signs of cardiovascular stimulation. Recently, Myrbetriq was shown to relax in vitro human and rabbit prostate smooth muscle through activation of beta3-adrenoceptor. The same group also showed that Myrbetriq promotes smooth muscle relaxation by alpha1-adrenoceptor blockade.
Severe
vasculitis / Delayed / 0-1.0
stroke / Early / 0.4-0.4
atrial fibrillation / Early / 0.2-0.2
ocular hypertension / Delayed / Incidence not known
angioedema / Rapid / Incidence not known
Stevens-Johnson syndrome / Delayed / Incidence not known
new primary malignancy / Delayed / Incidence not known
Moderate
hypertension / Early / 7.5-11.3
constipation / Delayed / 1.6-2.8
cystitis / Delayed / 2.1-2.1
sinus tachycardia / Rapid / 1.2-1.6
palpitations / Early / 0-1.0
gastritis / Delayed / 0-1.0
vaginitis / Delayed / 0-1.0
nephrolithiasis / Delayed / 0-1.0
elevated hepatic enzymes / Delayed / Incidence not known
urinary retention / Early / Incidence not known
hallucinations / Early / Incidence not known
confusion / Early / Incidence not known
blurred vision / Early / Incidence not known
Mild
headache / Early / 2.1-4.1
pharyngitis / Delayed / 3.5-3.9
xerostomia / Early / 2.8-2.8
back pain / Delayed / 2.8-2.8
dizziness / Early / 2.7-2.7
sinusitis / Delayed / 0-2.7
influenza / Delayed / 2.6-2.6
arthralgia / Delayed / 1.3-2.1
diarrhea / Early / 1.2-1.5
abdominal pain / Early / 0.6-1.4
fatigue / Early / 1.2-1.4
dyspepsia / Early / 0-1.0
bladder discomfort / Early / 0-1.0
vaginal irritation / Early / 0-1.0
rhinitis / Early / 0-1.0
purpura / Delayed / 0-1.0
pruritus / Rapid / 0-1.0
urticaria / Rapid / 0-1.0
rash / Early / 0-1.0
nausea / Early / 0.4-0.4
infection / Delayed / Incidence not known
anxiety / Delayed / Incidence not known
insomnia / Early / Incidence not known
xerophthalmia / Early / Incidence not known
Symptomatic treatment of urgency, increased micturition frequency and/or urgency incontinence as may occur in adult patients with overactive bladder (OAB) syndrome.
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