Side effects include mild to moderate nausea within the first two weeks of treatment. Gastrointestinal adverse reactions, such as nausea, occurred more frequently in women than men. Class effect Epidemiological studies, mainly conducted in patients 50 years of age and older, show an increased risk of bone fractures in patients receiving a medicinal product from related pharmacological classes of antidepressants (SSRIs or TCAs). The mechanism behind this risk is unknown, and it is not known if this risk is also relevant for vortioxetine.
Trintellix is indicated for the treatment of major depressive episodes in adults.