How long does Slenyto take to work?

Slenyto should be taken about 30 minutes before bedtime. Many children begin to fall asleep more quickly on the first or second night of treatment. The prolonged-release design helps maintain sleep through the early morning. It may take one to two weeks of consistent use for the full effect, as the body adjusts to a more regular sleep rhythm.

Is Slenyto safe for long-term use?

Slenyto has been used safely in clinical studies for up to 13 weeks, with ongoing monitoring recommended. Longer-term use can be appropriate when bedtime insomnia continues, but regular review is essential. Oversight ensures it remains effective and does not interfere with puberty or natural sleep development. Any emerging side effects or concerns should be discussed with a healthcare provider.

What is melatonin prolonged-release?

Melatonin prolonged-release is a tablet designed to release melatonin slowly overnight, matching the body's natural hormone pattern. It helps initiate sleep and sustain it through the night. This formulation supports the natural circadian rhythm, reducing nighttime awakenings and improving morning alertness.

Can melatonin tablets affect puberty or growth?

There is limited evidence on the long-term impact of melatonin on puberty and growth. While prolonged-release melatonin is generally well tolerated in children, ongoing monitoring by a healthcare provider is advised. If signs of puberty delay or other development concerns appear, the provider may review the dose or consider a treatment break.

How does Slenyto help children with autism and sleep problems?

In children with autism, natural melatonin production and release timing can be disrupted. Slenyto mimics the natural overnight release, helping to regulate the sleep-wake cycle, reduce difficulty in falling asleep, and improve night-time rest. Better sleep can lead to improved behavior, mood, attention, and overall well‑being during the day.

Can Slenyto be used for other sleep issues?

Slenyto is only approved for sleep-onset insomnia in children and adolescents with autism spectrum disorder or Smith‑Magenis syndrome. It is not indicated for insomnia in adults, other causes of sleep disruption, or different medical categories. Use in other sleep disorders would be considered off-label and requires specialist advice.

When is a prolonged-release melatonin preferred over immediate-release melatonin?

Prolonged-release formulations are preferred when a sustained hormone signal through the night is needed, such as in children with neurodevelopmental conditions. They help both initiate and maintain sleep. Immediate-release melatonin works faster but may not prevent early-morning waking.

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Home / Online Pharmacy / Slenyto

For visual reference only; actual product may vary

US Name:

Slenyto
Alternative Names:

Slentyo
Active Ingredients:

Melatonin
Brand Manufacturer:
Manufacturer Location:

Switzerland
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Slenyto ^*

For visual reference only; actual product may vary

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All third-party products, company names, and logos are trademarks™ or registered® trademarks are and remain the property of their respective holders. Their use does not imply any affiliation with or endorsement by them. All references on this site to third-party trademarks are intended to constitute nominative fair use under applicable trademark laws.

Slenyto is a hormonal sleep regulator used to help children aged 2 to 18 years with autism spectrum disorder or Smith-Magenis syndrome who have trouble falling asleep.

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Slenyto Brand	5mg 30 Tablets	- Slenyto – Brand, Slenyto, 5mg, 30, Tablets, 69208, Neurim, 2709 + 0	Our price: $180.00
Slenyto Brand	1mg 60 Tablets	- Slenyto – Brand, Slenyto, 1mg, 60, Tablets, 69207, Neurim, 2708 + 0	Our price: $85.00

*Please note all prices are in US dollars

Description
Side Effects
Indications
FAQ
Video

Slenyto (generic name: melatonin) is a hormonal sleep regulator used to help children aged 2 to 18 years with autism spectrum disorder or Smith-Magenis syndrome who have trouble falling asleep. It provides a form of artificial melatonin, a natural substance the body makes to control the sleep-wake cycle. This helps restore a more regular sleep rhythm, which many children in these groups struggle to maintain.

