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Rinvoq can be prescribed for adults with rheumatoid or psoriatic arthritis, ulcerative colitis, Crohn’s Disease, ankylosing spondylitis, or active non-radiographic axial spondyloarthritis. It can also be prescribed for adults and children over twelve with atopic dermatitis.

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Rinvoq (generic name: upadacitinib) is an oral medication that can be prescribed for adults with one of the following conditions if treatment with a TNF (tumor necrosis factor) blocker has been tried, and it either did not work well or could not be tolerated:

  • moderate to severe rheumatoid arthritis (RA)
  • refractory, severe, or extensive Crohn’s Disease (approved by the FDA in April, 2023)
  • active psoriatic arthritis (PsA)
  • moderate to severe ulcerative colitis (UC)
  • active ankylosing spondylitis (AS)
  • active non-radiographic axial spondyloarthritis (nr-axSpA)


As well, it can be prescribed for adults and children over the age of 12 with moderate to severe eczema (atopic dermatitis) that did not respond to previous treatment and whose eczema is not well controlled with other pills or injections,

Price comparison

The US retail price for Rinvoq 15 mg is $315 per dose. Some retail chains offer discounted prices of between $199 and $210  for each 15 mg dose. Our price here at IsraelPharm for the same drug is $32 per tablet, delivered to your door at no extra charge!

Before starting to use, read the manufacturer’s Product Insert that comes with the medication. Please note that not all side effects can be listed here. Consult a healthcare provider if you experience any of these or other unexpected side effects.

Some of the reported milder side effects include upper respiratory tract infections like a common cold or sinus infection, cough or bronchitis; shingles or cold sores; nausea, fever or headache; acne or mild allergic reactions, inflammation of hair follicles; abdominal pain or muscle pain. In general, these should pass within a few days. If they persist or get worse, report this to your healthcare provider or pharmacist immediately.

Rinvoq may cause serious side effects, including:

  • Reduced resistance to infections. Serious infections have been reported, including tuberculosis (TB). Your healthcare provider should test you for TB before starting Rinvoq and you should be checked during treatment with Rinvoq. You should not begin treatment with Rinvoq if you have any kind of active infection without the approval of your healthcare provider and if you get a serious infection, report this immediately to your healthcare provider, who may stop your treatment until your infection is controlled. 
  • For people 50 years and older who have at least one cardiovascular risk factor, there is an increased risk of major CV events, such as blood clots, heart attack, stroke, or death. Symptoms of a heart attack include  
    • Discomfort in the center of your chest that lasts for more than a few minutes or that goes away and comes back
    • Severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw
    • Pain or discomfort in your arms, back, neck, jaw, or stomach
    • Shortness of breath with or without chest discomfort
    • Breaking out in a cold sweat
    • Nausea or vomiting
    • In case of a stroke, the symptoms can include feeling lightheaded, feeling weakness in one part or on one side of your body and slurred speech
  • Rinvoq may increase your risk of certain cancers, including lymphoma and skin cancers. Current or past smokers are at higher risk. Follow your healthcare provider’s advice about having your skin checked for skin cancer during treatment with Rinvoq. Limit the amount of time you spend in sunlight. Wear protective clothing when you are in the sun for prolonged periods, and use sunscreen.
  • Reactions such as hives, difficult breathing, feeling faint or dizzy, or swelling of your lips, tongue, or throat may mean you are having an allergic reaction. If any of these symptoms occur during treatment with Rinvoq, stop taking the drug immediately and get emergency medical help.

Risk factors

Tell your healthcare provider if you are being treated for an infection, have a persistent  infection, or have symptoms of an infection, such as:

  • Fever, sweating, or chills
  • Shortness of breath
  • Warm, red, or painful skin or sores on your body
  • Muscle aches
  • Feeling tired
  • Blood in your phlegm
  • Diarrhea or stomach pain
  • Cough
  • Weight loss
  • Burning when urinating or urinating more often than normal

As well, be sure to inform your healthcare provider if you:

  • Are taking medicines for fungal or bacterial infections, rifampicin or phenytoin or medicines that affect your immune system
  • Have TB or have been in close contact with someone with TB
  • Are a current or past smoker
  • Have had a heart attack, other heart problems, or stroke
  • Have or have had any type of cancer, hepatitis B or C, shingles (herpes zoster), blood clots in the veins of your legs or lungs, diverticulitis or ulcers in your stomach or intestines
  • Have other medical conditions, including liver problems, low blood cell counts, diabetes, chronic lung disease, HIV, or a weak immune system
  • Live, have lived, or have traveled to parts of the country, such as the Ohio and Mississippi River valleys and the Southwest, that increase your risk of getting certain kinds of fungal infections
  • Have recently received or are scheduled to receive a vaccine. People who take Rinvoq should not receive live vaccines
  • Are pregnant or plan to become pregnant. Based on animal studies, Rinvoq may harm your unborn baby. Your healthcare provider will check whether or not you are pregnant before you start Rinvoq. You should use effective birth control to avoid becoming pregnant during treatment with Rinvoq and for four weeks after your last dose
  • Are you breastfeeding or plan to breastfeed. Rinvoq may pass into your breast milk. Do not breastfeed during treatment with Rinvoq and for six days after your last dose.

