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Ryeqo is prescribed to manage the symptoms of uterine fibroids and endometriosis in women of childbearing age.

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Ryeqo Brand 40/1/0.5mg
84 Tablets
Our price: $633.00
Ryeqo Brand 40/1/0.5mg
28 Tablets
Our price: $220.00

*Please note all prices are in US dollars
Ryeqo (generic names: relugolix/estradiol hemihydrate/norethindrone) is an oral medication that can be prescribed for the treatment of moderate to severe symptoms of uterine fibroids and endometriosis-associated pain in adult women. Relugolix belongs to a class of drugs known as gonadotropin-releasing hormone (GnRH) receptor antagonists. It works by lowering the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This reduces the production of estrogen and progesterone by the ovaries, which play a crucial role in producing conditions like uterine fibroids and endometriosis. To counter the side effects of prolonged estrogen suppression, estradiol (a form of estrogen) and norethindrone (a form of progesterone) are included in each dose of Ryeqo to maintain hormone balance and reduce the associated risks of osteoporosis. Ryeqo provides significant advantages in the management of conditions like uterine fibroids and endometriosis, which can severely impact a woman’s quality of life. Enabling the management of these conditions can reduce the need for more invasive treatments like surgery.


The recommended dose for Ryeqo is one tablet taken with a little liquid every day, at about the same time, with or without food.

This text is for informational purposes only. Please consult your doctor or pharmacist before using any medication.

The most commonly reported side effects include hot flashes, headache, fatigue, and insomnia. If these persist or worsen, ask a doctor or pharmacist for guidance.

Ryeqo can be prescribed to treat two conditions in women of childbearing age:

  • Uterine fibroids, which are non-cancerous growths in the uterus, more often occur during childbearing years.  During menstrual periods, there may be heavy menstrual bleeding and severe cramps. Other symptoms can include feelings of pressure in the lower abdomen, the need for frequent urination or difficulty in emptying the bladder, and constipation. These may be caused by the presence of large fibroids, which can press against other bodies in the abdomen.
  • Endometriosis, which can cause dysmenorrhea (severe pelvic pain), fatigue, diarrhea, constipation, bloating, or nausea during menstruation. It can also result in menstrual irregularities or painful sexual intercourse.
  • Is Ryeqo a GnRH?
    Ryeqo contains doses of estrogen and progestogen compared to combined contraceptives. It is combined with relugolix, which's a receptor antagonist for gonadotropin releasing hormone (GnRH). This combination helps suppress the production of estrogen and progesterone in the ovaries.
  • How long can you take Ryeqo for?
    You can take Ryeqo continuously without any breaks. However it is advisable to consider discontinuation when entering menopause as uterine fibroids tend to regress during this phase. It is recommended to undergo a DXA scan after one year of treatment.
  • Is Ryeqo a contraceptive?
    Yes, Ryeqo provides contraception after one month of use. If you miss two or more doses it is important to use hormonal contraception for at least seven days following the initiation of treatment. Ryeqo can also be prescribed for treating symptoms associated with fibroids.
  • Does Ryeqo stop periods?
    For women using Ryeqo there will be no menstrual bleeding (period) during treatment and for a few weeks afterward. Prior to prescribing it your doctor will discuss your family history as well as check blood pressure and ensure that you are not pregnant. There are medications known as gonadotropin releasing hormone (GnRH) agonists and antagonists that are used to reduce the levels of estrogen and progesterone in the body. This helps in shrinking fibroids and decreasing bleeding. Additionally GnRH agonists also prevent ovulation, reduce the size of the uterus and halt periods.

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