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  • US Name:

    Prolia, Xgeva

  • Israeli Names:

    Prolia, Xgeva

  • Active Ingredients:

    Denosumab

  • Brand Manufacturer:

    Amgen

  • Manufacturer Location:

    Netherlands

  • Click here to view Product Insert

Prolia, Xgeva

Denosumab (Prolia) and Xgeva are used to prevent Osteoporosis.

Prolia
Brand		 60mg
1 Vial		 $480.00
Xgeva
Brand		 120mg
1 Vial		 $867.00
*Please note all prices are in US dollars

Prolia (active ingredient: denosumab) is a monoclonal antibody that functions to help reduce the effects of bone loss in men and women.

The medication is available as an injection. Apart from reducing osteoporosis, the drug also improves bone mass and strength in users – especially those recovering from some form of cancer. Prolia particularly treats osteoporosis (bone loss) in people who have a high risk of developing sprains and fractures.

Prolia is currently available to adults and children over the age of four. It is primarily prescribed to people with underlying bone conditions, people who develop bone cancer or osteoporosis, and women going through menopause.

 

Possible side effects of Prolia include:

  • low calcium levels (especially if you have kidney problems)
  • weakness
  • constipation
  • back pain
  • muscle pain
  • pain in your arms and legs
  • anemia
  • diarrhea
  • skin problems (eczema, blisters, dry skin, peeling, redness, itching, small bumps)

You may also be more likely to get a serious infection, such as skin, ear, stomach/gut, or bladder infection while taking Prolia.

Tell your doctor if you develop signs of infection while taking the medication, such as:

  • fever/chills, night sweats
  • red/swollen/tender/warm skin
  • severe stomach or abdominal pain
  • ear pain or drainage, trouble hearing
  • frequent/painful/burning urination, or pink/bloody urine
  • severe itching, burning, rash, blistering, peeling, or dryness of the skin
  • cough or shortness of breath
  • pinpoint purple or red spots under your skin
  • flu symptoms
  • weight loss

Consult a healthcare provider if you experience any of these side effects.

Please be aware that not all possible side effects can be listed here. If you experience any of these or any other unexpected side effects, consult with a healthcare provider immediately.

Prolia is used to treat the following conditions:

  • Osteoporosis in postmenopausal women and men who have an increased risk of fracture (broken bones), reducing the risk of spinal, non-spinal and hip fractures
  • Bone loss that results from a reduction in hormone (testosterone) level caused by surgery or treatment with medicines in patients with prostate cancer
  • Bone loss associated with long-term systemic glucocorticoid therapy, in adult patients at high risk of fracture

 

Prolia is available as an injection and requires a prescription. Please follow your doctor’s instructions when taking this and any medication. As well, failure to read and follow the information on the manufacturer’s Product Insert leaflet that comes with the medication can carry serious health risks. 

  • Can Prolia rebuild bone?

    Can Prolia rebuild bone?
    In clinical trials, Prolia helped to strengthen bone and increase bone mass. It also helped to reduce the incidence of vertebral, nonvertebral, and hip fractures in postmenopausal women with osteoporosis.

  • When should the use of denosumab be avoided?

    When should the use of denosumab be avoided?
    Denosumab may cause some harm to a fetus. Advising the prescribing doctor of the possibility of pregnancy during the course of treatment is very important. Prolia has been reported as causing a severe condition of the jaw bone known as osteonecrosis of the jaw (ONJ). If dental surgery or treatment is scheduled while receiving this medication, the responsible healthcare professional should be informed in advance that this medication is currently being used.

  • What precautions are necessary when being treated with denosumab?

    What precautions are necessary when being treated with denosumab?
    The prescribing doctor should be aware of all other medications being taken (including over-the-counter drugs, vitamins, or herbal remedies). It’s crucial to not take aspirin or products containing it unless the doctor is aware and permits it.

  • Is pregnancy allowed while being treated with denosumab?

    Is pregnancy allowed while being treated with denosumab?
    The prescribing healthcare professional must be made aware before starting this treatment if you are pregnant or planning to become pregnant. Use of denosumab is permitted only if the benefit to the mother outweighs the risk to the fetus. Otherwise, both men and women should avoid conception while taking denosumab. The use of barrier methods of contraception, such as condoms, is recommended.

  • Is denosumab allowed while breastfeeding?

    Is denosumab allowed while breastfeeding?
    It is not yet known whether denosumab is excreted into human milk. Because there may be a potential for severe adverse reactions in infants from denosumab, the decision should be to either discontinue nursing or discontinue the drug while taking into account the importance of denosumab to the mother.
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  • Can Prolia rebuild bone?

    In clinical trials, Prolia helped to strengthen bone and increase bone mass. It also helped to reduce the incidence of vertebral, nonvertebral, and hip fractures in postmenopausal women with osteoporosis.

  • When should the use of denosumab be avoided?

    Denosumab may cause some harm to a fetus. Advising the prescribing doctor of the possibility of pregnancy during the course of treatment is very important. Prolia has been reported as causing a severe condition of the jaw bone known as osteonecrosis of the jaw (ONJ). If dental surgery or treatment is scheduled while receiving this medication, the responsible healthcare professional should be informed in advance that this medication is currently being used.

  • What precautions are necessary when being treated with denosumab?

    The prescribing doctor should be aware of all other medications being taken (including over-the-counter drugs, vitamins, or herbal remedies). It’s crucial to not take aspirin or products containing it unless the doctor is aware and permits it.

  • Is pregnancy allowed while being treated with denosumab?

    The prescribing healthcare professional must be made aware before starting this treatment if you are pregnant or planning to become pregnant. Use of denosumab is permitted only if the benefit to the mother outweighs the risk to the fetus. Otherwise, both men and women should avoid conception while taking denosumab. The use of barrier methods of contraception, such as condoms, is recommended.

  • Is denosumab allowed while breastfeeding?

    It is not yet known whether denosumab is excreted into human milk. Because there may be a potential for severe adverse reactions in infants from denosumab, the decision should be to either discontinue nursing or discontinue the drug while taking into account the importance of denosumab to the mother.
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