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In the brain there are numerous different chemical compounds called neurotransmitters. These act as chemical messengers between the nerve cells. Serotonin and noradrenaline are neurotransmitters and they have various functions that we know of. Trazodone works by preventing serotonin from being reabsorbed back into the nerve cells in the brain. It may also mimic the mood-lightening effect of released serotonin and enhance a very small degree of noradrenaline release from nerve cells in the brain. This helps enhance and prolong the mood-lightening effect of any released noradrenaline and serotonin. In this way, trazodone helps relieve depression.
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