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  • US Name:


  • Israeli Names:

    Acnelyse Cream, Retavit Cream, Retavit Gel, Retin A cream

  • Active Ingredients:


  • Brand Manufacturer:

    Janssen Cilag

  • Manufacturer Location:



Tretinoin is a form of vitamin A used in the treatment of acne.

Prescription Required
Acnelyse Cream
0.025% 20g
1 Tube
Acnelyse Cream
0.05% 20g
1 Tube
*Please note all prices are in US dollars

Acnelyse is manufactured in Turkey. It is not known exactly how tretinoin works, but it is thought to loosen the cells in the surface of the skin. This helps to unblock pores, so that the skin’s natural oil producing glands can function normally. In addition, tretinoin increases the turnover of the skin cells, which aids the natural exfoliation of the outer layers of skin. This also helps to unblock pores and decrease the formation of blackheads (comedones) and spots.

More common
Burning, itching, stinging, scaling, or redness of the skin.
chapping or slight peeling of the skin (mild)
darkening of the skin.
lightening of normal skin color.
lightening of treated areas of dark skin.
redness of skin (mild)
unusual dryness of skin (mild)
unusually warm skin (mild)

Naturally occurring retinoid analog; also known as all-trans-retinoic acid (aTRA)
Oral form used in acute promyelocytic leukemia; topical form used for cutaneous disorders like acne and photoaging
Treatment with oral form may cause acute promyelocytic leukemia differentiation syndrome

Altinac, Altreno, Atralin, AVITA, Refissa, Renova, Retin-A, Retin-A Micro, Tretin-X, Vesanoid

  • What does tretinoin do for the skin?

    Renova (tretinoin) is used to treat acne or other skin diseases as determined by the treating doctor. Tretinoin cream is usually prescribed to treat damage to facial skin caused by the sun's damaging rays, and to clear acne by unblocking pores and decreasing the formation of blackheads (comedones) and spots.
  • What is the difference between retinol and tretinoin?

    Renova (tretinoin) is a synthetic Vitamin A formulated to treat acne. Retinol (also called vitamin A1) is a naturally derived fat-soluble member of the vitamin A family. Renova is significantly stronger than retinol.
  • Is it best to use tretinoin every night?

    Always follow the prescribing doctor’s instructions. In general, it is recommended to use Renova every night, but when first starting to use it, to avoid side effects, a doctor or pharmacist can advise what dosing frequency and pattern is best. It is essential only to use tretinoin as prescribed.
  • How long should I leave tretinoin on my face?

    It is generally advised to avoid washing the area of skin treated with tretinoin for at least one hour after applying it. Also, avoid using topical creams or oils on the same area within an hour before and after using Renova.
  • What is the best routine for tretinoin?

    Most doctors prescribe Renova at night before bed and to start slowly. Initially, the usual routine is to use a small dose twice or three times weekly. As the skin gets accustomed to the treatment, dosage and frequency can be increased. Always follow instructions.


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