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Amitriptyline works by preventing serotonin and noradrenaline from being reabsorbed back into the nerve cells in the brain. This helps prolong the mood lightening effect of any released noradrenaline and serotonin. In this way, amitriptyline helps relieve depression. Amitriptyline can cause side effects such as drowsiness. This means it may be useful in treating depression in people who are also anxious and agitated, or who are suffering from disturbances in sleep.
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