Slenyto belongs to the pharmacological class of prolonged-release melatonin formulations. It supports the body’s natural sleep cycle by providing a consistent low-level signal through the night. The formulation ensures a smooth and sustained release, aiming to minimize early-morning awakenings and daytime tiredness.

The cream-like tablets are made to release melatonin slowly overnight, helping the user fall asleep and stay asleep for several hours. This gradual release mimics the body’s own overnight signal, promoting better sleep quality and longer sleep duration. Slenyto is designed to reduce night-time awakenings and improve overall sleep regularity in children with neurodevelopmental conditions.

Dosage

It is important to follow the dosage instructions printed on the label of the box. Check with a doctor or pharmacist if there are any doubts regarding the proper dosage and treatment regimen. The usual starting dose of Slenyto is 2 mg each evening, taken 30 minutes before bedtime. For children who continue to have difficulty sleeping, the dose may be increased by the prescribing doctor by 1 mg at intervals of at least one week, up to a maximum of 5 mg per day. Tablets should be swallowed whole, not chewed or crushed, with a drink of water. If a dose is missed, it should not be taken the next day; instead, the next dose should be taken at the usual bedtime the following day.

Storage

Slenyto tablets should be stored in the original container between 15-25°C (59-77°F). The packaging should remain tightly closed, kept away from moisture and light, and out of reach and sight of children, especially since melatonin can affect natural sleep-wake cycles if used incorrectly. Refrigeration or freezing is not required. Any unused or expired tablets should be disposed of according to local guidelines.

This text is for informational purposes only. Please consult a doctor or pharmacist before using any medication.

Read the information leaflet that comes with the medication.

If a sudden allergic reaction (anaphylaxis) occurs shortly after taking Slenyto, with symptoms like swelling of the face, tongue, or throat making it difficult to breathe or swallow, or there is wheezing, hives, rash, blistering, or peeling of the skin, call a doctor or 911 right away, or go to an emergency room immediately.

Most people who use Slenyto do not experience any adverse side effects. Doctors prescribe this medication because they assess the benefits of such treatment outweigh any likely unwanted effects.

Some of the side effects that have been reported include:

headache
abdominal pain
dizziness
irritability
nightmares.

These are typically mild and most often seen in the first few weeks of use.

Serious side effects are rare but may include:

Daytime drowsiness or sleepiness, which could indicate excessive dosing; dose adjustment or administration earlier in the evening may help.
Mood swings, agitation, or depression, which require prompt medical follow-up.

Not all side effects are listed here. If these or other unlisted symptoms persist or worsen, consult a healthcare provider or pharmacist.

Slenyto treats sleep-onset insomnia in children and adolescents aged 2 to 18 who have autism spectrum disorder (ASD) or Smith-Magenis syndrome (SMS). Sleep-onset insomnia involves difficulty falling asleep, delayed bedtime, and insufficient night-time rest, which can worsen daytime behavior, concentration, and mood. The prolonged-release formulation helps align sleep patterns to more natural rhythms. Slenyto is not indicated for adults or children without these conditions. It is specifically used when sleep problems are linked to ASD or SMS and when behavioral and environmental approaches have not been sufficient.

Slenyto should be taken about 30 minutes before bedtime. Many children begin to fall asleep more quickly on the first or second night of treatment. The prolonged-release design helps maintain sleep through the early morning. It may take one to two weeks of consistent use for the full effect, as the body adjusts to a more regular sleep rhythm.
Slenyto has been used safely in clinical studies for up to 13 weeks, with ongoing monitoring recommended. Longer-term use can be appropriate when bedtime insomnia continues, but regular review is essential. Oversight ensures it remains effective and does not interfere with puberty or natural sleep development. Any emerging side effects or concerns should be discussed with a healthcare provider.

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All third-party products, company names, and logos are trademarks™ or registered® trademarks are and remain the property of their respective holders. Their use does not imply any affiliation with or endorsement by them. All references on this site to third-party trademarks are intended to constitute nominative fair use under applicable trademark laws.

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