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  • US Name:


  • Generic Names:


  • Active Ingredients:

    Lipase, Protease and Amylase

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Prescription Required

Creon is used to treat deficient pancreatic enzyme secretions.
Creon 10,000 units does not require a Rx.
Creon 25,000 units is a prescription item.

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Creon Brand 25,000 Units
50 Capsules
Our price: $56.00
Creon Brand 10,000 Units
100 Capsules
Our price: $67.00

*Please note all prices are in US dollars
Creon® (lipase, protease, and amylase) is an combined enzyme replacement therapy for patients with deficient exocrine pancreatic secretions, cystic fibrosis, chronic pancreatitis, post-pancreatectomy, ductal obstructions caused by cancer of the pancreas, pancreatic insufficiency and for steatorrhea of malabsorption syndrome and post-gastrectomy (Billroth II and total). Creon in Israel has a slightly different formulation than in the USA.  Below are the details with each enzyme so you can select the right product for you.
USP Units
Lipase Protease Amylase
Creon 12,000 USA 12000 38000 60000
Creon 10,000 Israel 10000 37500 33200
Creon 24,000 USA 24000 76000 120000
Creon 25,000 Israel 25000 62500 74700

Like all medicines, Creon can cause side effects (unwanted effects or reactions). But not everyone gets them. If you have severe or prolonged abdominal pain, contact your doctor immediately. Fibrosing colonopathy : A rare bowel disorder called fibrosing colonopathy was reported in a small number of children, with cystic fibrosis, taking large doses of both high and low-strength enzymes.

Creon is a high strength pancreatic enzyme supplement. Pancreatic enzyme supplements are used by people whose bodies do not make enough of their own enzymes to digest their food. How does it work? The enzymes in Creon work by digesting food as it passes through the gut. It is therefore essential that Creon is taken at the same time as eating a meal or a snack. This will allow the enzymes to mix thoroughly with the food.

Creon is indicated for use in Exocrine Pancreatic Insufficiency (EPI).  EPI is a condition in which your body doesn’t provide enough pancreatic enzymes to properly break down food. People with EPI are unable to properly digest the nutrients in food such as fats, proteins, and carbohydrates, leading to maldigestion.

  • Can I drink alcohol with Creon?
    Alcohol can cause the pancreas to become inflamed and worsen the condition of EPI (exocrine pancreatic insufficiency), which may be due to cystic fibrosis, chronic pancreatitis, surgical removal of the pancreas or other conditions. Because of this, it's best to avoid alcohol if you're taking Creon (pancrelipase). The advice of your healthcare provider should be sought about drinking alcohol.
  • What happens if you don't take Creon with food?
    This medication only works when there's food to digest inside the body. Any scheduled dose of Creon should be skipped if a meal doesn’t follow. The dose cannot be made up, but a regular dose can be taken just before the next meal or snack.
  • Can you lose weight with Creon?
    Creon provides pancreatic enzyme replacement therapy, replacing the enzymes the pancreas would typically produce. For people with pancreatic cancer, cystic fibrosis or whose pancreas has been removed, pancreatic enzyme replacement therapy can help digestion of food. This should actually prevent or reverse weight loss, diarrhea and loss of appetite.
  • Does Creon affect the liver?
    Some side effects coming from the effect of pancreatic enzyme replacement therapy on the liver relating to elevations of liver enzymes have been reported with Creon.
  • What enzymes are in CREON?
    Creon capsules contain the digestive enzymes amylase, lipase and protease, which have been extracted from the pancreas of pigs. All pancreatic enzymes are made from pork products. There is no alternative.

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