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Israel Pharm Branded Brands
  • US Name:

    Coralan, Servier

  • Israeli Names:

    Coralan

  • Active Ingredients:

    Ivabradine

  • Brand Manufacturer:

    Servier Laboratories

  • Manufacturer Location:

    France

Coralan, Servier

Ivabradine is a novel treatment for stable angina pectoris.

Coralan (Brand)CoralanBrand7.5mg56 Tablets $110.00
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Coralan (Brand)CoralanBrand5mg56 Tablets $46.66
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  • Description
  • Side Effects
  • Indications

Symptomatic treatment of chronic stable angina pectoris in patients with normal sinus rhythm, who have a contra-indication or intolerance for beta-blockers.

Luminous phenomena (phosphenes) were reported by 14.5% of patients, described as a transient enhanced brightness in a limited area of the visual field. They are usually triggered by sudden variations in light intensity. The onset of phosphenes is generally within the first two months of treatment after which they may occur repeatedly. Phosphenes were generally reported to be of mild to moderate intensity. All phosphenes resolved during or after treatment, of which a majority (77.5%) resolved during treatment. Fewer than 1% of patients changed their daily routine or discontinued the treatment in relation with phosphenes. Bradycardia was reported by 3.3% of patients particularly within the first 2 to 3 months of treatment initiation. 0.5% of patients experienced a severe bradycardia below or equal to 40 bpm.

Symptomatic treatment of chronic stable angina pectoris in patients with normal sinus rhythm, who have a contraindication or intolerance for beta-blockers. For the different doses, film-coated tablets containing 5 mg and 7.5 mg ivabradine are available. The usual recommended starting dose of ivabradine is 5 mg twice daily. After three to four weeks of treatment, the dose may be increased to 7.5 mg twice daily depending on the therapeutic response. If, during treatment, heart rate decreases persistently below 50 beats per minute (bpm) at rest or the patient experiences symptoms related to bradycardia such as dizziness, fatigue or hypotension, the dose must be titrated downward including the possible dose of 2.5 mg twice daily (one half 5 mg tablet twice daily). Treatment must be discontinued if heart rate below 50 bpm or symptoms of bradycardia persist.

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