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  • US Name:

    Premarin Vaginal Cream

  • Israeli Names:


  • Active Ingredients:

    Conjugated Estrogens

  • Brand Manufacturer:


  • Manufacturer Location:

  • Click here to view Product Insert

Premarin Vaginal Cream

Premarin Vaginal Cream (generic name: conjugated estrogens vaginal cream) is a hormone replacement therapy that can help to reduce the adverse effects of menopause in the area of the vagina, such as dryness, irritation or burning, as well as painful intercourse. It will also reduce the development of osteoporosis.

Premarin Vaginal Cream
30 Grams
*Please note all prices are in US dollars

Premarin Vaginal Cream can be used to alleviate osteoporosis and the symptoms of vaginal discomfort that may arise with menopause. 

During the menopause, the levels of estrogen in the body decrease. This may lead to a sensation of increased heat over the face, neck, and chest (hot flashes). 

As a result of lower estrogen levels, there may be changes inside the vagina and on the labia. The condition can cause sensations of dryness, itching or burning. It can also cause discomfort during sexual intercourse.

As well, women in menopause run higher risks of developing osteoporosis (bone density loss) that can result in the increased risk of fractures.

The usual recommended treatment for these conditions is known as hormone replacement therapy (HRT) or sometimes postmenopausal hormone therapy. HRT works by replenishing the diminishing levels of estrogen hormone in menopausal women. HRT also works to regulate secretions of luteinizing hormones (LH) and follicle-stimulating hormones (FSH) that are involved in the menstrual cycle and are necessary for regular sexual function. This helps to alleviate the symptoms of menopause.

Premarin Vaginal Cream is a member of the class of drugs known as estrogen derivatives, which contain conjugated estrogens and provide the hormone replacement required in HRT. It works by supplying the estrogen hormones that have been reduced in menopausal women. It will alleviate both the symptoms associated with the changes in and around the vagina, and will supplement the overall levels of estrogen in order to prevent osteoporosis.

Benefits of Premarin

Premarin is one of the main drugs used to deliver hormonal replacement therapy for women in menopause. As published by the independant organization Women’s Health Concern, it has been established that “it remains the most effective solution for the relief of menopausal symptoms and is also effective for the prevention of osteoporosis. It may in certain age groups provide protection against heart disease.”

Special benefits of Premarin Vaginal Cream

Premarin cream delivers multiple benefits. In the first place, the cream directly soothes the affected areas around the vagina that have become irritated, dry or inflamed due to the fall in levels of estrogen. At the same time, it is delivering supplemental HRT estrogen to alleviate the causes of these symptoms, as well as to prevent the onset of osteoporosis.

Directions for use of Premarin Vaginal Cream.

Wash your hands before applying the cream and after use.

Wash and dry the affected area and then apply a thin layer of the cream to the affected area. Do not apply to open wounds or broken skin.



Interactions with other drugs

Your doctor will be aware of the known interactions with other prescribed drugs, such as anticonvulsants, antibiotics, corticosteroids, and medicines for treating tuberculosis, HIV, and other conditions. However, tell the doctor if you are using non-prescription preparations (especially a herbal preparation such as St. John’s wort [Hypericum perforatum].

Refrain from eating grapefruit or drinking grapefruit juice while using this medicine. This fruit can increase the risk of side effects.

Interactions with other diseases and conditions

Premarin Vaginal Cream is contraindicated in conditions such as endometrial cancer, unexplained vaginal bleeding, breast cancer, untreated endometrial hyperplasia, deep vein thrombosis or pulmonary embolism (both of which are blood clotting disorders), or for people with a history of heart attack or angina (chest pain), liver disease, or a family history of the blood disorder porphyria.

Lifestyle advice

Avoid consumption of alcohol during the period of application, as it may increase the risk of side effects.

Premarin Vaginal Cream is not recommended for use in pregnant women as it may cause fetal abnormalities. As well, because the drug can pass into breast milk, it is not recommended for breastfeeding mothers.

It helps to wear loose, layered clothing, especially in warm weather, to prevent hot flashes and sweating in the areas being treated by the hormonal cream.

When taking any blood tests, inform the doctor that you are taking Premarin Vaginal Cream as the medicine may affect some test results.

Some common side effects of Premarin Vaginal Cream may include:

  • Flushing around the affected areas (redness, warmth, or tingly feeling)
  • Vaginal itching or discharge
  • Breast pain
  • Changes in the menstrual cycle
  • Breakthrough bleeding
  • Nausea
  • Excess gas
  • Stomach pain
  • Headache
  • Pelvic pain
  • Back pain
  • Depression
  • Insomnia or sleep problems

Generally, these are mild and should clear within a few weeks of the commencement of treatment. However, if they persist, or worsen, consult with the prescribing physician immediately.

There are rare but more serious side effects, including:

  • Breast lumps
  • Unusual and persistent vaginal bleeding
  • Changes in vision or speech
  • Sudden onset of severe headaches
  • Severe pains in the chest or legs, which may be accompanied by shortness of breath, weakness and fatigue
  • Swelling of the lips, tongue or face

If you experience any of these symptoms, discontinue use of the cream immediately, and consult with your family physician as soon as possible.


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