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  • US Name:


  • Israeli Names:


  • Active Ingredients:

    Asenapine as Maleate

  • Brand Manufacturer:


  • Manufacturer Location:



Indicated in the treatment of schizophrenia and bipolar disorder


SAPHRIS is indicated for the treatment of schizophrenia in adults. The efficacy of SAPHRIS was established in two 6-week trials and one maintenance trial in adults Bipolar Disorder Monotherapy: SAPHRIS is indicated for the acute treatment of manic or mixed episodes associated with bipolar I disorder. Efficacy was established in two 3-week monotherapy trials in adults Adjunctive Therapy: SAPHRIS is indicated as adjunctive therapy with either lithium or valproate for the acute treatment of manic or mixed episodes associated with bipolar I disorder. Efficacy was established in one 3-week adjunctive trial in adults.

Saphris (asenapine) is an atypical antipsychotic psychiatric medication used to treat certain mental/mood disorders (such as schizophrenia, bipolar disorder). Common side effects of Saphris include:

  • drowsiness,
  • dizziness,
  • numbness or tingling of the mouth,
  • restlessness,
  • constipation,
  • dry mouth,
  • sleep problems (insomnia),
  • upset stomach, and
  • weight gain.

Saphris may cause muscle/nervous system problems (extrapyramidal symptoms-EPS). Tell your doctor if you notice the following side effects of Saphris including:

  • feelings of anxiety/agitation/jitteriness,
  • drooling or trouble swallowing,
  • constant need to move,
  • shaking (tremor),
  • shuffling walk,
  • stiff muscles,
  • severe muscle spasms or cramping (such as twisting neck, arching back, eyes rolling up), and
  • mask-like expression of the face.


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