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  • US Name:

    Metformin

  • Alternative Names:

    Glucomin, Glucophage, Metformin, Glumetza

  • Active Ingredients:

    Metformin

  • Brand Manufacturer:

    Merck

  • Manufacturer Location:

    Israel

  • Click here to view Product Insert

  • Click here to view Product Insert

Metformin *

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Glucophage / Metformin / Glumetza is used to help control blood sugar levels in people with type 2 diabetes.

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Glucophage Brand 1000mg
100 Tablets
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Our price:
$60.00
Glumetza Extended Release Brand 1000mg
90 Tablets
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$193.00
Glucomin Generic 850mg
30 Tablets
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$16.00
Metformin Generic 850mg
30 Tablets
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$16.00
Glucophage Brand 500mg
84 Tablets
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$25.20
Metformin Generic 500mg
100 Tablets
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$41.00
Teva-Metformin Generic 500mg
28 Tablets
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$40.00

*Please note all prices are in US dollars
Glucophage / Metformin / Glumetza (generic name: metformin) is an oral medication commonly prescribed to manage type 2 diabetes. It belongs to a class of drugs known as biguanides and plays a key role in controlling blood glucose levels by enhancing insulin sensitivity and reducing glucose production in the liver. By helping patients maintain stable blood sugar levels, Metformin assists in lowering the risk of complications associated with diabetes, such as cardiovascular disease and neuropathy. This medication is often recommended as a first-line treatment for type 2 diabetes, especially in individuals for whom lifestyle adjustments alone do not sufficiently control blood sugar levels. Metformin is considered effective for long-term use due to its established safety profile and its non-reliance on stimulating insulin release, which reduces the likelihood of hypoglycemia (low blood sugar). The Centers for Disease Control and Prevention’s diabetes resources provide more detailed information on living with diabetes, its effects, and diabetes management.

Dosage

It is essential to follow the prescribed regimen closely and avoid dose adjustments unless advised by a qualified healthcare provider. Metformin is available in tablet form and is typically taken one to three times daily with meals to minimize gastrointestinal side effects. The exact dosage varies based on individual blood glucose levels and healthcare provider recommendations. If a dose is missed, take it as soon as possible unless it’s almost time for the next dose; do not double up to make up for a missed dose.

Storage

Metformin tablets should be stored at room temperature, generally between 20-25°C (68-77°F). Keep the medication in its original container, away from moisture, heat, and direct sunlight. Ensure that Metformin is stored out of reach of children and pets to prevent accidental ingestion. For more information, read our article on drug storage.

Common Questions About Metformin

How does Metformin work in the body?
Metformin reduces glucose production in the liver and enhances insulin sensitivity, helping to regulate blood sugar levels without directly stimulating insulin production. This action is beneficial for type 2 diabetes management, as it minimizes the risk of low blood sugar events.
How soon can I expect to see results from Metformin?
Metformin typically begins to improve blood sugar control within a few days of starting, but full benefits may take up to two weeks as the body adjusts. Regular monitoring of blood sugar levels will help track its effectiveness.
Are there non-diabetes conditions that Metformin can treat?
Metformin is sometimes prescribed off-label for polycystic ovary syndrome (PCOS), as it can improve insulin sensitivity and regulate menstrual cycles, though this is not an FDA-approved use.

This text is for informational purposes only. Please consult a doctor or pharmacist before using any medication. 

Read the information leaflet that comes with the medication.

Most people who use Metformin do not experience any adverse side effects. Doctors prescribe this medication because they assess the benefits of such treatment outweigh any likely unwanted effects.

Some of the side effects that have been reported primarily involve gastrointestinal discomfort, including: 

  • Heartburn
  • Stomach pain
  • Nausea or vomiting
  • Bloating
  • Gas.
  • Diarrhea
  • Constipation
  • Weight loss.

These symptoms typically improve as the body adjusts to the medication. However, more serious side effects, such as lactic acidosis—a rare but life-threatening condition—can occur, especially in individuals with compromised kidney function. Symptoms of lactic acidosis include unusual muscle pain, breathing difficulties, and severe tiredness, and require immediate medical attention.

Not all side effects are listed here. If these or other unlisted symptoms persist or worsen, consult a healthcare provider or pharmacist.

Metformin is FDA-approved for the management of type 2 diabetes, assisting in blood glucose control and reducing the risk of complications from high blood sugar levels. Although not commonly approved for type 1 diabetes, it may sometimes be used off-label in combination with insulin in specific type 1 diabetes patients who need additional blood sugar control.

Metformin is also occasionally prescribed off-label to manage polycystic ovary syndrome (PCOS), where it helps regulate menstrual cycles and improve insulin sensitivity.

  • What is metformin mainly used for?
    Metformin is mainly used to treat type 2 diabetes and gestational diabetes. Currently, metformin is the only recommended treatment for people at higher risk of developing diabetes.
  • How does Metformin work?
    Metformin works by increasing insulin sensitivity and decreasing the amount of glucose produced in the liver.
  • What happens if you take metformin without having diabetes?
    The off-label prescription of Metformin for non-diabetics comes from evidence that it can decrease inflammation. It has also been shown to protect against cardiovascular disease, cognitive impairment, to minimize cancer risk and progression, and so to prolong life.
  • How long can you stay on metformin?
    Treatment for type 2 diabetes with metformin is usually for life. If there are signs of kidney damage, doctors may switch to a different medicine. Do not stop taking metformin without talking to a doctor.
  • How quickly will you lose weight on metformin?
    Metformin can cause modest weight reductions when used regularly and for extended periods. In one trial, the average weight loss was between 4-7 pounds for each year of treatment. In another larger trial, it was found that metformin produced a roughly five pounds weight loss over the four-year period.
  • What is metformin used off-label for?
    Metformin also has several non-FDA-approved indications, including gestational diabetes, management of antipsychotic-induced weight gain, and the treatment and prevention of polycystic ovary syndrome (PCOS). Currently, metformin is the only ADA-recommended treatment for pre-diabetics.

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