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Pimecrolimus is absorbed into the skin, where it works by blocking the production of inflammatory chemicals called cytokines. These are produced by white blood cells in the skin as part of the body’s immune response to allergy or irritation, and are part of a cascade of events in the skin that results in the irritated area becoming inflamed – red, swollen and itchy. As pimecrolimus stops the white blood cells in the skin from producing cytokines, it reduces inflammation in the skin. Pimecrolimus cream is used to reduce the inflammation of the skin seen in eczema (atopic dermatitis). This relieves the symptoms of this condition, such as redness and itching.
Serious side effects from Elidel are rare. However, any symptoms of a serious allergic reaction, such as severe dizziness or trouble with breathing, a rash or itching other than where the cream was applied or swelling of the face, tongue or throat should be reported to your doctor immediately.
Common side effects that should clear up within a few days include mild burning or irritation at the site where the cream was applied. Mild headaches may also occur. If they persist or get worse, report this to your healthcare professional or pharmacist promptly.
Elidel is prescribed to treat the condition known as eczema or atopic dermatitis, especially when other treatments with steroids have failed or are contraindicated. Atopic dermatitis is believed to be an autoimmune condition, where cells in the skin are overreacting to a stimulus and causing inflammation.
It is also used to treat the condition known as vitiligo, where portions of the skin lose their natural color.
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