How long before Uptravi works?

Individual response varies. Clinical data show benefits, such as slowed disease progression and improved exercise tolerance, over the course of several months following dose adjustments.

What dose adjustments are needed with liver problems?

No change is needed for mild hepatic impairment (Child-Pugh A). In moderate impairment (B), doctors usually reduce to once-daily dosing.

What Is pulmonary hypertension?

PAH causes high blood pressure in the arteries of the lungs. The main symptoms are shortness of breath, especially when exercizing, fatigue, coughing, chest pain, and general weakness.

How well does Uptravi improve exercise capacity?

In trials, Uptravi increased six-minute walk distance by an average of ~12 meters compared to placebo, indicating measurable clinical benefit.

Is Uptravi used with other PAH medications?

Yes. It is often added when treatment with endothelin receptor antagonists or PDE5 inhibitors is insufficient. It may also be used as monotherapy.

Does Uptravi cure PAH?

No. It slows progression, lowers hospitalization risk, and improves symptoms, but ongoing therapy and monitoring are necessary. There is currenty no cure for pulmonary hypertension.

Must a patient on Uptravi be monitored?

Yes. Patients need periodic blood pressure, CBC, liver function tests, and hemoglobin measurements during drug level adjustments and maintenance. Awareness of side effects like hypotension or anemia is also essential.

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Home / Online Pharmacy / Uptravi

For visual reference only; actual product may vary

US Name:

Uptravi
Alternative Names:

Uptravi
Active Ingredients:

Selexipag
Brand Manufacturer:

Johnson & Johnson
Manufacturer Location:
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Uptravi ^*

For visual reference only; actual product may vary

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All third-party products, company names, and logos are trademarks™ or registered® trademarks are and remain the property of their respective holders. Their use does not imply any affiliation with or endorsement by them. All references on this site to third-party trademarks are intended to constitute nominative fair use under applicable trademark laws.

Uptravi is prescribed for the treatment of pulmonary arterial hypertension (PAH, WHO Group I).

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Uptravi Brand	1600mcg 60 Tablets	- Uptravi – Brand, Uptravi, 1600mcg, 60, Tablets, 22883, Johnson and Johnson, 2678 + 0	Our price: $3,800.00
Uptravi Brand	1400mcg 60 Tablets	- Uptravi – Brand, Uptravi, 1400mcg, 60, Tablets, 22882, Johnson and Johnson, 2677 + 0	Our price: $3,800.00
Uptravi Brand	1200mcg 60 Tablets	- Uptravi – Brand, Uptravi, 1200mcg, 60, Tablets, 22780, Johnson and Johnson, 2676 + 0	Our price: $3,800.00
Uptravi Brand	1000mcg 60 Tablets	- Uptravi – Brand, Uptravi, 1000mcg, 60, Tablets, 22743, Johnson and Johnson, 2675 + 0	Our price: $3,800.00
Uptravi Brand	800mcg 60 Tablets	- Uptravi – Brand, Uptravi, 800mcg, 60, Tablets, 22561, Johnson and Johnson, 2674 + 0	Our price: $3,800.00
Uptravi Brand	600mcg 60 Tablets	- Uptravi – Brand, Uptravi, 600mcg, 60, Tablets, 22559, Johnson and Johnson, 2673 + 0	Our price: $3,800.00
Uptravi Brand	400mcg 60 Tablets	- Uptravi – Brand, Uptravi, 400mcg, 60, Tablets, 22558, Johnson and Johnson, 2672 + 0	Our price: $3,800.00
Uptravi Brand	200mcg 60 Tablets	- Uptravi – Brand, Uptravi, 200mcg, 60, Tablets, 22481, Johnson and Johnson, 2671 + 0	Our price: $3,700.00

*Please note all prices are in US dollars

Description
Side Effects
Indications
FAQ
Video

Uptravi (generic name: selexipag) is prescribed for the treatment of pulmonary arterial hypertension (PAH, WHO Group I), a condition characterized by high pulmonary artery pressure that strains the heart and lungs.

