• US Name:

    Prolia, Xgeva

  • Israeli Names:

    Prolia, Xgeva

  • Active Ingredients:


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Prolia, Xgeva

Denosumab (Prolia) and Xgeva are used to prevent Osteoporosis.

Brand Xgeva 120mg1 Vial 20069Amgen 1252
BrandProlia60mg1 Vial3486Amgen1251
  • Description
  • Side Effects
  • Indications

Prolia (active ingredient: denosumab) is a monoclonal antibody that functions to help reduce the effects of bone loss in men and women.

The medication is available as an injection. Apart from reducing osteoporosis, the drug also improves bone mass and strength in users – especially those recovering from some form of cancer. Prolia particularly treats osteoporosis (bone loss) in people who have a high risk of developing sprains and fractures.

Prolia is currently available to adults and children over the age of four. It is primarily prescribed to people with underlying bone conditions, people who develop bone cancer or osteoporosis, and women going through menopause.


Possible side effects of Prolia include:

  • low calcium levels (especially if you have kidney problems)
  • weakness
  • constipation
  • back pain
  • muscle pain
  • pain in your arms and legs
  • anemia
  • diarrhea
  • skin problems (eczema, blisters, dry skin, peeling, redness, itching, small bumps)

You may also be more likely to get a serious infection, such as skin, ear, stomach/gut, or bladder infection while taking Prolia.

Tell your doctor if you develop signs of infection while taking the medication, such as:

  • fever/chills, night sweats
  • red/swollen/tender/warm skin
  • severe stomach or abdominal pain
  • ear pain or drainage, trouble hearing
  • frequent/painful/burning urination, or pink/bloody urine
  • severe itching, burning, rash, blistering, peeling, or dryness of the skin
  • cough or shortness of breath
  • pinpoint purple or red spots under your skin
  • flu symptoms
  • weight loss

Consult your doctor if you experience any of these side effects.

Prolia is used to treat the following conditions:

  • Osteoporosis in postmenopausal women and men who have an increased risk of fracture (broken bones), reducing the risk of spinal, non-spinal and hip fractures
  • Bone loss that results from a reduction in hormone (testosterone) level caused by surgery or treatment with medicines in patients with prostate cancer
  • Bone loss associated with long-term systemic glucocorticoid therapy, in adult patients at high risk of fracture


Prolia is available as an injection and requires a prescription. Please follow your doctor’s instructions when taking this and any medication.


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