Spend $99, get free U.S. shipping*

Tariff now required on U.S. shipments. Learn more »

Tel: 1-866-456-3768 Fax: 1-866-544-8993

For visual reference only; actual product may vary

  • US Name:

    Synvisc One

  • Alternative Names:

    Synvisc, Synvisc One

  • Active Ingredients:

    Hylan G-F 20

  • Brand Manufacturer:

    Sanofi Genzyme

  • Manufacturer Location:

  • Click here to view Product Insert

  • Click here to view Product Insert

  • Click here to view Product Insert

Synvisc One *

For visual reference only; actual product may vary

Prescription Required
All third-party products, company names, and logos are trademarks™ or registered® trademarks are and remain the property of their respective holders. Their use does not imply any affiliation with or endorsement by them. All references on this site to third-party trademarks are intended to constitute nominative fair use under applicable trademark laws.

Synvisc One is a single-injection treatment for relieving the pain of knee osteoarthritis. It contains hylan G-F 20, which lubricates and cushions the knee joint. This can provide pain relief for up to six months, helping you regain mobility and comfort. It is for patients who have not responded to other therapies.

Place your order

Synvisc One Brand -
6 mL
-
+
Our price:
$787.00

*Please note all prices are in US dollars

What is Synvisc One?

Synvisc One is a gel-like injection containing hylan G-F 20 used to treat knee pain from osteoarthritis. This treatment is a form of viscosupplementation. It replenishes the natural fluid in your knee joint. The active ingredient is derived from hyaluronan, a substance found naturally in the body. Synvisc One is administered in a single shot. This provides a convenient option for long-term pain management. The goal is to reduce pain and improve joint function. It helps patients return to their normal activities with less discomfort. This treatment is often considered when other therapies have failed.

How does Synvisc One work?

Synvisc One works by supplementing the natural synovial fluid in your knee. In an osteoarthritic knee, this fluid becomes thin and loses its shock-absorbing qualities. Synvisc One injects a gel-like substance directly into the joint space. This substance, hylan G-F 20, mimics healthy synovial fluid. It provides lubrication and cushioning for the joint. This helps the bones glide more smoothly over each other. The result is reduced friction, which is a major source of pain. The treatment does not reverse arthritis but can relieve its symptoms for up to six months. By restoring this protective layer, it improves mobility and reduces stiffness.

Who is Synvisc One for?

Synvisc One is intended for patients with knee osteoarthritis who have not found enough relief from other treatments. This includes individuals who have tried oral pain relievers like acetaminophen. It is also for those who did not benefit from non-drug therapies. Examples include physical therapy and exercise. The ideal candidate seeks a long-lasting, non-surgical solution for knee pain. Patients must not have allergies to avian products, such as eggs or feathers. This is because the active ingredient is derived from chicken combs. It is also not for people with infections in or around the knee joint.

Dosage and administration

Synvisc One is administered as a single injection directly into the knee joint by a healthcare professional. The entire treatment course is completed in one visit. Each pre-filled syringe contains 6 mL of hylan G-F 20 for one knee. Before the injection, a doctor may remove excess fluid from the knee. They may also use a local anesthetic to numb the area. After the injection, patients are advised to avoid strenuous activity for about 48 hours. This includes jogging, heavy lifting, or long periods of standing. The pain-relieving effects can last for up to six months. Treatment can be repeated if symptoms return.

Side effects

Synvisc One may cause temporary side effects, most commonly at the injection site. These reactions are usually mild and resolve within a few days. The most frequent side effects include pain, swelling, and warmth in the treated knee. Some people might also experience redness or stiffness. There can be a feeling of fluid buildup in the knee after the injection. Less common side effects can include headache, dizziness, or nausea. Serious allergic reactions are rare but possible. Seek immediate medical attention if you experience hives, facial swelling, or trouble breathing after the injection.

Why buy from IsraelPharm?

IsraelPharm provides a reliable and affordable way to purchase your Synvisc One prescription online. We are committed to making essential medications accessible to patients in the US. Our platform is secure and easy to use. It allows you to order your treatments from the comfort of your home. We source our products from trusted manufacturers, ensuring quality and authenticity. You can save money on brand-name medications like Synvisc One. Our customer service team is available to assist you with any questions. We provide a seamless ordering process and discreet delivery right to your door.

The most common side effects associated with Synvisc One are temporary and occur at the injection site. These may include:

  • Pain in the injected knee
  • Swelling, warmth, or redness
  • Stiffness in the joint
  • Accumulation of fluid in or around the knee

These reactions are generally mild and usually resolve on their own within a few days. More widespread but less common effects can include headache, dizziness, and muscle aches. Serious allergic reactions are rare.

Synvisc One is used for the treatment of pain in patients with osteoarthritis (OA) of the knee. It is indicated for individuals who have not received adequate relief from:

  • Simple pain relievers (e.g., acetaminophen)
  • Non-pharmacologic therapy such as exercise and physical therapy

Getting started with IsraelPharm

Required

Send Your Prescription

Secure Payment

No Hidden Fees

Fast Shipping

Generally 7-10 Business Days

Fast delivery
Secure payment
Genuine brands
Pharmacist oversight
Proudly Israeli

Ordering is
simple and safe.

IsraelPharm has been delivering lost cost prescriptions from Israel for over 15 years worldwide. Daily flights allow us to get your medications dispatched fast! Delivery to the USA is under 10 days and you can track and trace every order.

Read more from our blog

Login

Fast Delivery
Ships from Israel
Secure Payment
Genuine Brands
Pharmacist Oversight
Proudly Israeli
Free Shipping on orders over $99*

Having issues?

Daily from 9am-8pm EST.
IsraelPharm
Hataasia 16
Bet Shemesh Israel, 9906105

Sign up for $10 off your first order!

Enjoy exclusive deals we only share via email