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Lysodren can be used to treat a rare kind of cancer of the adrenal gland, as well as Cushing’s syndrome.

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Lysodren Brand 500mg
100 Tablets
Our price: $880.00

*Please note all prices are in US dollars
Lysodren (generic name: mitotane) is a drug used to treat adrenocortical cancer (ACC) and Cushing’s syndrome. Its primary application is in patients with persistent cancer that cannot be removed with surgery (unresectable), or which has returned after surgical resection (relapsed), or has spread to another section of the body (metastatic cancer). Lysodren targets the cortex of the adrenal gland, which produces some steroid hormones, such as cortisol. Overproduction of these hormones results in the symptoms of Cushing’s syndrome and ACC. Mitotane inhibits the functioning of the adrenal cells, and so reduces the production of the steroid hormones. It may also promote the breakdown of these hormones. Together, these effects reduce steroid hormone levels in the body, which improves disease symptoms.


Pregnant women should not use Lysodren as it might harm the unborn baby. For this reason, women who could become pregnant should use appropriate birth control measures during the treatment and consult with a doctor after taking the last dose.


The dose and regimen is set by the prescribing doctor. The usual starting dose for adults is two to three grams per day, divided into two or three doses, and taken with fatty meals. The dose for children is normally calculated based on the child’s height and weight. Patients who require immediate control of Cushing’s syndrome may be given a starting dose of four to six grams per day.


Keep the medicine in a closed container at room temperature out of the reach of children and pets. Do not use Lysodren after the expiry date. Read our tips on handling medicine safely.

This text is for informational purposes only. Please consult a doctor or pharmacist before using any medication.

Read the information leaflet that comes with the medication.

Most people who use Lysodren do not experience any negative side effects. Doctors prescribe Lysodren because they assess that the benefits that such treatment yields outweigh any likely unwanted effects.

There can be serious side effects, which should be referred back to the treating doctor because these may be indications of complications for which some remedial medications may be appropriate. The symptoms include:

  • Fatigue, abdominal pain, nausea, vomiting, diarrhea, confusion (signs of adrenal insufficiency)
  • Pale skin, muscular fatigue, breathlessness, vertigo (dizziness) mainly when rising from a sitting position (signs of anemia)
  • Yellowing of the skin and eyes, itching, nausea, diarrhea, fatigue, dark colored urine (indicative of liver damage)
  • Movement and coordination disorders, abnormal sensations like pins and needles (tingling), memory loss, loss of concentration, difficulty in talking, vertigo (indicative of neurological disorders)

Some of the common side effects that have been reported include:

  • Anorexia
  • Nausea
  • Diarrhea
  • Vomiting
  • Impaired memory

Not all side effects are listed here. If these or other unlisted symptoms persist or worsen, consult a healthcare provider or pharmacist.

The most common symptoms of Cushing syndrome are gaining weight the trunk or face, while still having thin arms and legs. There can be a fatty lump between the shoulders, or colored stretch marks on the stomach, hips, thighs, breasts and underarms. The skin can become thin and frail, and bruises easily, with slow wound healing. Acne can also break out.

The sypmtoms of ACC resemble some of the above, as well as trouble sleeping, pain in the abdomen or lower back, and weight loss or loss of appetite. In women, there can be a deepening voice and increased hair growth, usually on the face.

Adrenocortical cancer and Cushing’s syndrome can be diagnosed with blood tests to determine hormone levels, as well as imaging and saliva tests. Differentiating between adrenal cancer and Cushing’s syndrome requires a special test known as Liddle’s test.

  • Can I take Lysodren alone?
    Lysodren can be used alone or in combination with other chemotherapy medicines.
  • Do I need to perform a laboratory test while taking Lysodren?
    A laboratory test should be performed before and throughout treatment with Lysodren.
  • Should Lysodren be taken by pregnant women?
    Pregnant women shouldn’t handle Lysodren or breathe in the tablet dust since it can be absorbed through the skin and lungs and harm an unborn child.
  • Is Lysodren recommended during breastfeeding?
    Lysodren crosses into breast milk and may affect a nursing newborn. Breastfeeding isn’t recommended while using this medication or for a while after the final dosage. The doctor will do blood tests to determine when nursing can begin.

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