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  • US Name:


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  • Active Ingredients:

    Brimonidine-0.2% and Timolol-0.5%

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Combigan is a combination therapy for Glaucoma.

Prescription Required
0.2%, 0.5%
1 - 5ml Bottle
*Please note all prices are in US dollars

Combigan eye drops contain two active ingredients, brimonidine tartrate and timolol maleate. These are both medicines that decrease raised pressure within the eye. They work in different ways to produce a combined effect greater than either medicine produces on its own.

As with any medicine, use of Combigan may cause side effects in some users. Do not be alarmed by
the list of side effects. You may not experience any of them.
In clinical trials of 12 months duration with COMBIGAN®, the most frequent reactions associated
with its use occurring in approximately 5% to 15% of the patients included:
• red enlarged blood vessels in the eye
• burning sensation
• stinging sensation
• itchy eye
• allergic reaction in the eye
• inflammation of the eyelid
The following adverse reactions were reported in 1% to 5% of patients:
• watery eyes
• redness of the inner surface of the eye and eyelid
• eye pain
• eye dryness
• visual disturbance
• foreign body sensation in the eye
• eye discharge
• swollen eyelid
• itchy eyelid
• eye irritation
• Small abrasions of the surface of the eye
• headache
• feeling weak
• depression
• high blood pressure
• dry mouth
• feeling drowsy.

Combigan is used to reduce high pressure in the eye in patients with open-angle glaucoma or ocular hypertension. The medicine contains two active ingredients: brimonidine, which belongs to a group of medicines called alpha-adrenergic receptor agonists, and timolol which belongs to a group of medicines called beta-blockers. Both of these active ingredients reduce pressure in the eye.

  • What age can you use brimonidine? Why is brimonidine contraindicated in children?

    The safety and efficacy of Combigan (brimonidine 0.2%/timolol 0.5%) as a treatment for glaucoma in children have not so far been established. Combigan eye drops should not be used in children aged twelve years or younger. The basic reason is that brimonidine can pass through the blood-brain barrier. This creates the potential to cause CNS toxicity. There have been reports of bradycardia, hypothermia, hypotension, hypotonia, and apnea in infants.
  • Does brimonidine change your eye color?

    Studies have shown that between five percent and fifteen percent of people treated with brimonidine displayed a gradual change in eye color in the treated eye. This is due to an increased deposit of brown pigment in the iris. The change of color occurs slowly and may only be noticeable after several months or even years.
  • Is sleep a side effect of brimonidine?

    Combigan has been reported as causing some people to become lightheaded or less alert than they are normally. There can also be side effects of dizziness or drowsiness, with people feeling tired unexpectedly. The advice included in the patient leaflet is to not drive or do anything else that could be dangerous until all side effects of this medication are resolved.
  • Can you use brimonidine long term?

    Glaucoma cannot be cured, but early treatment, such as with Combigan, can often stop the damage and protect vision. Brimonidine can be used safely and reliably to reduce IOP (intra-ocular pressure) in glaucoma and ocular hypertension (OHT), and it may also reduce the risk of glaucoma progressing regardless of its effects on IOP. Research has shown that unlike an alternative treatment for glaucoma, such as apraclonidine, long-term use of brimonidine does not induce a high incidence of ocular allergy.
  • Can you drink alcohol while using brimonidine?

    It is strongly advised to avoid or strictly limit drinking alcohol while using Combigan. Alcohol while using this medication has been reported to cause dizziness, drowsiness, and difficulty concentrating and can increase the risk of falling. It can also result in more serious effects, such as central nervous system (CNS) depression,


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