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  • US Name:

    Noxafil

  • Israeli Names:

    Noxafil

  • Active Ingredients:

    Posaconazole

  • Brand Manufacturer:

    MSD

  • Manufacturer Location:

    Canada

  • Click here to view Product Insert

Noxafil

Noxafil is used to prevent, restrict or stop fungal infections in patients who have severely weakened immune systems, such as the ones who have recently had chemotherapy. It can also be prescribed to treat Candida fungal infections in the mouth or throat.

BrandNoxafil Suspension40mg105 mL99999MSD1897
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$305.34
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Noxafil (generic name: posaconazole) is prescribed to prevent, restrict and treat fungal infections. It is available in three forms – oral suspension (40mg/mL), delayed-release tablets (100mg) and injectable solution (18mg/mL).

Oral suspension is used to treat the fungal infection of the mouth or throat called oral thrush (candidiasis). It may be used either as the initial treatment or after treatment with other antifungal medicines has failed. 

Delayed-release tablets are used to treat invasive aspergillosis. 

Noxafil is also prescribed to prevent certain yeast or fungus infections such as invasive aspergillus or candida in patients who have a weakened immune system. The reduced immunity may be in hematopoietic stem cell transplant (HSCT) recipients, or patients with blood cancers.

A few side effects have been reported as moderately frequent, and some have severe implications. They should be reported immediately to the prescribing medical health provider or pharmacist:

  • Changes in the blood, including reduced levels of potassium, decreased platelet counts, low levels of white neutrophils, thrombophlebitis (inflammation of a vein caused by a clot)
  • Trouble in breathing

Less severe side effects include muscle pain, dizziness, difficulty sleeping, low levels of energy, decreased appetite, headaches, coughing, nausea, vomiting or diarrhea. These should be reported to the doctor or pharmacist if they persist or get worse.

More infrequent side effects are:

  • Herpes simplex viral infection
  • High blood pressure or a fast heartbeat
  • Pneumonia
  • For women, bleeding unrelated to the menstrual period
  • Backache
  • Throat irritation
  • Indigestion or constipation
  • Itching
  • Joint pain
  • Excessive sweating
  • Chills
  • Small reddish-purplish spots anywhere on the skin
  • High blood sugar levels
  • Intense abdominal pain

These side effects should clear up within a few days. If they persist or get worse, consult with your healthcare provider or pharmacist.

Noxafil is prescribed for cases of invasive aspergillus and candida infections in patients who are at high risk of developing these infections due to being severely immunocompromised – for example patients who have been hematopoietic stem cell transplant recipients with acute graft versus host disease (GVHD) or having  hematologic malignancies with prolonged neutropenia from chemotherapy. In such cases, the Noxafil oral suspension, tablets or IV may be prescribed.

The duration of the therapy is based on recovery from neutropenia or immunosuppression.

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