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  • US Name:


  • Israeli Names:

    Brintellix, Fonksera

  • Active Ingredients:


  • Brand Manufacturer:


  • Manufacturer Location:



Brintellix, Trintellix, and Fonksera are all the same medication (vortioxetine) manufactured by Lundbeck.

Brintellix is indicated for the treatment of major depressive episodes in adults.

28 Tablets
28 Tablets
28 Tablets
28 Tablets
*Please note all prices are in US dollars

Vortioxetine was previously trademarked as Brintellix in the United States, but the US FDA approved a name change to Trintellix in 2016. In Europe, Lundbeck has changed the name of Brintellix to Fonksera. The brand Vortioxetine can be called Brintellix, Trintellix, and Fonksera.


Side effects include mild to moderate nausea within the first two weeks of treatment. Gastrointestinal adverse reactions, such as nausea, occurred more frequently in women than men. Class effect Epidemiological studies, mainly conducted in patients 50 years of age and older, show an increased risk of bone fractures in patients receiving a medicinal product from related pharmacological classes of antidepressants (SSRIs or TCAs). The mechanism behind this risk is unknown, and it is not known if this risk is also relevant for vortioxetine.

Please note that not all possible side effects can be listed. If you experience any of these or any other unexpected side effects, seek medical attention promptly. 

Trintellix is indicated for the treatment of major depressive episodes in adults.

Read the manufacturer’s Product Insert leaflet that comes with the medication before using it.


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  • Is vortioxetine used for bipolar?

    Trintellix is prescribed as a first-line therapy to treat major depressive disorder (MDD). For patients with bipolar disorder, doctors can prescribe vortioxetine to address the depressive phase. Doctors will usually prescribe that it must be taken together with a mood stabilizer. Trintellix may cause mood changes in people with bipolar disorder, so a doctor may monitor more often for mood changes while taking Trintellix.
  • Is vortioxetine a mood stabilizer?

    Vortioxetine is what is known as a selective serotonin reuptake inhibitor (SSRI) and serotonin receptor modulator. It addresses major depressive disorder (MDD) and does not work the same way as lithium in treating bipolar disorder.
  • Can vortioxetine cause mania?

    Very few cases were reported where bouts of mania were directly attributable to Trintellix. However, it does not address mania or hypomania in bipolar disorder, so doctors usually prescribe medication along with Trintellix to control those phases of bipolar.
  • Does vortioxetine affect concentration?

    Studies on patients with Alzheimer’s disease showed that Trintellix produced improved cognitive function. Some other studies on adult patients with acute MDD showed that Trintellix had boosted their processing speed. It is believed that improving the balance of brain chemicals called neurotransmitters, that affect mood and emotions, also improves concentration.
  • Can you mix Trintellix with alcohol?

    When on a course of vortioxetine, it is essential to restrict alcohol intake. They both affect cerebral functions and can cause impairment when consumed together. Most doctors recommend avoiding alcohol altogether when taking Trintellix because it may also increase the risk of side effects.