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Vraylar is used to treat major depressive disorder (MDD), bipolar I disorder (manic bouts and depressive episodes), and schizophrenia.

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Vraylar (generic name: cariprazine) is typically prescribed along with antidepressant medicines to treat major depressive disorder (MDD). It is used to treat short-term bouts of acute mania or mixed episodes that happen with bipolar I disorder, as well as to treat depressive episodes that can occur with bipolar I (bipolar depression). It can be prescribed for people diagnosed with schizophrenia. Cariprazine treats symptoms but does not cure these conditions. Cariprazine must be taken while the patient is under the supervision of a trusted healthcare provider. Benefits may only be felt after several weeks, but one should not stop taking the drug without talking to their prescribing physician. Cariprazine should be taken in the prescribed dose even if symptoms go away. Talk to a doctor if you do not feel an improvement during treatment with cariprazine.


Cariprazine capsules can be taken with or without food. It is best to take cariprazine at around the same time every day. If a dose is missed and can be made up on the same day, it can be taken. Otherwise, the missed dose should not be made up for the next day. Do not double-dose.

Read the manufacturer’s Product Insert leaflet that comes with the medication before using it. Remember that not all possible side effects can be listed here. If you experience any of these or any other unexpected side effects, seek medical attention from your prescribing physician.

Cariprazine may cause some of the following less serious side effects:

  • Extreme tiredness; difficulty falling asleep or staying asleep
  • Restlessness; anxiety; agitation
  • Dizziness; feeling unsteady; having trouble keeping your balance
  • Increased appetite; weight gain; constipation; indigestion or nausea
  • Increased saliva; drooling
  • Blurred vision.

If these symptoms persist or worsen, report them to a doctor or pharmacist.

Some side effects can be severe. If you experience any symptoms of an allergic reaction, such as a rash, itching, hives, or swelling of the face, throat, tongue, lips, or eyes, go immediately to an emergency healthcare facility and tell them you are taking Cariprazine. 

Other symptoms that should be reported to a doctor immediately are seizures, fever, sweating, confusion, fast breathing, fast or irregular heartbeat, or suicidal thoughts.

Vraylar is a dopamine and serotonin partial agonist that has been approved for the treatment of schizophrenia. It is also prescribed for the treatment of depressive episodes associated with bipolar I disorder (manic or mixed episodes in adults.)

Vraylar is also approved as an add-on treatment for major depressive disorder (MDD), along with antidepressant adjuncts and atypical antipsychotics.

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