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Desyrel is a selective serotonin reuptake inhibitor (SSRI) drug approved for treatment of Major Depressive Disorders.

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Trazodone Generic 50mg
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Desryel (generic name: trazodone) is a selective serotonin reuptake inhibitor (SSRI) prescribed for the treatment of Major Depression Disorder (MMD). Trazodone prevents the resorption of serotonin in the nerves. Serotonin is a neurotransmitter that acts to promote messaging between nerve cells. Low serotonin and noradrenaline levels can produce imbalances in brain chemistry and lead to bouts of depression. Desryel can also be prescribed off-label to treat alcohol dependence and insomnia as well as some other depressions..


Doctors will prescribe the appropriate dosage and dosing regime. It is very important that no changes are made to the dose without first consulting with the prescibing doctor or another qualified healthcare professional. Since trazodone can induce drowsiness, it is usually recommended that the dose is taken last thing at night before sleep.

This text is for informational purposes only. Please consult your doctor or pharmacist before using any medication.

Like any medication trazodone can cause side effects in some people, but most people have no side effects. The common side effects are:

  • Feeling excessively sleepy or tired
  • Headaches
  • Gastro upsets (nausea or constipation)
  • A dry mouth

If these side effects do not go away or worsen, consult with a doctor or pharmacist.

Serious side effects

Some rare side effects are serious. If these occur, go at once to a hospital emergency room:

  • if the whites of the eyes turn yellow, or skin turns yellow, which  can be a sign of liver problems
  • extreme constipation or unability to urinate
  • unexplained bruising
  • being liable to get more infections than usual
  • have an abnormal heartbeat
  • have a long-lasting or painful erection that lasts longer than 2 hours (especially when not having sex)
  • have a seizure
  • have suicidal thoughts

Desyrel is approved by the FDA to treat Major Depression Disorder (MDD) in adults.

Depression can be caused by an imbalance of brain chemicals called neurotransmitters. Various contributing factors often have an influence. It can be triggered by life events or certain health conditions. Sometimes it may surface without a cause.

What are the signs of depression?

While symptoms can vary from person to person the key markers of depression include;

  • Feelings of sadness, anxiety or emptiness
  • Loss of interest in activities that were enjoyable
  • Changes in appetite and weight
  • Alterations in sleep patterns like insomnia or oversleeping
  • Slowed physical movements or speech as well as difficulty with thinking
  • Restlessness
  • Increased irritability and agitation
  • Reduced energy levels leading to consistent fatigue or sluggishness
  • Ongoing feelings of worthlessness or excessive guilt
  • Difficulty concentrating or making decisions
  • Recurrent thoughts about death or suicide including suicide attempts (Please seek immediate help if needed)

If you experience five or more of these symptoms for two weeks consecutively you may receive a diagnosis of depression.

Other clinical uses for Desyrel that can be prescribed off-label include;

Treatment for insomnia
Managing panic disorder
Preventing chronic tension type headaches
Supporting those with social anxiety disorder
Treating traumatic stress disorder when used alongside an SSRI medication
Helping manage fibromyalgia symptoms


  • Is trazodone used for mood stabilizer?
    No. Desryel is approved by the FDA to treat depression or anxiety, or a combination of these conditions. It increases the levels of serotonin and noradrenaline and can address symptoms like insomnia and poor concentration.
  • What can Desyrel be used for besides depression?
    Trazodone is only approved for the treatment of Major Depressive Disorder. However, it is widely prescibed off-lable for other disorders, including Generalised Anxiety Disorder, Panic Disorder, Post-Traumatic Stress Disorder, as well as insomnia and alcohol dependence.
  • How long can you stay on trazodone?
    Trazodone is safe for extended use. There are no reported harmful effects from taking it for months, or even years. For people who have recurrent bouts of MDD, it may be necessary to take Desyrel for the rest of their lives.
  • Can trazodone be stopped abruptly?
    Doctors generally recommend that only if necessary, doses can be slowly tapered off, usually over a period of weeks to months. This is because there can be serious withdrawal symptoms from stopping trazodone suddenly.
  • Can I drink alcohol while taking trazodone ?
    Alcohol may increase the bouts of depression and make the side effects worse. It is better to avoid drinking alcohol while being treated with Desyrel.

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