Xcopri (generic name: cenobamate) is an anticonvulsant medication used to treat partial-onset seizures in adults. Partial-onset seizures, also known as focal seizures, originate in one area of the brain and can impact motor control, sensory perception, and awareness. Cenobamate works by modulating the activity of voltage-gated sodium channels and enhancing GABAergic inhibitory currents, which helps to stabilize neuronal firing and prevent seizure propagation. This dual-action mechanism provides broad-spectrum anti-seizure activity that can be effective even when other treatments have not fully controlled seizure episodes. Xcopri is prescribed for patients whose partial-onset seizures have not been adequately managed by previous medications. The drug’s efficacy in reducing seizure frequency was demonstrated in clinical trials, showing significant improvement for many patients.

Dosage

It is essential for patients to start taking Xcopri under medical supervision, as the titration schedule must be carefully managed to reduce the risk of side effects. As well, patients are advised not to abruptly stop taking Xcopri without medical guidance, as this could increase the risk of seizure recurrence. A healthcare professional should oversee gradual withdrawal or adjustments. The dosing for Xcopri starts with a low initial dose that gradually increases over several weeks. Typically, treatment begins at 12.5 mg daily for the first two weeks. The dose is then escalated to 25 mg daily for the next two weeks, followed by increases to 50 mg daily and then 100 mg daily at biweekly intervals. The maximum recommended maintenance dose is generally 200 mg per day, but it can be increased to 400 mg per day based on clinical response and tolerability.

Storage

Store Xcopri in its original containers at room temperature, between 20-25°C (68-77°F), and keep it in a dry place, away from light and moisture. For more information, read our article on drug storage.

Common Questions About Xcopri

What is Xcopri used for?

Xcopri is used to manage partial-onset seizures in adults with epilepsy. It is typically prescribed when other medications have not achieved sufficient seizure control. Xcopri works by stabilizing brain activity, which can help reduce the frequency and severity of seizures.

How should Xcopri be taken?

Xcopri is taken orally, typically once daily, following a titration schedule. Patients start with a low dose, which gradually increases as prescribed. This titration helps the body adjust to the medication while minimizing side effects. Patients should take Xcopri at the same time each day, with or without food, and avoid doubling doses if they miss one.

Can cenobamate cause allergic reactions?

Yes, cenobamate can cause allergic reactions in rare cases, including serious skin reactions like Stevens-Johnson syndrome. Symptoms to watch for include rash, swelling, and breathing difficulties. Patients experiencing any of these should seek medical assistance immediately. It’s essential to inform healthcare providers about any past allergic reactions to medications before starting cenobamate to reduce potential risks.