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Vortioxetine is indicated for the treatment of major depressive disorder in adults.


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Vortioxetine Brand 5mg
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Vortioxetine is used to treat major depressive disorder in adults. It is an SSRI (selective serotonin reuptake inhibitor) and serotonin receptor modulator that helps restore the serotonin balance in the brain. Low serotonin levels can cause depression, anxiety, mania and other mental health conditions. Vortioxetine works to block serotonin reuptake. It differs from other SSRIs by directly modulating various serotonin receptors.


Follow the directions on the prescription label. Use the medicine exactly as directed. Vortioxetine can be taken with or without food. Do not double dose the next day if a dose was wholly forgotten. Don’t alter the dosage without consulting a healthcare provider, even if the symptoms seem to have gone away. Please read the manufacturer’s Product Insert leaflet that comes with the medication before using it.

A common side effect of vortioxetine is nausea, which has an incidence of 32% in patients who receive a dose of at least 15 milligrams.

Generally, the nausea is usually transient, dose-related and more common in women and during the first week of treatment.

Other common side effects include vomiting, diarrhea, dry mouth, headaches, sexual dysfunction, and abnormal dreams. Studies of sexual dysfunction with vortioxetine show that it was not higher than placebo and lower than other SSRIs or SNRIs.

If these side effects persist or worsen, consult a pharmacist or healthcare provider.

There is also the possibility of more severe side effects. If any of the following occur, inform a doctor right away:

  • shaking (tremor)
  • restlessness
  • inability to keep still
  • changes in sexual ability or decreased interest in sex
  • numbness/tingling
  • easy bleeding or bruising
  • difficulty concentrating or memory changes
  • confusion
  • weakness.

Severe side effects can include seizures, black stools, vomit that looks like coffee grounds, and eye problems such as pain, swelling, redness, dilated pupils or vision changes. These need immediate medical attention.

Increasing levels of serotonin can very rarely cause serotonin sickness. Seek immediate help or go directly to an emergency room if any of the following signs occur:

  • fast heartbeat
  • hallucinations
  • loss of coordination
  • severe dizziness
  • severe nausea, vomiting or diarrhea
  • twitching muscles
  • unexplained fever
  • unusual agitation or restlessness.


Please note that not all possible side effects can be listed. If you experience any of these or any other unexpected side effects, seek medical attention promptly. 

Vortioxetine can be prescribed for the treatment of major depressive disorder in adults. It corrects low levels of serotonin in the brain. Serotonin is a neurotransmitter that enables messages to cross between neurons at synapses (nerve junctions). Low levels of serotonin are a major cause of mental health problems such as depression and anxiety.

Symptoms of general depression include:

  • appetite changes
  • fatigue
  • loss of interest in activities
  • trouble sleeping, thinking, focusing, or making decisions
  • feelings of guilt or worthlessness, sadness or a depressed mood
  • thoughts of suicide or death
  • trouble sleeping
  • weight loss or gain

Before diagnosing the condition as general depression, doctors will rule out other conditions that can present similar symptoms, such as bipolar disorder, anemia, anxiety (although anxiety is sometimes a symptom of depression and many people have both depression and anxiety), ADHD, chronic fatigue syndrome (CFS), cyclothymic disorder (mild  bipolar disorder), diabetes, fibromyalgia, hypercalcemia, hypothyroidism, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD) and vitamin D deficiency.

Doctors who want to confirm a diagnosis of depression, or rule out other possibilities, can order a blood test of serotonin levels, although this test is normally done when carcinoid syndrome is suspected.

  • Is vortioxetine used for bipolar?
    Vortioxetine is prescribed as a first-line therapy to treat major depressive disorder (MDD). For patients with bipolar disorder, doctors can prescribe vortioxetine to address the depressive phase. Doctors will usually prescribe that it must be taken together with a mood stabilizer. Vortioxetine may cause mood changes in people with bipolar disorder, so a doctor may monitor more often for mood changes while taking Vortioxetine.
  • Is vortioxetine a mood stabilizer?
    Vortioxetine is what is known as a selective serotonin reuptake inhibitor (SSRI) and serotonin receptor modulator. It addresses major depressive disorder (MDD) and does not work the same way as lithium in treating bipolar disorder.
  • Can vortioxetine cause mania?
    Very few cases were reported where bouts of mania were directly attributable to Vortioxetine. However, it does not address mania or hypomania in bipolar disorder, so doctors usually prescribe medication along with Vortioxetine to control those phases of bipolar.
  • Does vortioxetine affect concentration?
    Studies on patients with Alzheimer’s disease showed that Vortioxetine produced improved cognitive function. Some other studies on adult patients with acute MDD showed that Vortioxetine had boosted their processing speed. It is believed that improving the balance of brain chemicals called neurotransmitters, that affect mood and emotions, also improves concentration.
  • Can you mix Vortioxetine with alcohol?
    When on a course of vortioxetine, it is essential to restrict alcohol intake. They both affect cerebral functions and can cause impairment when consumed together. Most doctors recommend avoiding alcohol altogether when taking Vortioxetine because it may also increase the risk of side effects.

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