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  • US Name:

    Cozaar

  • Israeli Names:

    Losardex, Losartan, Lotan, Ocsaar

  • Active Ingredients:

    Losartan

  • Brand Manufacturer:

    MSD

  • Manufacturer Location:

    The Netherlands

Cozaar

Losartan is used to treat high blood pressure, It is classed as an Angiotensin II antagonist.

Generic Losardex 100mg 30 Tablets $20.00
Generic Losardex 12.5mg 30 Tablets $13.00
Generic Losardex 50mg 30 Tablets $15.00
Generic Lotan 100mg 30 Tablets $13.00
Generic Lotan 12.5mg 30 Tablets $13.00
Generic Lotan 50mg 30 Tablets $13.00
Brand Ocsaar 50mg 30 Tablets $18.00

Losartan is in a group of drugs called angiotensin II receptor antagonists. Losartan keeps blood vessels from narrowing, which lowers blood pressure improves blood flow. Losartan is used to treat high blood pressure (hypertension) and to rCozaar tablets contain the active ingredient losartan potassium, which is a type of medicine called an angiotensin II antagonist. It works by preventing the action of a hormone in the body called angiotensin II. Angiotensin II normally acts on special receptors in the body, with two main results. Firstly, it causes the peripheral blood vessels to narrow, and secondly, it stimulates the production of another hormone called aldosterone. Aldosterone causes salt and water to be retained by the kidneys, which increases the volume of fluid in the blood vessels. Losartan blocks the receptors that angiotensin II acts on, and so prevents its actions. The main result of this is that the peripheral blood vessels are allowed to widen, which means that there is more space and less resistance in these blood vessels. This is the main mechanism by which the pressure in the blood vessels is lowered. Blocking the actions of angiotensin II also reduces the action of aldosterone on the kidneys. The result of this is an increase in the amount of fluid removed from the blood by the kidneys. This decreases the amount of fluid in the blood vessels, which also lessens the resistance and pressure in the blood vessels. The combined overall effect of these changes is to lower the blood pressure, hence losartan is used to treat high blood pressure.

Side effects of Cozaar include:
diarrhea.
stomach pain.
muscle cramps.
leg or back pain.
dizziness.
headache.
sleep problems (insomnia)
tiredness

Hypertension: Ocsaar 50 mg is indicated for the treatment of hypertension
Heart failure: Ocsaar 50 mg is indicated for the treatment of heart failure, usually in addition to
diuretics and/or digitalis, if use of an ACE inhibitor is not appropriate.
Switching patients with heart failure who are stable on an ACE inhibitor to Ocsaar 50 mg is not
recommended.
Renal protection in Type-2 diabetic patients with proteinuria:
Ocsaar 50 mg is indicated to delay the progression of renal disease as measured by a reduction in the
combined incidence of doubling of serum creatinine, end stage renal disease (need for dialysis or renal
transplantation) or death; and to reduce proteinuria.
Reduction in the risk of cardiovascular morbidity and mortality in hypertensive patients with
left ventricular hypertrophy:
Ocsaar 50 mg is indicated to reduce the risk of cardiovascular morbidity and mortality as measured by
the combined incidence of cardiovascular death, stroke, and myocardial infarction in hypertensive
patients with left ventricular hypertrophy.
The benefit of Ocsaar 50 mg on the primary deposite endpoint was largely driven by reduction in the
risk of stroke.

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