GLP-1 drugs like Ozempic and Mounjaro are everywhere – on TV, online, and even in celebrity interviews. But what this chatter about losing weight rarely explains are the real-world challenges: side effects, access, cost, and what happens when people stop taking them. Here’s what people need to know before getting swept up in the hype.
A brief history of Ozempic and the surprise discovery of weight loss
Originally approved to treat type 2 diabetes, Ozempic (semaglutide) was designed to help control blood sugar by mimicking the hormone GLP-1 agonists (glucagon-like peptide-1). GLP-1 slows stomach emptying and increases feelings of fullness, which turned out to have a powerful side effect: it helped people lose weight. That wasn’t the original goal, but it became a major breakthrough. Studies soon showed that semaglutide helped with appetite suppression and led to unexpected and sustained weight loss, even in people without diabetes. That’s when demand exploded, leading to new versions aimed specifically at weight loss.
Off-label use of diabetes drugs for losing weight before approval
Before Wegovy (weight loss version of Ozempic) was formally approved for treating obesity, many doctors were already prescribing Ozempic off-label for people who wanted to lose weight. This means the drug was used outside its official FDA-approved purpose. While off-label use is legal and often supported by science, it isn’t often covered by insurance. That made the weight-loss use of these drugs a luxury few could afford, and supply was stretched thin even for people with diabetes who needed it for their condition.
Mounjaro was a new drug that offered stronger effects, but at a cost
Mounjaro (tirzepatide) is another GLP-1-related drug that’s technically a dual agonist, meaning it works on both GLP-1 and a second hormone receptor called GIP. This combination showed even better results for weight loss in clinical studies. Just like Ozempic, Mounjaro was first approved for diabetes, but doctors began prescribing it off-label for weight loss. Then came Zepbound – Eli Lilly’s FDA-approved tirzepatide version for obesity. It works, no doubt. But again, the price tag is high, and insurance often refuses to cover it unless certain health conditions are met.
Wegovy and Zepbound mark a shift to official weight-loss treatments
The arrival of Wegovy and Zepbound brought a new era of prescription treatments for obesity. They contain the same ingredients as Ozempic and Mounjaro but are approved specifically for weight loss. This means clearer guidelines, more marketing, and more demand. However, shortages remain common, and many people are still unable to access them easily. Their use is limited by cost, supply, and insurance rules, leaving patients searching for alternatives.
Group studies show real, sustained weight loss in many users
Large-scale studies show that people who stick with these GLP-1 drugs can lose up to 15–20% of their body weight over a year. These results are especially promising for people with obesity or weight-related health issues. However, it’s not a miracle fix. People often regain weight if they stop taking the drug. Ongoing use is usually necessary to maintain results, which raises questions about long-term affordability and sustainability.
Compounded semaglutide and tirzepatide: Cheaper, but risky
Because of the high cost and shortages, some patients have turned to compounded versions of semaglutide and tirzepatide. These are made by specialty pharmacies and can cost far less than branded drugs. But there’s a catch. Compounding isn’t regulated the same way as brand-name drugs. Quality varies, and there are risks if the pharmacy isn’t reputable. The FDA has warned consumers to be cautious. IsraelPharm sources its compounded semaglutide or tirzepatide only from U.S.-licensed compounding pharmacies that can be trusted.
Widespread side effects, including Ozempic face and weight loss rebound
Not everyone has an easy time on these drugs. Common side effects include nausea, constipation, and fatigue. Others experience more noticeable changes, like what some call “Ozempic face” – a sunken look caused by rapid weight loss. There’s also the issue of rebound weight gain. Once people stop the drug, many regain the lost weight, and sometimes more. That’s because the underlying causes of weight gain, like poor diet, stress, or genetics, haven’t been addressed.
Hidden obstacles you don’t often hear about
There are multiple reasons people struggle to get or stay on these medications:
- High cost: Monthly costs can exceed $1000 without insurance.
- Insurance barriers: Most plans only cover the drugs for diabetes, not weight loss.
- Supply shortages: Demand often outpaces supply, especially during media hype.
- Long-term usage: These drugs often need to be taken long term, adding to costs.
For many people, the promise of weight loss collides with the reality of financial or logistical limits.
Looking for better options: Alternative supply chains and healthy supplements
While GLP-1 drugs are effective, they aren’t the only way to manage weight. Slow and steady approaches still matter. Lifestyle changes and affordable support tools like the Healthy Weight Pack can help maintain results or act as a starting point. And for those who need prescription medication for weight loss, IsraelPharm can provide more reliable and more affordable access via courier shipping and international sourcing, even during U.S. shortages.
Frequently asked questions about ads about weight loss
Why are GLP-1 drug ads everywhere right now?
These drugs have been shown to cause rapid weight loss, which makes them very popular. Ads tap into public interest and target people looking for fast results. Now that Wegovy and Zepbound are FDA-approved specifically for weight loss, they can be marketed directly to consumers. However, the ads often leave out important details like cost, side effects, or the need for long-term use.
Is it safe to take these drugs just to lose weight?
Many people take GLP-1 diabetes meds off-label for weight loss. While studies support their safety, especially for people with obesity, they were originally developed to control blood sugar levels. Using them solely for weight loss should be discussed with a doctor, especially due to side effects and long-term effects that aren’t fully understood yet.
What is “Ozempic face” and is it dangerous?
“Ozempic face” is a slang term for facial aging or hollowed cheeks that sometimes happen after rapid weight loss. It’s not harmful, but it can change appearance in ways some people find unsettling. This side effect tends to happen more in older adults or those who lose weight very quickly.
Can weight come back after stopping the medication?
Yes. Many people regain the weight they lost if they stop taking GLP-1 drugs. That’s because these medications help control appetite and cravings, and without them, old eating patterns often return. Long-term weight loss usually requires continued use of the medication or major lifestyle changes.
Are there more affordable ways to lose weight using GLP-1 drugs?
Some compounding pharmacies offer cheaper versions of semaglutide and tirzepatide, but safety can be an issue, so sourcing them from a reliable supplier like IsraelPharm is important. Buying regular weight-loss meds through trusted international pharmacies like IsraelPharm can significantly reduce costs. Supplements like the Healthy Weight Pack can also offer gentle support for appetite control without the same costs or risks.
