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    Conjugated Estrogens

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Premarin tablets (generic name: conjugated estrogens) provide hormone replacement therapy that can help to reduce the adverse effects of menopause, such as hot flashes and osteoporosis. The tablets come in three strengths  – 0.3mg, 0.625mg and 1.25mg.

28 Tablets
28 Tablets
28 Tablets
*Please note all prices are in US dollars

Premarin conjugated estrogen tablets can be used to alleviate osteoporosis and the symptoms of hot flashes that may arise with menopause or after removal of the uterus. 

During the menopause, the levels of estrogen in the body decrease. This may lead to a sensation of increased heat over the face, neck, and chest (hot flashes). 

As well, women in menopause run higher risks of developing osteoporosis (bone density loss) that can result in the increased risk of fractures.

The usual recommended treatment for these conditions is known as hormone replacement therapy (HRT) or sometimes postmenopausal hormone therapy. HRT works by replenishing the diminishing levels of estrogen hormone in menopausal women. HRT also works to regulate secretions of luteinizing hormones (LH) and follicle-stimulating hormones (FSH) that are involved in the menstrual cycle and are necessary for regular sexual function. This helps to alleviate the symptoms of menopause.

Premarin is a member of the class of drugs known as estrogen derivatives, which contain conjugated estrogens and provide the hormone replacement required in HRT. It works by supplying the estrogen hormones that have been reduced in menopausal women. It will alleviate both the symptoms known as hot flashes, and will supplement the overall levels of estrogen in order to prevent osteoporosis.

Benefits of Premarin

Premarin is one of the main drugs used to deliver hormonal replacement therapy for women in menopause. As published by the independant organization Women’s Health Concern, it has been established that “it remains the most effective solution for the relief of menopausal symptoms and is also effective for the prevention of osteoporosis. It may in certain age groups provide protection against heart disease.”

Directions for use of Premarin conjugated estrogen tablets.

If a tablet is forgotten, it should be taken as soon as you realize this, and regular therapy should then be continued. If you forget more than one tablet, do not make up all of the missed dosage, but rather take the one most recently forgotten – do not double-up on the usual dose to make up for missed tablets as this could cause breakthrough bleeding in a woman with a uterus.


Make sure that your prescribing physician is aware of any of the following pre-existing conditions:

  • Leiomyomas  (fibroids inside the womb)
  • Endometriosis (growth of the womb lining outside the womb)
  • Endometrial hyperplasia (thickening of the womb lining)
  • Blood-clotting disorders
  • If you have a family history of breast cancer, there is an increased risk of estrogen-sensitive cancer
  • Hypocalcemia (low calcium levels in the blood)
  • Lipid disorders (high levels of fat in the blood).

Premarin conjugated estrogen tablets may increase the risk of endometrial hyperplasia and endometrial cancer. In such cases, the doctor may also prescribe progesterone to minimize this.

Inform your doctor if you are pregnant or breastfeeding. If you become pregnant while taking the tablets, you should stop immediately, and consult with your physician.


Interactions with other drugs

Your doctor will have taken into account the known interactions with other prescribed drugs, such as anticonvulsants, antibiotics, corticosteroids, and medicines for treating tuberculosis, HIV, and other conditions. However, tell the doctor if you are using non-prescription preparations (especially a herbal preparation such as St. John’s wort [Hypericum perforatum]).

Refrain from eating grapefruit or drinking grapefruit juice while using this medicine. This fruit can increase the risk of side effects.

Interactions with other diseases and conditions

Premarin conjugated estrogen is contraindicated in conditions such as endometrial cancer, unexplained vaginal bleeding, breast cancer, untreated endometrial hyperplasia, deep vein thrombosis or pulmonary embolism (both of which are blood clotting disorders), or for people with a history of heart attack or angina (chest pain), liver disease, or a family history of the blood disorder porphyria.

Lifestyle advice

Avoid consumption of alcohol during the period of use, as it may increase the risk of side effects.

Use of Premarin conjugated estrogen tablets is not recommended for pregnant women as it may cause fetal abnormalities. As well, because the drug can pass into breast milk, it is not recommended for breastfeeding mothers.

When taking any blood tests, inform the doctor that you are taking Premarin conjugated estrogen tablets as the medicine may affect some test results.

Some common side effects of Premarin conjugated estrogen tablets may include:

  • Breast pain
  • Changes in the menstrual cycle
  • Breakthrough bleeding
  • Nausea
  • Flatulence
  • Stomach pain
  • Headache
  • Pelvic pain
  • Back pain
  • Depression
  • Insomnia or sleep problems

Generally, these are mild and should clear within a few weeks of the commencement of treatment. However, if they persist, or worsen, consult with the prescribing physician as soon as possible.

There are rare but more serious side effects, including:

  • Breast lumps
  • Unusual and persistent vaginal bleeding
  • Changes in vision or speech
  • Sudden onset of severe headaches
  • Severe pains in the chest or legs, which may be accompanied by shortness of breath, weakness and fatigue
  • Swelling of the lips, tongue or face

If you experience any of these symptoms, discontinue use of the tablets immediately, and consult with your family physician as soon as possible.

Premarin conjugated estrogen tablets can be used to alleviate osteoporosis and the symptoms of hot flashes that may arise with menopause or after removal of the uterus. 


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