Amorolfine 5% nail lacquer in once-weekly or twice-weekly applications to treat toenail onychomycosis
|Brand||Loceryl||5% / 2.5ml||1 Bottle||71194||Galderma||1276||
Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes. Marketed as Curanail, Loceryl, Locetar, and Odenil, amorolfine is commonly available in the form of a nail lacquer, containing 5% amorolfine as the active ingredient. It is used to treat onychomycosis (fungal infection of the toe- and fingernails). Amorolfine 5% nail lacquer in once-weekly or twice-weekly applications has been shown in two studies to be between 60% and 71% effective in treating toenail onychomycosis; complete cure rates three months after stopping treatment (after six months of treatment) were 38% and 46%
Topical treatment of onychomycosis caused by dermatophytes, yeast, and molds.
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