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  • US Name:

    Prolia, Xgeva

  • Israeli Names:

    Prolia, Xgeva

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Prolia, Xgeva

Denosumab (Prolia) and Xgeva are used to prevent osteoporosis.

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1 Vial
1 Vial
*Please note all prices are in US dollars

Prolia is one form of the generic drug denosumab. It is a human monoclonal antibody for osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumors of bone.

Xgeva is also a form of denosumab. It prevents complications in adults with advanced cancer that has spread to the bone.


Prolia is administered as an injection by professional healthcare providers. Please follow the doctor’s instructions and read the information on the manufacturer’s Product Insert leaflet that comes with the medication. Denosumab can carry serious health risks.

Possible side effects of Prolia include:

  • low calcium levels (especially if you have kidney problems)
  • weakness
  • constipation
  • back pain
  • muscle pain
  • pain in your arms and legs
  • anemia
  • diarrhea
  • skin problems (eczema, blisters, dry skin, peeling, redness, itching, small bumps)


You may also be more likely to get a severe infection, such as skin, ear, stomach/gut, or bladder infection, while taking Prolia/Xgeva.


Inform a doctor immediately if there are signs of infection while taking the medication, such as:

  • fever/chills, night sweats
  • red/swollen/tender/warm skin
  • severe stomach or abdominal pain
  • ear pain or drainage, trouble hearing
  • frequent/painful/burning urination, or pink/bloody urine
  • severe itching, burning, rash, blistering, peeling, or dryness of the skin
  • cough or shortness of breath
  • pinpoint purple or red spots under your skin
  • flu symptoms
  • weight loss


Not all possible side effects can be listed here. If you experience any of these or other unexpected side effects, consult a healthcare provider immediately.

Prolia is one form of the generic drug denosumab. It has been approved for the reduction of the risks of bone fractures in people with:

  • Postmenopausal osteoporosis (especially spinal and hip fractures)
  • Osteoporosis in men treated with surgery or medication for prostate cancer with resulting androgen deprivation
  • Bone loss associated with long-term systemic glucocorticoid therapy
  • Bone loss in women with breast cancer due to aromatase inhibitor-induced estrogen depletion (low estrogen levels)


Xgeva is also a form of denosumab. It is used to prevent fractures, spinal cord compressions, or the need for radiation or surgery to the bone in patients with multiple myeloma or with metastases from solid and giant cell tumors of the bone in adults and adolescents. It is used mainly for patients who cannot be treated by surgery.

  • Can Prolia rebuild bone?

    In clinical trials, Prolia helped to strengthen bone and increase bone mass. It also helped to reduce the incidence of vertebral, nonvertebral, and hip fractures in postmenopausal women with osteoporosis.
  • When should the use of denosumab be avoided?

    Denosumab may cause some harm to a fetus. Advising the prescribing doctor of the possibility of pregnancy during the course of treatment is very important. Prolia has been reported as causing a severe condition of the jaw bone known as osteonecrosis of the jaw (ONJ). If dental surgery or treatment is scheduled while receiving this medication, the responsible healthcare professional should be informed in advance that this medication is currently being used.
  • What precautions are necessary when being treated with denosumab?

    The prescribing doctor should be aware of all other medications being taken (including over-the-counter drugs, vitamins, or herbal remedies). It’s crucial to not take aspirin or products containing it unless the doctor is aware and permits it.
  • Is pregnancy allowed while being treated with denosumab?

    The prescribing healthcare professional must be made aware before starting this treatment if you are pregnant or planning to become pregnant. Use of denosumab is permitted only if the benefit to the mother outweighs the risk to the fetus. Otherwise, both men and women should avoid conception while taking denosumab. The use of barrier methods of contraception, such as condoms, is recommended.
  • Is denosumab allowed while breastfeeding?

    It is not yet known whether denosumab is excreted into human milk. Because there may be a potential for severe adverse reactions in infants from denosumab, the decision should be to either discontinue nursing or discontinue the drug while taking into account the importance of denosumab to the mother.


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