Zestril/Lisinopril (generic name: lisinopril) is an ACE inhibitor (angiotensin-converting enzyme inhibitor) used primarily for the treatment of high blood pressure (hypertension) in patients aged 6 years and older. Zestril is also commonly prescribed to treat systolic heart failure, helping to alleviate symptoms like shortness of breath and fatigue, which improves the patient’s quality of life and overall cardiac function. Additionally, Zestril has a significant role in managing patients after an acute myocardial infarction (heart attack), as it reduces mortality rates by enhancing blood flow and minimizing heart muscle stress post-infarction. By inhibiting the enzyme responsible for converting angiotensin I to angiotensin II, Zestril promotes the dilation of blood vessels, which helps lower blood pressure and reduces the workload on the heart. This mechanism is crucial for preventing complications associated with high blood pressure, such as stroke, heart attack, and kidney damage.

Caution

Zestril can cause injury to a developing fetus in the second and third trimesters of pregnancy. Consult with a doctor immediately if pregnancy is detected, since medication with Zestril must be stopped immediately.

Dosage

Typical dosing for Zestril varies based on the condition being treated. For hypertension in adults, the initial dose is usually 10 mg once daily, with a maintenance range of 20-40 mg per day. Children 6 years and older may start at a lower dose based on body weight. For heart failure, the usual starting dose is 5 mg once daily, with potential adjustments. Post-myocardial infarction, the recommended starting dose is 5 mg, followed by 10 mg once daily for at least six weeks.

Storage

Zestril should be stored in its original packaging at room temperature (20-25°C/68-77°F) in a dry place, protected from moisture and light. For more help, read our article on drug storage.

Common Questions About Zestril

How does Zestril work to lower blood pressure?

Zestril works by inhibiting an enzyme that produces angiotensin II, which causes blood vessels to constrict. This action relaxes the blood vessels, reducing blood pressure and making it easier for the heart to pump blood.

How should lisinopril be taken for best results?

Lisinopril should be taken exactly as prescribed, typically once daily, with or without food. It’s advised to take it at the same time each day to maintain consistent blood pressure control.

What should I avoid while taking Zestril?

Doctors advise most patients to avoid potassium supplements or salt substitutes containing potassium, as these can increase the risk of hyperkalemia. Alcohol consumption should also be minimized as it can enhance the blood pressure-lowering effect and cause dizziness.