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  • US Name:

    Zemplar

  • Alternative Names:

    Zemplar

  • Active Ingredients:

    Paricalcitol

  • Brand Manufacturer:

    Abbvie

  • Manufacturer Location:

    UK

  • Click here to view Product Insert

  • Click here to view Product Insert

Zemplar

Prescription Required

Zemplar is a drug prescribed to lower parathyroid hormone levels associated with chronic renal disease.

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Zemplar Brand 1mcg
28 Capsules
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Our price: $153.00

*Please note all prices are in US dollars
Zemplar (generic name: paricalcitol) is a synthetic analog of Vitamin D. It is prescribed to patients with chronic kidney disease and stage four or stage five dialysis patients to prevent and treat secondary hyperparathyroidism (elevated parathyroid hormone levels) in adults and children 10 years of age and older. When kidney function deteriorates, it might result in a condition known as secondary hyperparathyroidism (SHPT). Secondary hyperparathyroidism is quite frequent in persons with chronic kidney disease (CKD) in stages four and five. It can potentially cause the parathyroid glands to chronically swell. Zemplar works by directing the parathyroid glands to stop producing excessive parathyroid hormone.

Dosage

The dosage is determined by the prescribing doctor. Zemplar is typically prescribed to be taken as a daily dose at first, and then a maximum of three times per week, and only on alternate days. Follow all instructions on the medicine label and read any drug guidelines or instruction sheets. The capsules should not be chewed or crushed, but only swallowed whole with a small amount of liquid. It can be taken with or without food.

Caution

If by accident a higher dose that normal has been taken or a child has swallowed one or more capsules, there can be a serious outcome due to the abnormal increase in blood calcium levels. Consult a doctor immediately, or call 911 for help or go directly to a hospital emergency room, talking the box of capsules with.

Storage

Keep Zemplar oral capsules at room temperature, away from moisture, light, and heat. Read our tips on handling medicine safely for a guide on safe storage and disposal.

This text is for informational purposes only. Please consult a doctor or pharmacist before using any medication. 

Read the information leaflet that comes with the medication.

Most people who use Zemplar do not experience any negative side effects. Doctors prescribe Zemplar because they assess that the benefits that such treatment yields outweigh any likely unwanted effects.

If after taking Zemplar a person experiences a sudden allergic reaction (anaphylaxis), with symptoms like swelling of the face, tongue or throat making it difficult to breathe or swallow, or there is wheezing, hives, rash, blistering or peeling of the skin, call a doctor or 911 right away, or go to an emergency room immediately.

Some of the side effects that have been reported include:

  • Gastrointestinal bleeding
  • Chills
  • Nausea
  • Vomiting
  • Fever
  • Influenza
  • Pneumonia
  • Sepsis
  • Dry mouth
  • Edema

 

Serious side effects are:

  • Confusion
  • Slurred speech
  • Arm or leg weakness
  • Loss of coordination
  • Tremors.
  • Sudden loss of vision
  • Eye pain or swelling
  • Fast, irregular, or hammering heartbeats
  • Fluttering in the chest
  • Shortness of breath

Zemplar is indicated in the treatment and prevention of high levels of parathyroid hormone, a natural substance produced by the body in patients with long-term renal impairment. 

A lack of calcium and a specific type of vitamin D can cause an excess of parathyroid hormone. If not treated properly, it can lead to high blood calcium levels (hypercalcaemia), which may cause symptoms like:

  • Nausea and vomiting
  • Drowsiness and confusion
  • Dehydration
  • Muscle spasms.
  • Bone pain
  • Joint tenderness or pain
  • Irregular heartbeats.

It might also lead to significant bone abnormalities and osteoporosis.

  • What happens if I miss a dose of Zemplar?
    Take the medication as soon as possible, but skip the missed dose if it is almost time for the next dose. Do not take two doses at the same time.
  • What should I avoid when using Zemplar?
    Avoid using vitamin D or calcium supplements without consulting a doctor. Before using an antacid or other mineral supplements, consult the doctor and stick to the one he or she advises.
  • Are there drugs that affect Zemplar?
    Zemplar can be affected by drugs such as cholestyramine and mineral oil. For these medications, the oral Zemplar dose should be taken one hour before or four to six hours after the other treatment. Other drugs that interact with Zemplar are digoxin (digitalis), a diuretic or "water pill", nefazodone, a phosphate binder (ferric citrate), antibiotic, antifungal, and antiviral drug

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