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  • US Name:

    Prolia

  • Generic Names:

    Prolia

  • Active Ingredients:

    Denosumab

  • Brand Manufacturer:

    Amgen

  • Manufacturer Location:

    Netherlands

  • Click here to view Product Insert

  • Click here to view Product Insert

Prolia

Prescription Required

Prolia is prescribed to treat osteoporosis in people with prostate or breast cancer.

Prolia® is a trademark of Amgen and all questions regarding the name Prolia® should be addressed to Amgen at prolia.com

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Prolia Brand 60mg
1 Vial
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Our price: $480.00

*Please note all prices are in US dollars
Prolia (generic name: denosumab) is a human monoclonal antibody for the prevention of bone loss (osteoporosis) in postmenopausal women and in men who have a reduction in testosterone levels caused by surgery or treatment. It is also prescribed to prevent bone fractures in people with prostate or breast cancer who are undergoing treatment or with bone loss associated with long-term systemic glucocorticoid therapy with prednisone, where they are expected to remain on glucocorticoids for at least three months.

Caution

Women of childbearing age should use a barrier method of contraception while being treated with Prolia and for at least five months after stopping treatment. In case you become pregnant during treatment with Prolia or within five months after stopping treatment, please inform your doctor.  

Dosage

Prolia is administered by professional healthcare providers. The recommended dosage is one dose administered once every six months as a single subcutaneous injection. Please follow the doctor’s instructions and read the information in the manufacturer’s product leaflet that comes with the medication. Denosumab can carry serious health risks.

This text is for informational purposes only. Please consult your doctor or pharmacist before using any medication.

Possible side effects of Prolia include:

  • low calcium levels (especially if kidney problems are present)
  • weakness
  • constipation
  • back pain
  • muscle pain
  • pain in the arms and legs
  • anemia
  • diarrhea
  • skin problems (eczema, blisters, dry skin, peeling, redness, itching, small bumps)

While taking Prolia, there may be a greater likelihood of a severe infection, such as a skin, ear, stomach/gut, or bladder infection.

Inform a doctor immediately if there are signs of infection while taking the medication, such as:

  • fever/chills, night sweats
  • red/swollen/tender/warm skin
  • severe stomach or abdominal pain
  • ear pain or drainage, trouble hearing
  • frequent/painful/burning urination, or pink/bloody urine
  • severe itching, burning, rash, blistering, peeling, or dryness of the skin
  • cough or shortness of breath
  • pinpoint purple or red spots under your skin
  • flu symptoms
  • weight loss

 

Not all possible side effects can be listed here. If you experience any of these or other unexpected side effects, consult a healthcare provider immediately.

Prolia is a form of the generic drug denosumab that has been approved for the reduction of the risks of bone fractures in people with:

  • Postmenopausal osteoporosis
  • Osteoporosis in men treated with surgery or medication for prostate cancer with resulting androgen deprivation
  • Bone loss associated with long-term systemic glucocorticoid therapy
  • Bone loss in women with breast cancer due to aromatase inhibitor-induced estrogen depletion (low estrogen levels)

Postmenopausal women and men with reduced levels of testosterone have an increased risk of spinal, non-spinal, and hip fractures.

  • Can Prolia rebuild bone?
    In clinical trials, Prolia was shown to help strengthen bone and increase bone mass. It also helped to reduce the incidence of vertebral, nonvertebral, and hip fractures in postmenopausal women with osteoporosis.
  • When should the use of denosumab be avoided?
    It may be suggested to avoid the use of Denosumab during pregnancy as denosumab may cause some harm to a fetus. Advising the prescribing doctor of the possibility of pregnancy during the course of treatment is very important. Prolia has been reported as causing a severe condition of the jaw bone known as osteonecrosis of the jaw (ONJ). If dental surgery or treatment is scheduled while receiving this medication, the responsible healthcare professional should be informed in advance that this medication is currently being used.
  • What precautions are necessary when being treated with denosumab?
    The prescribing doctor should be aware of all other medications being taken (including over-the-counter drugs, vitamins, or herbal remedies). It’s crucial to not take aspirin or products containing it unless the doctor is aware and permits it.
  • Is pregnancy allowed while being treated with denosumab?
    The prescribing healthcare professional must be made aware before starting this treatment if you are pregnant or planning to become pregnant. Use of denosumab is permitted only if the benefit to the mother outweighs the risk to the fetus. Otherwise, both men and women should avoid conception while taking denosumab. The use of barrier methods of contraception, such as condoms, is recommended.
  • Is denosumab allowed while breastfeeding?
    It is not yet known whether denosumab is excreted into human milk. Because there may be a potential for severe adverse reactions in infants from denosumab, the decision should be to either discontinue nursing or discontinue the drug while taking into account the importance of denosumab to the mother.

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