Selexipag is a prostacyclin receptor agonist that will selectively stimulate the prostacyclin IP receptor on vascular smooth muscle cells, promoting vasodilation, inhibiting vascular remodeling, and reducing platelet aggregation. This helps to slow disease progression and reduce the risk of hospitalization,

Dosage

Follow the instructions on the label of the Uptravi box. If you have any questions, consult with a doctor or pharmacist.

The typical oral dosing regimen begins at 200 mcg twice daily, with food, approximately 12 hours apart. Typically, the dose is gradually increased weekly in 200 mcg increments until the highest tolerated dose is reached, up to a maximum of 1600 mcg twice daily.

If a patient misses a dose and the next scheduled dose is more than 6 hours away, take it as soon as remembered. If less than 6 hours remain, skip the missed dose and continue with your normal schedule. Don’t stop taking the medicine without consulting a doctor. In the event of an accidental overdose, call 911 or go to an emergency medical care center immediately.

Storage

Tablets should be stored at 20–25 °C (68–77 °F) in original packaging, protected from moisture and out of children’s reach. If in any doubt, consult our blog on safe medicine management.

This text is for informational purposes only. Please consult a doctor or pharmacist before using any medication.

Read the information leaflet that comes with the medication.

If a sudden allergic reaction (anaphylaxis) occurs shortly after taking Uptravi, with symptoms like swelling of the face, tongue, or throat making it difficult to breathe or swallow, or there is wheezing, hives, rash, blistering, or peeling of the skin, call a doctor or 911 right away, or go to an emergency room immediately.

Most people who use Uptravi do not experience any adverse side effects. Doctors prescribe this medication because they assess the benefits of such treatment outweigh any likely unwanted effects.

Some of the side effects that have been reported include:

headache
diarrhea
jaw pain
nausea and vomiting
myalgia
pain in arms or legs
flushing
joint pain
anemia
rash
decreased appetite
upper respiratory symptoms.

Not all side effects are listed here. If these or other unlisted symptoms persist or worsen, consult a healthcare provider or pharmacist.

Uptravi is approved for adult patients with pulmonary arterial hypertension (PAH, WHO Group I), a chronic condition marked by constriction and remodeling of pulmonary arteries, leading to elevated blood pressure within these vessels.

PAH symptoms include shortness of breath, fatigue, dizziness, chest pain, swelling of ankles or legs, and reduced ability to perform exercise due to impaired blood flow to the lungs and heart.

How long before Uptravi works?

Individual response varies. Clinical data show benefits, such as slowed disease progression and improved exercise tolerance, over the course of several months following dose adjustments.
What dose adjustments are needed with liver problems?

No change is needed for mild hepatic impairment (Child-Pugh A). In moderate impairment (B), doctors usually reduce to once-daily dosing.
What Is pulmonary hypertension?

PAH causes high blood pressure in the arteries of the lungs. The main symptoms are shortness of breath, especially when exercizing, fatigue, coughing, chest pain, and general weakness.
How well does Uptravi improve exercise capacity?

In trials, Uptravi increased six-minute walk distance by an average of ~12 meters compared to placebo, indicating measurable clinical benefit.
Is Uptravi used with other PAH medications?

Yes. It is often added when treatment with endothelin receptor antagonists or PDE5 inhibitors is insufficient. It may also be used as monotherapy.
Does Uptravi cure PAH?

No. It slows progression, lowers hospitalization risk, and improves symptoms, but ongoing therapy and monitoring are necessary. There is currenty no cure for pulmonary hypertension.
Must a patient on Uptravi be monitored?

Yes. Patients need periodic blood pressure, CBC, liver function tests, and hemoglobin measurements during drug level adjustments and maintenance. Awareness of side effects like hypotension or anemia is also essential.

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All orders for prescription medication on this site require a valid prescription. The information found on this site is for informational purposes only. Please consult your doctor or pharmacist before purchasing any medication. Please review the instructions included with the medication before starting your treatment. You can contact us with any questions regarding usage, side effects, or drug interactions at any time.
All third-party products, company names, and logos are trademarks™ or registered® trademarks are and remain the property of their respective holders. Their use does not imply any affiliation with or endorsement by them. All references on this site to third-party trademarks are intended to constitute nominative fair use under applicable trademark laws.

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