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  • US Name:


  • Generic Names:

    Quadmix, Quad-Mix, Quad Mix

  • Active Ingredients:

    Papaverine, Phentolamine, Prostaglandin E1, Atropine

  • Brand Manufacturer:

    Custom Compound

  • Manufacturer Location:


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Prescription Required

Quad-Mix is prescribed to treat erectile dysfunction. It is custom compounded for each order based on the specific instructions from the physician.

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Quad-Mix #4 Generic Compounded
1 mL
Our price: $130.00
Quad-Mix #3 Generic Compounded
1 mL
Our price: $130.00
Quad-Mix #2 Generic Compounded
1 mL
Our price: $130.00

*Please note all prices are in US dollars
Quad-mix is a compounded medication containing papaverine, atropine, phentolamine, and alprostadil (prostaglandin E1) that can be prescribed for men who have erectile dysfunction and for whom other PDE-5 oral medications have failed.  It is injected directly into the penis to promote an erection within 10-15 minutes before intercourse. Compounding medicines is a special practice through which pharmacists can create tailored medications matching the specific needs of the individual patient. Quad-mix combines four chemicals in the precise strengths that meet the specifications of a prescription. Papavarine is a smooth muscle relaxant and vasodilator. Phentolamine causes blood vessels to expand, which increases blood flow. Alprostadil also acts as a smooth muscle relaxant and dilator of blood vessels. Atropine decreases the outflow of blood from the penis, helping to maintain the erection. The four chemicals combine synergistically to create a more effective treatment for erectile dysfunction than each one individually.


Only use Quad-mix as prescribed. Usually, presribing doctors will arrange for the first dose to be administerd under the supervision of a trained healthcare provider, so that any side effects can be monitored and the proper procedure of administration can be demonstrated. The dose should be injected over 5 to 10 seconds into the base of the penis, until it has been completely injected.  This will allow blood to flow into the two hollow chambers (corpus caversnosa) that lie along the length of the shaft of the penis, and facilitate a full erection. Quad-mix must not be injected more than once per day, and not more than two days in a row. The advised maximum use is three times per week, unless this has been approved by a doctor.


Quad-mix can be prescribed in the following combinations of the four components: (Alprostadil/Papverine/Phentolamine/Atropine):
  • Quad-Mix #2: 20mcg/30mg/2mg/100mcg/mL
  • Quad-Mix #3: 30mcg/30mg/3mg/200mcg/mL
  • Quad-Mix #4: 60mcg/30mg/3mg/200mcg/mL.


Store this medication away from the reach of infants and children. The unused doses should be kept in a refrigerator before use, in temperatures between 2°C/37°F and 8°C/48°F sealed from moisture. Allow the dose to reach room temperature before use. Please read our friendly tips on handling medicine safely.


Are penile injections better than PDE-5 meds? Research has shown that injectable therapies such as Quad-mix can trigger an without the need for sexual stimulation and achievement of some hardening. On the other hand oral medications such as PDE-5 drugs like Viagra require sexual stimulation to cause the start of an erection. Quad-mix can also overcome issued of drug absorption that do occur with other oral medications. How long does a penile injection last? After an injection with Quad-mix, the penis can start to swell without physical stimulation. The effect of the combined druds is to cause blood to flow into the hollow chambers of the penis, and to restrict the outflow. The erection can happens within 10 to 15 minutes of the injection and will last up to an hour.

This information is provided for purposes only. It is recommended to seek advice from a healthcare professional before starting any medication.

The majority of individuals using Tri mix components do not typically encounter effects. Physicians prescribe Trimix based on their evaluation that the benefits of treatment outweigh any potential undesired outcomes.

Reported side effects are usually temporary and may include minor bruising or bleeding at the injection site, mild swelling at the point of injection or difficulties with ejaculation. For details on side effects related specifically to alprostadil refer to more information here.

Please note that not all possible side effects are mentioned in this summary. Should you experience persistent or worsening symptoms not listed here it is advisable to seek guidance from a healthcare professional or pharmacist.

Erectile dysfuntions is a common condition in adult males characterized by the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. This can include partial erections that are not firm enough for penetration, erections that are initially firm but fail to sustain rigidity throughout sexual activity or that diminish quickly after penetration or during foreplay.

ED can also have psychological and emotional aspects, including a reduced interest in sexual activities, which can be both a symptom and a contributing factor to ED.

Premature ejaculation may sometimes coexist with erectile dysfunction and complicate the issue, but the two conditions are not the same.

  • Are Quad-mix injections more effective than PDE 5 medications?
    Studies indicate that injectable treatments like Quad mix can induce an erection without the need for direct sexual stimulation and lead to some firmness. In contrast oral drugs such as PDE 5 inhibitors like Viagra require arousal to initiate an erection. Quad mix can also address issues related to drug absorption that may occur with oral medications.
  • What is the duration of a Quad-mix injection's effects?
    Following an injection using Quad-mix the penis may begin to enlarge without physical stimulation. The combination of drugs works by enhancing blood flow into the chambers of the penis while restricting blood outflow. An erection can occur within 10 to 15 minutes post injection. Typically lasts for up to an hour.

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