Low Dose Naltrexone LDN ^*

Low-dose Naltrexone (LDN), usually in strengths of one-tenth or less of the standard dose of naltrexone, has been found to be effective in treating a wide range of conditions. Naltrexone was approved by the FDA in 1984 for prescription in high doses to wean opioid addicts off their dependency. These doses are typically in the range of 50-100 mg a day. Some of the main conditions that Low-dose Naltrexone has been found to be highly beneficial for are:

• Fibromyalgia
• Crohn’s Disease
• Ulcerative Colitis
• Multiple Sclerosis
• Depression

Most research into the treatment of these conditions has found that a daily dosage of around 4.5 mg is adequate. However, depending on the individual patient’s response, it can vary a few milligrams above or below that value. In these conditions and at these levels, naltrexone has been found to exert both analgesic (pain relief) and anti-inflammatory effects. There is also a large body of ongoing research into the possible benefits of LDN in other conditions. Amongst the most promising so far are chronic pain (especially Complex Regional Pain Syndrome), Grave’s Disease (overactive thyroid), inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), many forms of arthritis (including psoriatic arthritis, juvenile arthritis and ankylosing spondylitis), and several female-only conditions such as Polycystic Ovary Syndrome (PCOS), Premenstrual syndrome (PMS) and Dysmenorrhea. Doctors can prescribe LDN in a specific strength, which we can now supply in oral capsules that match this. Until now, there has been no reliable and professional channel by which a required dose can be dispensed to meet the strength that prescribing doctors set to match the specific requirements of their patients. Now, in association with a large laboratory in the US that specializes in compounding medications and that produces a full range of LDN strengths in a convenient format, we can supply the appropriate dose made in a safe and professional environment exactly to match the prescription. For more information about compounding, refer to our guide here.

Dosage

The prescribing doctor sets the dose according to each patient’s condition. Although LDN has not yet been approved in lower doses for any conditions, it is widely prescribed off-label for many.

Storage

Store the capsules in the same container that they were shipped to you, and keep them in a cool, dark space out of the reach of children. Please consult our blog on safe medicine management.

Common Questions about Low Dose Naltrexone

What is naltrexone off-label prescribed for?

Naltrexone in low doses is being more commonly prescribed off-label to manage pain, reduce inflammation, and treat conditions and diseases such as immune dysfunction.

How fast does naltrexone work?

Naltrexone achieves therapeutic effectiveness rapidly. Peak blood concentration is reached within one hour of dosing, and the drug has an elimination half-life of 13 hours.

Why take naltrexone at night?

Most doctors recommend that patients take LDN at bedtime. Naltrexone has been reported to improve sleep patterns in most patients, which leads to improvements in metabolism, insulin resistance, inflammation, and reduced pain levels.