Along with its needed effects, apixaban (the active ingredient contained in Eliquis) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking Apixaban: Blood in the eyes, blood in the urine, bloody or black, tarry stools. Bruising or purple areas on the skin, confusion, constipation, coughing up blood, decreased alertness, difficulty swallowing, dizziness, fainting, fast heartbeat, headache, hives, itching, joint pain or swelling, nausea and vomiting, nosebleeds, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. Redness of the eye. Severe stomach pain, shortness of breath, skin rash, tightness in the chest, unusual tiredness or weakness, vomiting of blood or material that looks like coffee grounds.
Eliquis (apixaban) is a blood thinner medicine that reduces blood clotting and reduces the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Eliquis belongs to a class of medicines called anticoagulant medications.
CYP3A4 inhibitor drugs such as Serzone, Sporanox, Nizoral, Vfend, Reyataz, Biaxan and Ketek should not be taken while a patient is taking Eliquis. Patients may have a higher risk of bleeding if Eliquis is taken alongside other medicines that increase the risk of bleeding, such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin (Coumadin), heparin, selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), and other medicines to help prevent or treat blood clots.