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  • US Name:

    Farxiga

  • Israeli Names:

    Forxiga

  • Active Ingredients:

    Dapagliflozin

  • Brand Manufacturer:

    Astra Zeneca

  • Manufacturer Location:

    USA and UK

Farxiga

Farxiga is an oral medication used to treat type 2 Diabetes and various cardiovascular diseases.

Prescription Required
Forxiga
Brand
5mg
30 Tablets
$140.00
Forxiga
Brand
10mg
30 Tablets
$99.00
*Please note all prices are in US dollars

Farxiga (generic name: dapagliflozin) is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. 

Farxiga acts as a blocker for the SGLT2 protein, which is situated in the early parts of the kidney tubules. Its primary function is to reabsorb the glucose from the filtered liquid back into the body. By doing this, the drug ensures that more glucose is expelled through urine rather than being taken back into the blood.

Beyond its effect on glucose, Farxiga also impacts how the kidneys handle salt. This can lead to several physiological effects, including reducing the workload on the heart, moderating specific body signals, and potentially decreasing the internal pressure within the kidney’s filtering units.

Outcomes include:

  • An improvement in glycemic control in adults with type 2 Diabetes
  • A reduction in the risk of sustained kidney decline 
  • A reduction in the risk of hospitalization for heart failure in adults with diabetes or kidney decline

Dosage

Dosage is dependent on the underlying condition. It is essential to follow the prescribing healthcare professional’s instructions and read the Patient Information leaflet that comes with the package.

Some side effects are reported in the Patient Information leaflet.

  • Vaginal yeast infections in women who experience vaginal odor, white or yellowish vaginal discharge, or vaginal itching. 
  • Yeast infection of the skin around the penis (balanitis)
  • Nasopharyngitis
  • Urinary tract infections. 

If these do not clear up in a few days, or worsen, consult with a physician or pharmacist.

Failure to read and follow the information on the manufacturer’s Product Insert leaflet that comes with the medication can carry serious health risks. Please be aware that not all possible side effects can be listed here. If you experience any of these or any other unexpected side effects, consult with a healthcare provider immediately.

Farxiga is prescribed:

  • as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
  • to reduce the risk of kidney function decline and end-stage kidney disease
  • to reduce the risk of cardiovascular death and hospitalization for heart failure in adults with chronic kidney disease at risk of progression
  • to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visit in adults with heart failure
  • to reduce the risk of hospitalization for heart failure in adults with type 2 diabetes mellitus and either established cardiovascular disease or multiple cardiovascular risk factors.
  • Can Farxiga be used to treat heart failure (HF)?

    Farxiga (dapagliflozin) is approved in the US for adults with heart failure with reduced ejection fraction (HFrEF). Dapagliflozin reduces oxidative stress and can also delay atherosclerosis.
  • Can dapagliflozin be taken without metformin?

    Dapagliflozin and metformin are sometimes prescribed in combination to reduce the risk of kidney disease, cardiovascular damage or heart failure in patients with chronic kidney disease. Dapagliflozin’s effect is to prevent the absorption of glucose in the kidneys. Dapagliflozin is usually prescribed for patients who cannot take metformin, or when metformin is no longer keeping blood sugar level under control.
  • What class of drug is dapagliflozin?

    Farxiga belongs to a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. SGLT2 inhibitors are intended for use with diet and exercise to lower blood sugar in adults with type 2 diabetes. They lower blood sugar levels by causing the kidneys to excrete more glucose in the urine. Farxiga can also be prescribed to prevent heart failure.
  • Does dapagliflozin affect weight?

    Metformin and Farxiga are prescribed together for the treatment of diabetes. Dapagliflozin is associated with mild and sustained weight loss in patients with type 2 diabetes.
  • Can dapagliflozin cause kidney disease?

    SGLT2 inhibitors such as Farxiga (dapagliflozin) can cause acute kidney injury (AKI). Read Farxiga's product label and warnings in the patient guide provided with the medication about the risk of kidney injury.
  • Does Farxiga have cardiovascular benefits?

    Farxiga (dapagliflozin) is approved in the US to reduce the risk of cardiovascular (CV) death, hospitalization for heart failure, and urgent heart failure (HF) visits.
  • Can you drink alcohol while taking dapagliflozin?

    Patients with type 2 diabetes taking Farxiga (dapagliflozin) are generally advised to avoid or strictly limit alcohol intake. Alcohol can cause both hypoglycemia and hyperglycemia in patients with diabetes, depending on the timing and quantity. Hypoglycemia (low sugar) can occur if the consumption of alcohol coincides with taking the medication.

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