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  • US Name:

    Wellbutrin XL

  • Generic Names:

    Wellbutrin XR

  • Active Ingredients:


  • Brand Manufacturer:


  • Manufacturer Location:


  • Click here to view Product Insert

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Wellbutrin XL

Prescription Required

Wellbutrin is primarily used as an atypical antidepressant and smoking cessation aid.

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Wellbutrin XR Brand 150 mg
30 Tablets
Our price: $50.00
Wellbutrin XR Brand 300 mg
30 Tablets
Our price: $75.00

*Please note all prices are in US dollars
Wellbutrin (generic: bupropion) is prescribed to treat some forms of depression. It is mainly used to treat only adults diagnosed with Major Depressive Disorder (MDD) and seasonal affective disorder (SAD). Bupropion is classified as an atypical antidepressant. It is most commonly used in cases of an inadequate response to the first choice of selective serotonin reuptake inhibitor (SSRI) antidepressants. Its mode of action is to increase the levels of dopamine and norepinephrine in the brain. Bupropion can also be prescribed off-label to treat the symptoms of depression in people diagnosed with bipolar disorder or Attention-deficit/Hyperactivity Disorder (ADHD), and erectile dysfunction caused by treatment with SSRI antidepressants. “Off-label” means that the Food and Drug Administration has not approved it for these conditions, but a doctor can recommend this treatment. It may take some before the medicine has its full effect, is some cases up to several months. When the benefits are starting to be felt, the prescribing doctor may advise you to keep taking Wellbutrin XR to prevent recurrence of the depression.


Take Wellbutrin exactly as prescribed. The usualy recommended dosage is one 150 mg tablet, once daily in the morning. The dosage may be increased to 300 mg once daily if the feelings of depression do not improve after several weeks. Take the scheduled dose with or without food at approximately the same time each day. It must only be taken once each day, in the morning. Swallow the tablets whole. Do not chew, crush or split them. This can cause the medicine to be released too quickly and can produce unwanted side effects. If a scheduled dose has been missed, take the next dose at the usual time. Do not double-dose to make up for a forgotten dose.  

This text is for informational purposes only. Please consult your doctor or pharmacist before using any medication.

Please read the Product Insert that comes with the medication.

Some mild side effects may be felt. Ask your doctor or pharmacist for advice if you feel depressed, anxious, dizzy, or have difficulty concentrating.

Other side effects include:

  • Tremors
  • Headaches
  • Nausea or vomiting
  • Abdominal pain
  • Constipation
  • Changes in the taste of food
  • Dry mouth
  • Fever
  • Sweating
  • Allergic skin rash
  • Itching.

Not all side effects are listed here. If these or any other unexpected effects are experienced, and persist of worsen, consult with a healthcare provider or pharmacist as soon as possible.

Wellbutrin XR is indicated for the treatment of major depressive episodes in people diagnosed with Major Depressive Disorder (MDD) and seasonal depressive disorder (SAD).

The main symptoms in people diagnosed with Major Depressive Disorder (MDD) include:

  • Depressed mood – feeling sad, empty, or tearful
  • Feeling of worthlessness, guilty hopelessness, or helplessness
  • Loss of interest or pleasure in everyday activities
  • Loss of ability to sleep
  • Changes in appetite (most people eat more than usual, but it can also be loss of appetite)
  • Low energy, trouble concentrating, or thoughts of death (suicidal thinking)
  • Agitation
  • Psychomotor retardation
  • Suicidal thoughts.

Seasonal affective disorder is a type of depression that follows a seasonal pattern, typically worsening in the fall and winter months. It is believed to be linked to low levels of sunlight, which can disrupt the body’s internal clock (circadian rhythm,) leading to feelings of depression.

Symptoms of seasonal affective disorder can vary from mild to severe and often include:

  • Feelings of depression, sadness, hopelessness, and despair.
  • Development of noticeable disinterest in activities that were once enjoyed.
  • Cravings for carbohydrates, which results in weight gain.
  • Insomnia
  • Oversleeping, missing deadlines, and skipping routine scheduled tasks.
  • Lower energy and increased fatigue.
  • Difficulty concentrating, focusing, or making decisions.
  • Restlessness or irritability.
  • Feelings of worthlessness or guilt.
  • Complaints of headaches, stomach problems, and joint or muscle pain.

Following a satisfactory response, continuation with Wellbutrin XR therapy is effective in preventing relapse.

  • Does bupropion burn fat?
    Wellbutrin (generic name: bupropion) is an antidepressant that has been utilized to facilitate weight loss. Unlike other antidepressants that have not demonstrated a comparable effect, clinical trials have reported reductions in body weight for patients taking Wellbutrin. The precise way in which bupropion stimulates weight loss remains uncertain, but researchers propose that it may impact neurotransmitters in the brain, which could potentially affect metabolism and appetite.
  • Does bupropion increase or decrease dopamine?
    Bupropion (Wellbutrin) is unique among antidepressants, acting to inhibit dopamine reuptake. This leads to increases in dopamine levels at synapses. This has led to its use as a therapy to treat major depressive episodes, for which it is most commonly prescribed.
  • Is bupropion a serotonin or dopamine?
    Wellbutrin selectively inhibits the reuptake of noradrenaline and dopamine (catecholamines) in neurons. It has only a minimal effect on the reuptake of serotonin (indoleamine). It has no effect on monoamine oxidase.This constitutes a novel mechanism of antidepressant action.
  • Does caffeine affect bupropion?
    The potential side effects of bupropion may be made worse if an individual consumes large amounts of caffeine. These side effects can include nervousness, irritability, difficulty falling and staying asleep, elevated blood pressure, tremors, or seizures. Therefore, it is advised to limit caffeine intake while taking bupropion to minimize the risk of aggravating these side effects.
  • Does Wellbutrin affect testosterone?
    In some studies, bupropion treatment was found to cause increases in testosterone levels. Compared to other antidepressants that are known to affect serotonergic function, sexual dysfunction is four to six times more likely to occur with them compared with bupropion, which scores the lowest risk of sexual dysfunction.

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