Buscopan ^*

Buscopan (generic name:  butylbromide) is an antispasmodic medication primarily used to relieve abdominal pain and discomfort associated with cramps and spasms in the gastrointestinal tract. It is effective in treating conditions such as irritable bowel syndrome (IBS) and other functional bowel disorders characterized by smooth muscle spasms. By relaxing the smooth muscles of the stomach, intestines, and other parts of the digestive system, Buscopan helps alleviate pain and discomfort resulting from involuntary muscle contractions.​

Butylbromide, the active ingredient in Buscopan, is a muscarinic receptor antagonist. It works by competitively inhibiting the action of acetylcholine, a neurotransmitter responsible for stimulating muscle contractions in the gastrointestinal tract. This inhibition leads to relaxation of the smooth muscles, thereby reducing spasms and associated pain during abdominal cramping. ​

Unlike some anticholinergic agents, butylbromide is a quaternary ammonium compound, which means it carries a positive charge. This characteristic limits its ability to cross the blood-brain barrier, resulting in minimal central nervous system effects. Consequently, Buscopan primarily exerts its effects peripherally, targeting the smooth muscles of the gastrointestinal tract without significant impact on the brain.

Buscopan belongs to the anticholinergic class of medications, also known as parasympatholytics. Drugs in this class inhibit the actions of the parasympathetic nervous system by blocking the binding of acetylcholine to its receptors. After oral administration, peak plasma concentrations are typically reached within two hours. Due to its limited penetration of the central nervous system, Buscopan has a favorable safety profile with a lower incidence of central anticholinergic side effects such as confusion or sedation. However, peripheral anticholinergic effects may still occur, including dry mouth, tachycardia, and urinary retention.

Caution: Patients with conditions such as glaucoma, myasthenia gravis, or megacolon should use Buscopan with caution, as anticholinergic agents can exacerbate these conditions.

Dosage

The dosage of Buscopan varies based on age and the condition being treated:

• Adults and children over 12: The standard dose is two 10 mg tablets taken four times daily. For IBS symptoms, a starting dose of one 10 mg tablet three times daily is recommended, which can be increased to two tablets four times daily if necessary.

• Children aged 6 to 12: The typical dose is one 10 mg tablet taken three times daily.

Buscopan tablets should be swallowed whole with water and not crushed or chewed. If a dose is missed, it should be taken as soon as remembered unless it is nearly time for the next dose. Do not double-dose to make up for a missed dose.

Storage

Buscopan should be stored at room temperature, ideally below 25°C (76°F), in its original packaging to protect it from moisture. It should not be stored in damp areas like bathrooms to maintain its effectiveness and safety.

Common Questions About Buscopan

How quickly does Buscopan work?

Buscopan typically starts to work within 15 minutes of ingestion, providing rapid relief from painful cramps.

Are there any dietary restrictions while taking butylbromide?

There are no specific dietary restrictions associated with hyoscine butylbromide; however, maintaining a balanced diet may help manage the underlying conditions being treated.

Can Buscopan be used for bladder spasms?

Yes, Buscopan can be used to relieve bladder spasms by relaxing the smooth muscles of the urinary tract.