Free shipping on orders over $99*

Tel: 1-866-456-3768  Fax: 1-866-544-8993



  • US Name:


  • Generic Names:


  • Active Ingredients:

    Estriol (E3)

  • Brand Manufacturer:


  • Manufacturer Location:


  • Click here to view Product Insert

  • Click here to view Product Insert


Prescription Required

Ovestin is a vaginal estrogen cream used to relieve vaginal symptoms such as soreness, dryness, and irritation

Place your order

Ovestin Brand 0.1%, 15gr
1 Tube
Our price: $25.00

*Please note all prices are in US dollars
Ovestin (estriol) treats estrogen deficiency that can cause vaginal disorders.  It is a vaginal estrogen cream that supplies estriol, a naturally occurring estrogen (sometimes referred to as oestrogen). Estriol has a selective action on the cervix, vagina, and vulva. Ovestin is used in compounded hormone replacement medications approved to treat symptoms of hormone deficiency in menopause or after surgical removal of the ovaries.
Ovestin vaginal cream contains the active ingredient estriol, which is one of the naturally occurring forms of the primary female sex hormone estrogen that is naturally found in the body.
Estrogens work by binding to estrogen receptors in the body. Estrogen receptor alpha (ERα) is primarily found in the vagina, breast tissue, and ovaries. Estriol can be used as hormone replacement therapy (HRT) for women after menopause, specifically targeting ERα receptors.
As an effective treatment, Ovestin is applied directly to the vagina in the form of vaginal cream. Studies have shown that when it comes to treating the vaginal symptoms of menopause like dryness and itching, creams applied directly to the affected area are more effective than any other estrogen therapy forms. They also have the advantage that they can relieve vaginal symptoms without exposing the entire body to high doses of estrogen and be a safe way for women who cannot take other therapies.


Follow the doctor’s instructions about when and how to use Ovestin. Ovestin comes with a clear plastic applicator. The normal dosage is to fill the applicator up to the ring mark and apply the full dose once each day for two to three weeks, and then twice a week. Applying the cream at night before bedtime is advised.

This text is for informational purposes only. Please consult with a doctor or pharmacist before using any medication. 

Read the manufacturer’s product information leaflet that comes with the medication.

Reported side effects include:

  • Menstrual cycle changes
  • Spotting
  • Dysmenorrhea
  • Breast tenderness
  • Nausea or vomiting
  • Headache
  • Weight gain
  • Hair loss
  • Vaginal itching
  • Bloating

Not all possible side effects are listed here. If these or other unlisted symptoms persist or worsen, consult a healthcare provider or pharmacist.


Estriol can also interact with grapefruit juice, which may increase the risk of side effects.

There may be some irritation or itching of the skin in or around the vagina when the use of Ovestin begins – this should clear up after a few days. If not, stop usage immediately and consult a doctor.

Refer to a doctor immediately if any of the following serious side effects are noticed:

  • Increased blood pressure
  • The skin or whites of the eyes become yellow (jaundice)
  • Suddenly developing migraine-type headaches
  • There are signs of a blood clot

The doctor may decide to discontinue the use of the cream.

Declining levels of estrogen often affect the labia and the vagina’s delicate lining and can cause dryness, inflammation or itching, and vaginal atrophy or thinning. The distressing symptoms may include an increased susceptibility to vaginal or urinary infections and uncomfortable or painful intercourse. The decline is a natural outcome of aging in women. Ovaries produce substantially lower levels of estrogen with the onset of menopause, resulting in estrogen deficiency.

Ovestin vaginal cream contains the active ingredient estriol, which is one of the naturally occurring forms of the primary female sex hormone estrogen that is naturally found in the body. It is required for the treatment of vulvovaginal complaints related to estrogen deficiency.

Estriol can be used as hormone replacement therapy (HRT) for women after menopause or the performance of a surgical procedure called an oophorectomy. The development of ovarian cysts and the risk of developing ovarian cancer are the most common reasons for having an oophorectomy.

  • How long can you stay on estriol cream
    Ovestin is a high-strength estradiol cream. It should be used for a single treatment period of a maximum of three to four months, unless a doctor recommends differently. The estrogen in the creams can be absorbed into the bloodstream and this may increase the risk of side effects.
  • Is it safe to use Ovestin every day?
    Usually, patients are instructed to apply Ovestin cream once per day for a fortnight, and after that, to gradually reduce the dosage to twice per week. Ovestin Cream takes a few weeks before it starts to work properly, and it needs to be used regularly to get proper results.
  • Can I apply Ovestin with my finger?
    If there is external itching and soreness around the vulva, it is OK to apply Ovestin cream with the fingertips.
  • What is the risk of Ovestin?
    Menopausal women have a small risk of developing endometrial cancer (cancer of the lining of the womb), whether or not they are receiving hormone replacement therapy (HRT). However, there is a slightly higher risk of developing endometrial cancer the longer the treatment with Ovestin continues. Spotting and breakthrough bleeding can occur, especially during the initial use of Ovestin.

Getting started with IsraelPharm


Send Your Prescription

Secure Payment

No Hidden Fees

Fast Shipping

Generally 7-10 Business Days

Fast delivery
Secure payment
Genuine brands
Pharmacist oversight
Proudly Israeli

Ordering is
simple and safe.

IsraelPharm has been delivering lost cost prescriptions from Israel for over 15 years worldwide. Daily flights allow us to get your medications dispatched fast! Delivery to the USA is under 10 days and you can track and trace every order.

Read more from our blog

Doctor and patient are discussing at clinic

Managing Herpes Infections

Herpes simplex viruses are a topic that can spark plenty of questions simply because they are incredibly common, affecting billions worldwide. But fear not! This blog is a friendly guide, providing clear information on most


Fast Delivery
Ships from Israel
Secure Payment
Genuine Brands
Pharmacist Oversight
Proudly Israeli
Free Shipping on orders over $99*

Having issues?

Daily from 9am-8pm EST.
IsraelPharm c/o SUBS Ltd. Ha'Uman 5 Bet Shemesh Israel, 9906105

Sign up for $10 off your first order!

Enjoy exclusive deals we only share via email