If you’re coping with irritable bowel disease (IBD) and treatments aren’t working, chances are you’ve looked into other options that might not be available locally. If you’ve stumbled on domperidone, better known as Motilium, you’ve probably got some questions, especially if you live in the U.S.
Domperidone is known as a dopamine antagonist, which is an anti-sickness medicine that can be used not only for IBD, but also for other feelings of reflux, bloating, and fullness. It works by blocking dopamine receptors found in the upper part of the digestive system and relaxes the muscles at the exit of the stomach, which speeds up the passage of food through the stomach and into the intestines. Even more, it prevents food from flowing the wrong way through the stomach aiding problems with reflux.
Also, domperidone works to block dopamine receptors in the brain in the chemoreceptor trigger zone (CTZ), which are activated when an irritant is present in the stomach (nerve messages are shipped from the stomach to the CTZ). In this case, domperidone helps to block these sensors, which reduces the sensation of nausea and prevents vomiting.
With all of these powerful aids in mind, Motilium not only works with IBD, but can also be used to prevent nausea and vomiting that is often caused by medicines used to treat Parkinson’s disease. It’s also effective in treating the nausea and vomiting associated with anti-cancer chemotherapy, drugs used to treat migraines, and the side effects of emergency hormonal contraceptives (the morning-after pill or Plan B).
So why can’t you find it in the U.S.? In 2004 the FDA released a warning for physicians and pharmacists not to dispense domperidone, and since then it’s been next to impossible to locate for U.S. citizens and it is becoming harder for European citizens, too. However, according to the National Association of Boards of Pharmacy,
Although domperidone is not FDA approved, FDA recognizes there are some patients with severe gastrointestinal motility disorders that are refractory to standard therapy who may benefit from the use of domperidone and in whom the benefits of the drug may outweigh its risks.
As a result, many doctors will prescribe Motilium, but finding a pharmacy to dispense the drug is next to impossible, which is where reliable, secure pharmacies like IsraelPharm come into play. With a prescription from your physician, you can buy domperidone online without any trouble.
Have questions about whether domperidone is right for you? We encourage you to talk to your doctor and if you’re curious about dosing, please speak with our pharmacist Saul.