Introducing Menopause Hormone Therapy
Menopause hormone therapy (MHT) is a new term for what used to be called hormone replacement therapy or HRT. If you’ve never heard about menopause hormone therapy, it’s worth remembering that the change of name
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For visual reference only; actual product may vary
US Name:
Stelara
Alternative Names:
Stelara
Active Ingredients:
Ustekinumab
Brand Manufacturer:
Janssen-Cilag
Manufacturer Location:
Switzerland
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For visual reference only; actual product may vary
Stelara (ustekinumab) is a prescription medication used to treat moderate to severe plaque psoriasis, active psoriatic arthritis, Crohn’s disease, and ulcerative colitis. It is an immunosuppressant that targets specific proteins in the body to reduce inflammation. This product is shipped cold.
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Stelara is a prescription immunosuppressant medication containing the active ingredient ustekinumab. It is a type of drug called a monoclonal antibody, which is a biologic therapy. This means it is made from living cells. Stelara is used to treat several autoimmune conditions where the body’s immune system attacks healthy tissue. The Food and Drug Administration (FDA) has approved it for treating plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis. It helps reduce inflammation and manage the symptoms associated with these chronic diseases.
Stelara works by targeting and blocking the activity of two specific proteins in the body. These proteins are called interleukin-12 (IL-12) and interleukin-23 (IL-23). In autoimmune diseases, the immune system produces too much of these proteins. This overproduction leads to high levels of inflammation, causing symptoms. By binding to IL-12 and IL-23, ustekinumab stops them from causing inflammation. This action helps to calm the immune system. It reduces the underlying inflammation of psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis, leading to fewer and less severe symptoms.
Stelara is for adults and children who have been diagnosed with specific autoimmune disorders. It is typically prescribed for patients with moderate to severe conditions. This includes adults and children with plaque psoriasis. It is also for adults with active psoriatic arthritis. Doctors may prescribe it for adults with moderately to severely active Crohn’s disease. Finally, it is for adults with moderately to severely active ulcerative colitis. Stelara is often used when other treatments have not worked well enough or were not tolerated.
Stelara dosage and administration depend on the patient’s weight and the condition being treated. It is administered as a subcutaneous injection, meaning it is injected just under the skin. A healthcare provider will typically administer the first dose. They may then teach you or a caregiver how to perform the injections at home. The dosing schedule usually starts with one or two initial doses. This is followed by maintenance doses every 8 or 12 weeks. Your doctor will determine the exact dose and frequency for your specific needs.
Stelara may cause side effects, though not everyone experiences them. Common side effects are often mild and manageable. However, more serious side effects can occur because Stelara affects the immune system. You should discuss all potential risks with your doctor.
Stelara can lower your ability to fight infections. This increases the risk of serious infections like tuberculosis (TB). Your doctor will test you for TB before starting treatment. Tell your doctor immediately if you notice signs of an infection, such as fever, cough, or skin sores. In rare cases, Stelara may increase the risk of certain cancers. A rare but serious condition called Reversible Posterior Leukoencephalopathy Syndrome (RPLS) has been reported, with symptoms like headache, seizures, confusion, and vision loss. Seek immediate medical help for any of these serious symptoms.
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Like all medicines, Stelara can cause side effects, although not everybody gets them. Many people experience no serious side effects.
Stelara can increase your risk of serious infections because it affects your immune system. This includes tuberculosis (TB) and infections caused by viruses, fungi, or bacteria. Your doctor should test you for TB before you start Stelara.
It may also increase the risk for certain types of cancer. You should inform your doctor about any new skin growths.
In rare cases, a serious condition affecting the brain called Posterior Reversible Encephalopathy Syndrome (PRES) can occur. Symptoms include headaches, seizures, confusion, and vision problems. Seek medical care immediately if you experience these.
Serious allergic reactions are also possible. Get emergency help if you have symptoms like faintness, swelling of the face or throat, or chest tightness.
Stelara is used for the treatment of the following conditions:
Stelara (ustekinumab) response times can vary depending on the condition being treated. For plaque psoriasis, many patients see significant skin improvement within 12 weeks of starting treatment. For Crohn’s disease and ulcerative colitis, some people may notice symptom relief after the first dose, but for others, it may take up to eight weeks or longer to experience the full benefits. Consistent use is key for best results.
