Lidocaine and prilocaine work by temporarily blocking this pathway of pain signals along nerves. They do this by stopping the sodium entering the nerve ending at the site of the pain. This prevents an electrical signal building up and passing along the nerve fibres to the brain. When Emla cream is applied to the skin, the lidocaine and prilocaine prevent pain signals passing from that area to the brain and so numb the skin. This means otherwise painful procedures can be performed without causing pain.
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