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  • US Name:


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  • Active Ingredients:

    Brimonidine-0.2% and Timolol-0.5%

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Prescription Required

Combigan eye drops are used to lower intraocular pressure in cases of open-angle glaucoma and ocular hypertension.

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Combigan Brand 0.2%, 0.5%
1 - 5ml Bottle
Our price: $39.00

*Please note all prices are in US dollars
Combigan (brimonidine and timolol) is prescribed to treat patients with raised intraocular pressure (IOP) due to glaucoma or ocular hypertension (OHT). Brimonidine belongs to a group of medicines called alpha-adrenergic receptor agonists, and timolol belongs to a group of medicines called beta-blockers. They are both medicines that decrease intraocular pressure and have a combined effect that is greater than either medicine on its own.


Use only according to the doctor’s instructions. The usual dosage is one drop in the affected eye(s) twice daily, approximately 12 hours apart.
To administer the drops, after washing hands, tilt the head back and pull the lower lid downward to create a pocket. Insert the required number of drops into this pocket, close the eyes gently and do not open or blink for one to two minutes. Try to avoid touching the surface of the eye or surrounding skin, to avoid transferring any possible infection.

This text is for informational purposes only. Please consult a doctor or pharmacist before using any medication. 

Read the information leaflet that comes with the medication.

Most people who use Combigan do not experience any negative side effects. Doctors prescribe Combigan because they assess that the benefits that such treatment yields outweighs any likely unwanted effects.

Some of the side effects that have been reported include red or enlarged blood vessels in the front of the eye, burning, stinging or itching sensations immediately after inserting the drops (probably due to an allergic reaction), inflammation of the eyelid, visual disturbances, or a sensation of a foreign body or grittiness, eye discharge.

Not all side effects are listed here. If these or other unlisted symptoms persist or worsen, consult a healthcare provider or pharmacist.

Combigan is used to treat raised intraocular pressure that could be the result of open-angle glaucoma or ocular hypertension. The symptoms of glaucoma and ocular hypertension may be mild or go completely unnoticed. When the IOP is advanced, it can cause pain in and around the eye, blurred vision or blind spots. The only proper diagnosis comes from the measurement of intraocular pressure that can be performed by a healthcare provider or optometrist with specialized equipment.

Most doctors will prescribe treatment if pressures are consistently higher than 28-30 mmHg because this indicates a risk of optic nerve damage.

  • What age can you use brimonidine? Why is brimonidine contraindicated in children?
    The safety and efficacy of Combigan (brimonidine 0.2%/timolol 0.5%) as a treatment for glaucoma in children have not yet been established. Combigan eye drops should not be used in children aged twelve years or younger. The basic reason is that brimonidine can pass through the blood-brain barrier. This creates the potential to cause CNS toxicity. There have been reports of bradycardia, hypothermia, hypotension, hypotonia, and apnea in infants.
  • Does brimonidine change your eye color?
    Studies have shown that between five percent and fifteen percent of people treated with brimonidine displayed a gradual change in eye color in the treated eye. This is due to an increased deposit of brown pigment in the iris. The change of color occurs slowly and may only be noticeable after several months or even years.
  • Is sleep a side effect of brimonidine?
    Combigan has been reported as causing some people to become lightheaded or less alert than they are normally. There can also be side effects of dizziness or drowsiness, with people feeling tired unexpectedly. The advice included in the patient leaflet is to not drive or do anything else that could be dangerous until all side effects of this medication are resolved.
  • Can you use brimonidine long term?
    Glaucoma cannot be cured, but early treatment, such as with Combigan, can often stop the damage and protect vision. Brimonidine can be used safely and reliably to reduce IOP (intra-ocular pressure) in glaucoma and ocular hypertension (OHT), and it may also reduce the risk of glaucoma progressing regardless of its effects on IOP. Research has shown that unlike an alternative treatment for glaucoma, such as apraclonidine, long-term use of brimonidine does not induce a high incidence of ocular allergy.
  • Can you drink alcohol while using brimonidine?
    It is strongly advised to avoid or strictly limit drinking alcohol while using Combigan. Alcohol while using this medication has been reported to cause dizziness, drowsiness, and difficulty concentrating and can increase the risk of falling. It can also result in more serious effects, such as central nervous system (CNS) depression,

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