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  • US Name:

    Leqvio

  • Generic Names:

    Leqvio

  • Active Ingredients:

    Inclisiran

  • Brand Manufacturer:

    Novartis

  • Manufacturer Location:

    Italy

  • Click here to view Product Insert

  • Click here to view Product Insert

Leqvio

Prescription Required

Leqvio treats hypercholesterolemia, which is a metabolic disorder that causes elevated levels of LDL (low-density lipoproteins) in the blood. It is only available for injection by a healthcare professional.

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Leqvio Brand 284mg
1 Pre-Filled Syringe
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Our price: $3,212.00

*Please note all prices are in US dollars
Leqvio (inclisiran) is prescribed as a treatment for primary hypercholesterolemia, which is a metabolic disorder that causes elevated levels of LDL (low-density lipoproteins). This can lead to the development of arteriosclerosis resulting in cardiac failure. Inclisiran lowers the levels of LDL (“bad” cholesterol), which can cause heart and blood circulation problems. It is usually used along with dietary controls and can be combined with other lipid-lowering therapies in patients who are unable to reach LDL cholesterol goals with the maximum tolerated dose of a statin, or who are statin-intolerant, or for whom a statin is contraindicated.

Dose and usage

Leqvio must be used only under the direction of the prescribing doctor. It must be administered as a subcutaneous injection by a healthcare professional. The initial dose of Leqvio is usually 284 mg given by injection, followed by one injection after 3 months, and then further doses every 6 months.

This text is for informational purposes only. Please consult a doctor or pharmacist before using any medication. 

Read the information leaflet that comes with the medication.

Most people who use Leqvio do not experience any negative side effects. Doctors prescribe Leqvio because they assess that the benefits that such treatment yields outweighs any likely unwanted effects.

There are few side effects from Leqvio. Those that have been reported include injection site reactions, such as pain, redness, or rash.

Not all side effects are listed here. If these or other unlisted symptoms persist or worsen, consult a healthcare provider or pharmacist.

Blood tests measure low density lipoprotein (LDL) levels. Between 130 and 159 mg per dL is borderline high. Higher than 160 mg per dL is high, and over 190 mg per dL is extremely high. Treatment with standard statins may be insufficient for high or very high LDL patients, and some people either cannot tolerate statins, or have severe reactions. Leqvio may be prescribed either as a stand-alone therapy in such cases, or as an adjunct to statins. It is always required to be used along with a controlled diet that limits the intake of fats.

  • How does Leqvo affect blood cholesterol levels?
    Inclisiran interferes with genetic transport molecules (RNA) to limit the production of the PCSK9 protein. PCSK9 can increase LDL cholesterol levels, so by preventing its production, Leqvio helps to lower LDL cholesterol levels.
  • What are the different types of hypercholesterolemia?
    Genetic hypercholesterolemia is a less common genetic disorder attributable to a single genetic mutation. Acquired hypercholesterolemia has many possible causes, and it is the form of hypercholesterolemia that affects most adults. Hypercholesterolemia rarely shows up with symptoms, but its effects can be severe and even life-threatening.
  • What is the difference between high cholesterol and hypercholesterolemia?
    Hyperlipidemia is diagnosed when there are above normal levels of fats (lipids) in the blood, including all the different types of lipids, including triglycerides. Hypercholesterolemia is a condition where there are above normal levels of LDL and total cholesterol in the blood, not including triglycerides.
  • Why is my cholesterol so high but I am healthy?
    High cholesterol can be caused by many different things, including the genes. High cholesterol is very common, but because it doesn't usually show up with specific symptoms, most people don't know they have it until it is detected in a blood test or has already started to cause plaque to build up in the arteries. This can lead to high blood pressure and severe cardiac problems.
  • Does high LDL mean blockage?
    Low-density lipoprotein (LDL) is called bad cholesterol because it can clog the main blood vessels by laying down levels of plaque that block the channels through which blood is pumped. This causes extra pressure, and the heart has to work harder to keep the blood flowing. Eventually, this can lead to heart failure or cause an aneurysm, when a blood vessel bursts under the high pressure.

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