Stelara is not a type of chemotherapy. Stelara is a biologic therapy known as a monoclonal antibody that selectively targets parts of the immune system. Chemotherapy is a different type of treatment that typically targets all rapidly dividing cells in the body, which is why it is used for cancer. Stelara works by specifically blocking proteins that cause inflammation in certain autoimmune diseases, making its action more targeted.
Stelara use during pregnancy or while breastfeeding should be discussed with your doctor. It is not known if Stelara can harm an unborn baby. The medication may be passed into breast milk. Your doctor will help you weigh the potential benefits of the treatment against the potential risks to your baby and make an informed decision based on your individual health needs.
If you miss a dose of Stelara, you should take it as soon as you remember. After that, you will need to adjust your schedule to get back on track. Contact your doctor or pharmacist to determine the best date for your next injection. Do not take two doses at once to make up for a missed one. Maintaining a consistent dosing schedule is important for the medication to work effectively.
Stelara must be stored in a refrigerator at a temperature between 36°F to 46°F (2°C to 8°C). It should be kept in its original carton to protect it from light. Do not freeze Stelara, and do not shake the pre-filled syringe or vial. If you are traveling, you will need to use a cool bag with ice packs to maintain the correct temperature for this cold-shipped product.
Stelara is not commonly associated with weight gain as a direct side effect in clinical trials. However, effective treatment for conditions like Crohn’s disease or ulcerative colitis can lead to better nutrient absorption and reduced symptoms like diarrhea. This improvement in overall health can sometimes result in a healthy weight gain as your body recovers. If you have concerns about weight changes, please consult your healthcare provider.
Stelara does not have a direct interaction with alcohol. However, alcohol can sometimes worsen symptoms of psoriasis or inflammatory bowel disease. It can also put extra stress on your liver. Since all medications carry risks, it is a good idea to limit alcohol consumption while on treatment. You should discuss your alcohol use with your doctor to see what is safe for you.
Stelara does suppress parts of your immune system. It works by blocking specific proteins that are involved in inflammation and immune responses. This action is what makes it effective for treating autoimmune diseases. However, this also means it can lower your ability to fight off infections. Your doctor will monitor you for any signs of infection while you are taking this medication.
Stelara may lower your immune system’s ability to respond, so you should not receive live vaccines while taking it. Live vaccines contain a weakened form of a virus or bacteria. Examples include the MMR (measles, mumps, rubella) and chickenpox vaccines. It is recommended to have all your required vaccinations up to date before starting your treatment. Always inform your doctor you are taking Stelara before receiving any vaccine.
Stelara is given as a subcutaneous injection, which can cause some discomfort. Most people experience only a brief, mild sting or burning sensation at the injection site, similar to other injections. To minimize pain, you can let the refrigerated medication sit at room temperature for about 30 minutes before injecting. Choosing a different injection site each time can also help reduce irritation.
The main purpose of Stelara is to treat chronic autoimmune conditions by reducing inflammation. It is specifically approved for moderate to severe plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis. Stelara helps to manage the symptoms of these diseases, such as skin lesions, joint pain, and digestive tract inflammation, especially when other medications have not been effective enough for the patient.
Stelara should not be taken by individuals who have a known allergy to ustekinumab or any of its other components. You should also not take it if you have an active, serious infection. Your doctor will test for tuberculosis before prescribing it. Tell your doctor if you have a history of cancer, are pregnant or breastfeeding, or are scheduled to receive a live vaccine before you start treatment.
Stelara is administered through a subcutaneous injection, which means it is injected into the fatty tissue just under the skin. Common injection sites include the thighs, abdomen, or upper arms. A healthcare provider gives the first dose and may train you to self-inject at home. The frequency of these injections depends on the condition being treated, typically occurring every 8 or 12 weeks after the initial starting doses.
The most common side effects of Stelara are generally mild. They can include symptoms of an upper respiratory infection, such as a sore throat or runny nose. Headaches, tiredness, and redness or pain at the injection site are also frequently reported. While most side effects are not serious, you should always report any persistent or bothersome symptoms to your doctor for further evaluation.
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