Possible side effects of Prolia include:
- low calcium levels (especially if you have kidney problems)
- weakness
- constipation
- back pain
- muscle pain
- pain in your arms and legs
- anemia
- diarrhea
- skin problems (eczema, blisters, dry skin, peeling, redness, itching, small bumps)
You may also be more likely to get a severe infection, such as skin, ear, stomach/gut, or bladder infection, while taking Prolia/Xgeva.
Inform a doctor immediately if there are signs of infection while taking the medication, such as:
- fever/chills, night sweats
- red/swollen/tender/warm skin
- severe stomach or abdominal pain
- ear pain or drainage, trouble hearing
- frequent/painful/burning urination, or pink/bloody urine
- severe itching, burning, rash, blistering, peeling, or dryness of the skin
- cough or shortness of breath
- pinpoint purple or red spots under your skin
- flu symptoms
- weight loss
Not all possible side effects can be listed here. If you experience any of these or other unexpected side effects, consult a healthcare provider immediately.
Prolia is one form of the generic drug denosumab. It has been approved for the reduction of the risks of bone fractures in people with:
- Postmenopausal osteoporosis (especially spinal and hip fractures)
- Osteoporosis in men treated with surgery or medication for prostate cancer with resulting androgen deprivation
- Bone loss associated with long-term systemic glucocorticoid therapy
- Bone loss in women with breast cancer due to aromatase inhibitor-induced estrogen depletion (low estrogen levels)
Xgeva is also a form of denosumab. It is used to prevent fractures, spinal cord compressions, or the need for radiation or surgery to the bone in patients with multiple myeloma or with metastases from solid and giant cell tumors of the bone in adults and adolescents. It is used mainly for patients who cannot be treated by surgery.