Manerix (generic name: moclobemide) is a reversible inhibitor of monoamine oxidase A (RIMA) used to treat depression and social phobia. By inhibiting the monoamine oxidase A enzyme, it increases levels of neurotransmitters like serotonin, norepinephrine, and dopamine in the brain, which can improve mood and reduce anxiety. Moclobemide is classified as an antidepressant. Unlike traditional antidepressants that are based on monoamine oxidase inhibitors (MAOIs), moclobemide selectively targets MAO-A and has a reversible binding, leading to fewer dietary restrictions and a more favorable side effect profile. This makes it a valuable option for patients who require antidepressant therapy. MAO-A is responsible for the breakdown of monoamines. Elevated MAO-A activity can lead to excessive serotonin, norepinephrine, and dopamine degradation, resulting in reduced levels of these critical neurotransmitters in the brain. Such depletion has been linked to the core symptoms of depression, including low mood, fatigue, and loss of interest in daily activities.

Dosage

It is essential to follow the prescribing physician’s instructions and not to discontinue the medication abruptly without first consulting with a healthcare professional. Women who are pregnant, trying to become pregnant, or who are breastfeeding should not take Manerix unless this has been approved. If you become pregnant, it is important to refer back to the prescribing doctor as soon as possible. The recommended starting dose for adults is 300 mg daily, divided into two or three doses and taken after meals. The prescribing doctor may adjust the dose depending on the patient’s response and tolerability, but it should not exceed 600 mg daily. If a dose is missed, it should be taken as soon as remembered unless it is less than 3 hours before the next scheduled dose. In such a case, skip the missed dose and continue with the regular dosing schedule. Do not double-dose to make up for the missed one. Manerix is not available in the US but is prescribed elsewhere, such as in the UK, Canada, Australia, and Europe. Doctors can prescribe it off-label when they believe it is the best treatment for this case.

Storage

Store Manerix in its original packaging at room temperature, below 25°C (77°F), in a dry place away from direct light and moisture. Get more advice about safe drug storage.

Common Questions About 

How are RIMAs effective in treating depression?

RIMAs like moclobemide improve mood by increasing neurotransmitters like serotonin, norepinephrine, and dopamine, which are often deficient in individuals with depression. Dopamine is often referred to as the “feel good” hormone.

How does Manerix help with social phobia?

Manerix reduces the anxiety and fear associated with social interactions, helping patients engage more comfortably in social settings.

How long does it take for Manerix to work?

While some patients notice improvements within two weeks, it may take up to four weeks for the medication to achieve its full therapeutic effect.