Saphris (asenapine) is an atypical antipsychotic psychiatric medication used to treat certain mental/mood disorders (such as schizophrenia, bipolar disorder). Common side effects of Saphris include:

• drowsiness,
• dizziness,
• numbness or tingling of the mouth,
• restlessness,
• constipation,
• dry mouth,
• sleep problems (insomnia),
• upset stomach, and
• weight gain.

Saphris may cause muscle/nervous system problems (extrapyramidal symptoms-EPS). Tell your doctor if you notice the following side effects of Saphris including:

• feelings of anxiety/agitation/jitteriness,
• drooling or trouble swallowing,
• constant need to move,
• shaking (tremor),
• shuffling walk,
• stiff muscles,
• severe muscle spasms or cramping (such as twisting neck, arching back, eyes rolling up), and
• mask-like expression of the face.