Rinvoq acts on the immune system and is used to treat adults whose condition cannot be controlled adequately with disease-modifying anti-rheumatic medicines (DMARDs) or if the patient does not improve after treatment with a TNF (tumor necrosis factor) blocker or it could not be tolerated:. The conditions include:

  • moderate to severe rheumatoid arthritis. It can be used on its own or along with methotrexate
  • active psoriatic arthritis (inflammation of the joints associated with psoriasis, which shows up as red, scaly patches on the skin). Rinvoq can be used on its own or with methotrexate
  • active axial spondyloarthritis (inflammation of the spine causing back pain), including ankylosing spondylitis
  • non-radiographic axial spondyloarthritis, when there are clear signs of inflammation but X-ray does not show disease
  • moderately to severely active ulcerative colitis and Crohn’s Disease. These are diseases that causes inflammation and ulcers in the lining of the bowel and which in the case of Crohn’s Disease can spread throughout the body.


As well, adults and children from 12 years of age with moderate to severe atopic dermatitis (also known as eczema, when the skin is itchy, red and dry) can be treated with oral medication or by injection.

Rinvoq is approved only when other medicines, including biological medicines, do not or no longer work, or if the patient cannot take them.

How is Rinvoq used?

Rinvoq is available in tablet form and can only be obtained with a prescription. Treatment with the medicine should be supervised by a healthcare provider experienced in diagnosing and treating the conditions for which Rinvoq is used.

For rheumatoid arthritis, axial spondyloarthritis and psoriatic arthritis the recommended dose of Rinvoq is 15 mg once each day. For atopic dermatitis, the dose is calculated according to the patient’s age and the severity of the disease. 

Treatment for ulcerative colitis and Crohn’s Disease is divided into separate induction and maintenance phases, and the dose depends on the phase, the patient’s age and response to treatment, the severity of the disease and any other medication the patient may be taking. In the case of a flare-up of Crohn’s Disease, the dosage may have to be adjusted accordingly by the prescribing physician.

How does Rinvoq work?

In patients with rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, atopic dermatitis, Crohn’s Disease and ulcerative colitis the immune system attacks healthy tissue, causing inflammation, pain and other symptoms.

Rinvoq’s active ingredient upadacitinib is a selective Janus kinase (JAK) inhibitor targeting the JAK1 enzyme that reduces the activity of the immune system. Upadacitinib works to block the action of enzymes that are involved in setting up processes that lead to inflammation, and by blocking their effect, it brings symptoms of the conditions under control.

  • What are the main conditions that upadacitinib can be prescribed for?
    Rinvoq (upadacitinib) can be prescribed to treat rheumatoid arthritis, psoriatic arthritis, eczema, ulcerative colitis, Crohn's disease, ankylosing spondylitis, and non-radiographic axial spondyloarthritis. There are currently no generic alternatives to Rinvoq
  • How long does Rinvoq take to work for rheumatoid arthritis?
    Rinvoq works quickly, showing benefits within as little as one week for some people. It will help to relieve the pain, swelling, and stiffness associated with rheumatoid arthritis. The majority of people taking Rinvoq showed significantly improved symptoms at 12 weeks.
  • Does Rinvoq work better than methotrexate?
    In trials, more than half of the individuals treated with a dose of Rinvoq were still responding to treatment at after 12 weeks. This compared with just over a quarter of those who were treated with methotrexate. This study demonstrates that Rinvoq is more effective than methotrexate in the treatment of RA.
  • Does Rinvoq repair the colon lining for people with Crohn's Disease or ulcerative colitis??
    Treating UC or Crohn's Disease Rinvoq once each day produced rapid relief from UC symptoms as early as two weeks after start, reducing the frequency of bowel movements and the amount of bloody stools. For both Crohn's and UC patients, there are lowere levels of bowel urgency, abdominal pain, and significantly reduced fatigue at eight weeks. There are signs of visible colon lining repair even at one year.

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