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  • US Name:

    Premarin Vaginal Cream

  • Israeli Names:


  • Active Ingredients:

    Conjugated Estrogens

  • Brand Manufacturer:


  • Manufacturer Location:

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Premarin Vaginal Cream

Premarin Vaginal Cream is a cream that boosts estrogen levels, to help reduce vaginal symptoms of menopause.

Prescription Required
Premarin Vaginal Cream
30 Grams
*Please note all prices are in US dollars

Premarin Vaginal Cream (generic name: conjugated estrogens vaginal cream) delivers hormone replacement therapy that can help reduce the adverse effects of declining estrogen levels, especially after menopause. It is applied directly inside the vagina to treat dryness, irritation or burning, and painful intercourse. It can also be prescribed to reduce the development of postmenopausal osteoporosis.

When treating only vaginal symptoms of menopause, applying supplementary estrogen in hormone replacement therapy (HRT) via a vaginal cream is generally considered safer than oral, injected or topical skin medications that carry a greater risk of side effects due to excess estrogen being absorbed.

Premarin Vaginal Cream can also be prescribed to alleviate the risk of menopausal osteoporosis.

Premarin Vaginal Cream is a member of the class of drugs known as estrogen derivatives, which contain conjugated estrogens and provide the hormone replacement required in HRT. It works by supplying the estrogen hormones that have been reduced in menopausal women. It will alleviate both the symptoms associated with the changes in and around the vagina, and will supplement the overall estrogen levels to prevent osteoporosis.

As published by the independent organization Women’s Health Concern, it has been established that “it remains the most effective solution for the relief of menopausal symptoms and is also effective for the prevention of osteoporosis. It may, in certain age groups, protect against heart disease.”

Special benefits of Premarin Vaginal Cream

Premarin cream delivers multiple benefits. Firstly, the cream directly soothes the affected areas around the vagina that have become irritated, dry or inflamed due to the fall in levels of estrogen. As well, it is delivering supplemental estrogen to alleviate the causes of these symptoms, as well as to prevent the onset of osteoporosis.


The dosage is based on each patient’s medical condition and response to the treatment. The dosage the doctor prescribes should be carefully followed. Do not alter the frequency or strength without consulting a healthcare professional. Take care to follow the instructions for applying the cream as supplied in the patient leaflet. If a dose is missed, only make it up if there is at least twelve hours before the next dose. Do not double dose to make up a missed dose. Overdosage with estrogens may cause nausea and vomiting, breast discomfort, fluid retention, bloating or vaginal bleeding.

Interactions with other drugs

Tell the doctor if you are using non-prescription preparations (especially a herbal preparation such as St. John’s wort [Hypericum perforatum].)

Refrain from eating grapefruit or drinking grapefruit juice while using this medicine. This fruit can increase the risk of side effects.

Lifestyle advice

Avoid consumption of alcohol during the period of application, as it may increase the risk of side effects.

Premarin Vaginal Cream is not recommended for use in pregnant women as it may cause fetal abnormalities. As well, because the drug can pass into breast milk, it is not recommended for breastfeeding mothers.

When taking blood tests, inform the doctor that you are taking Premarin Vaginal Cream, as the medicine may affect some test results.

Some mild side effects have been reported. These may include:

  •  Breast pain, leaking of milk from the nipple
  •  Inflammation of the vagina, vaginal itching or discharge
  •  Breakthrough bleeding, spotting, changes in menstrual flow, painful periods
  •  Joint pain, leg pain
  •  Hair loss
  •  Changes in weight (increase or decrease)
  •  Nausea, vomiting, bloating, abdominal pain
  •  Dizziness
  •  Headache (including migraine)
  •  Changes in libido
  •  Mood disturbances, irritability
  •  Rash, itching, hives, tender red nodules on the shins and legs, acne.

Tell your doctor, nurse or pharmacist if any of these affects you severely.

Sometimes, more serious side effects have been reported. In such a case, stop taking the medication and talk immediately with a healthcare professional. The side effects are:

  • Nausea and vomiting that doesn’t stop
  • mood changes, depression, or memory loss
  • breast lumps
  • unusual vaginal bleeding such as spotting, breakthrough bleeding, prolonged or recurrent bleeding
  • increased or new vaginal irritation, itching, odor or discharge
  • severe stomach or abdominal pain
  • yellowing around the eyes or on the skin 
  • dark urine
  • swelling of the hands, ankles or feet
  • increased thirst
  • increased and more frequent urination.

There have been some cases of severe allergic reaction to this product. Get medical help immediately if symptoms like a rash, itching or swelling (especially of the face, tongue or throat), severe dizziness, or trouble breathing appear.

Premarin Vaginal Cream is prescribed as a hormone replacement therapy for women in menopause to treat vulvar and vaginal atrophy and kraurosis vulvae (itching, burning, dryness in or around the vagina, difficulty or burning on urination) associated with menopause. It is also prescribed to treat dyspareunia (pain during intercourse) associated with menopause. 

It can also be prescribed to reduce the development of postmenopausal osteoporosis.

During the menopause, the levels of estrogen in the body decrease. This may lead to a sensation of increased heat over the face, neck, and chest (hot flashes). 

As a result of lower estrogen levels, there may be changes inside the vagina and on the labia. The condition can cause sensations of dryness, itching or burning. It can also cause discomfort during sexual intercourse.

As well, women in menopause run higher risks of developing osteoporosis (bone density loss) that can result in the increased risk of fractures.

The usual recommended treatment for these conditions is known as hormone replacement therapy (HRT) or sometimes postmenopausal hormone therapy. HRT works by replenishing the diminishing levels of estrogen hormone in menopausal women. HRT also works to regulate secretions of luteinizing hormones (LH) and follicle-stimulating hormones (FSH) that are involved in the menstrual cycle and are necessary for regular sexual function. This helps to alleviate the symptoms of menopause.

  • What are the symptoms of low estrogen?

    Symptoms of low estrogen can include hot flashes and night sweats, mood swings and thinning of the tissues in the walls of the vagina and labia, causing discomfort, itching and irritation.
  • How long does it take for estrogen cream to help with dryness?

    Atrophic vaginitis is an inflammation and irritation of the vagina caused by thinning of the tissues in the walls of the vagina and decreased lubrication of the vaginal walls caused by lower estrogen levels in the blood. It can be treated with Premarin Vaginal Cream (conjugated estrogens), and it can take three to four weeks to yield maximum benefit.
  • When is the best time to insert estrogen cream?

    It is usually best to use it at bedtime. This reduces the chance of leakage of the cream. Premarin Vaginal Cream comes in a tube with a special applicator used to insert the cream into the vagina.
  • What happens if you use too much estrogen cream?

    Overdosage of Premarin Vaginal Cream can cause nausea, vomiting, breast tenderness, abdominal pain, drowsiness and fatigue, and withdrawal bleeding may occur in women. Treatment should be discontinued, and a healthcare provider should institute appropriate symptomatic care.
  • What happens when you stop using estrogen cream?

    Stopping any HRT suddenly should not be done without consulting a doctor. Effects of sudden withdrawal can be symptoms of estrogen withdrawal, including hot flashes and night sweats. Doctors can manage these symptoms by slowly decreasing the dose over time.


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