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Viibryd is a serotonin partial agonist–reuptake inhibitor (SPARI) drug prescribed for the treatment of major depressive disorder (MDD) in adults.

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Viibryd (vilazodone) is an oral anti-depression medicine prescribed for the treatment of major depressive disorder (MDD) in adults. Vilazodone is a serotonin partial agonist–reuptake inhibitor (SPARI), which combines a selective serotonin reuptake inhibitor (SSRIs) with a serotonergic receptor partial agonist. It works by increasing the amount of the neurotransmitter called serotonin, a natural substance in the brain that helps maintain mental balance.


Take Viibryd exactly as directed by the prescribing doctor. It is usually taken with food once each day. Try to take the dose at the same time every day. Doctors typically start treatment with a low dose of vilazodone and gradually increase it. Do not take more or less than the doctor prescribes, even if the symptoms improve.

This text is for informational purposes only. Please consult a doctor or pharmacist before using any medication. 

Read the information leaflet that comes with the medication.

Most people who use Viibryd do not experience any negative side effects. Doctors prescribe Viibryd because they assess that the benefits of such treatment outweigh any likely unwanted effects.

Some of the side effects that have been reported include:

  • Gastrointestinal disorders such as diarrhea, nausea, dry mouth, vomiting, abdominal pain, dyspepsia, flatulence, gastroenteritis, abdominal distension
  • Nervous system disorders such as headaches, dizziness, somnolence (sleepiness), tingling and pins-and-needles

Not all side effects are listed here. If these or other unlisted symptoms persist or worsen, consult a healthcare provider or pharmacist.

Serotonin is a neurotransmitter in the brain that regulates mood. It is sometimes called the natural “feel good” chemical. When serotonin is at normal levels, a person will feel more focused, stable, happier and calmer. Low levels of serotonin are associated with depression.

Major Depressive Disorder (MDD) is diagnosed when an individual has at least five of the following symptoms for at least two weeks:

  • A persistently low or depressed mood
  • Feelings of guilt or worthlessness
  • Lack of energy
  • Poor concentration
  • Impaired cognitive function
  • Loss of interest in things and activities that used to bring pleasure
  • Appetite changes which may cause weight gain or weight loss
  • Psychomotor agitation (slowed speech or decreased movement)
  • Sleep disturbances
  • Suicidal thoughts
  • What type of antidepressant is Viibryd?
    Vilazodone belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). They work by increasing the activity of a neurotransmitter called serotonin in the brain.
  • Is vilazodone addictive?
    Vilazodone is less likely to cause abuse and addiction than other antidepressants. There have been no reports of drug abuse and addiction with Viibryd, but people can develop physical tolerance and dependence, which makes it more difficult to keep to lower dosages of drug.
  • When does vilazodone kick in?
    Within the first 1–2 weeks of starting treatment, people can start to notice improvements in sleep, energy, and appetite. These are an early signal that the medication is working. It can take up to two months before the depressed mood and lack of interest in activities fully improve.
  • What makes Viibryd unique?
    Vilazodone combines two mechanisms in one drug. It is an SSRI combined with serotonin-receptor partial agonist - a serotonin partial agonist reuptake inhibitor (SPARI).
  • Can vilazodone cause weight gain?
    Very few patients in clinical studies saw an increase in their weight. Weight gain may still occur in patients who suddenly stop taking the drug.
  • Can I drink alcohol while taking vilazodone?
    The use of alcohol when taking this medicine in not advisable. Viibryd may cause a person to feel dizzy or sleepy, and alcohol can make this worse. Don't drive or use heavy machinery until these side effects have abated..

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