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For visual reference only; actual product may vary
For visual reference only; actual product may vary
Calquence (acalabrutinib) is an advanced oral chemotherapy medication used to treat specific types of non-Hodgkin lymphoma, including mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL). It works by blocking a key enzyme involved in cancer cell growth, helping to slow the progression of the disease.
| Calquence Brand | 100mg 56 Capsules |
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Our price: $5,000.00 |
Calquence is a targeted therapy medication used to treat certain types of B-cell cancers, such as mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), and small lymphocytic lymphoma (SLL). As an oral chemotherapy drug containing the active ingredient acalabrutinib, it offers a modern approach to cancer treatment. Manufactured by AstraZeneca, Calquence is prescribed for adults, often as a second-line treatment for MCL after at least one prior therapy has been attempted, or as a primary or subsequent treatment for CLL and SLL. It is designed to specifically target cancer cells, minimizing damage to surrounding healthy cells.
Calquence works by selectively blocking an enzyme called Bruton’s tyrosine kinase (BTK), which is crucial for the survival and growth of malignant B-cells. In cancers like CLL and MCL, BTK is overactive, sending constant signals that tell cancer cells to multiply and survive. Acalabrutinib, the active ingredient in Calquence, is a highly selective BTK inhibitor. By binding to and blocking this enzyme, it interrupts the signaling pathway, which in turn leads to the death of the cancer cells (a process known as apoptosis) and helps to control the spread of the lymphoma.
Calquence is primarily for adults diagnosed with specific B-cell cancers, including mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), or small lymphocytic lymphoma (SLL). It is specifically indicated for MCL patients who have already undergone at least one other treatment. For those with CLL or SLL, Calquence may be prescribed as an initial (first-line) therapy or as a treatment following other therapies. It is a suitable option for patients who require an oral, targeted medication and can be managed in an outpatient setting under the supervision of an oncologist. This medication is not intended for use in children.
The standard dosage for Calquence is typically one 100 mg capsule taken orally twice daily, approximately 12 hours apart. You should swallow the capsules whole with a full glass of water; do not crush, chew, or open them. If you take heartburn medications like antacids, they must be administered at least two hours before or two hours after your Calquence dose. If you forget a dose, take it as soon as you remember if it has been three hours or less. If more than three hours have passed, skip the missed dose and resume your normal schedule. Never take a double dose to make up for a missed one. Your oncologist will determine your exact regimen.
While many people tolerate Calquence well, common side effects can include headache, diarrhea, muscle and joint pain, bruising, fatigue, and nausea. These symptoms are often mild and manageable. However, more serious side effects can occur and require immediate medical attention. A significant risk is bleeding, so any signs like blood in stool or urine, coughing up blood, or unusual bleeding should be reported to your doctor. Other serious risks include an increased chance of infections, the development of new cancers (particularly skin cancer), and heart rhythm problems like atrial fibrillation. Always discuss any persistent or concerning symptoms with your healthcare provider.
IsraelPharm offers a reliable and cost-effective way to access genuine Calquence (Acalabrutinib) manufactured by AstraZeneca, delivered directly to your home. We are committed to providing affordable access to brand-name medications by sourcing them through our licensed international pharmacy network. By choosing IsraelPharm, you benefit from significant savings compared to typical US prices without compromising on quality or safety. Our convenient online ordering process, discreet worldwide shipping, and dedicated customer support team ensure you receive your vital medication with ease and confidence.
Most individuals do not experience severe side effects. The most commonly reported side effects include:
In rare cases, more serious side effects can occur and require immediate medical attention. These include:
This is not a complete list. Always consult your doctor about potential risks and side effects.
Calquence (acalabrutinib) is indicated for the treatment of adult patients with:
It is a targeted therapy that helps manage these forms of non-Hodgkin lymphoma by inhibiting cancer cell growth.
The timeframe for Calquence to show effects can vary. Some patients may notice an improvement in symptoms or blood counts within a few months, but it can take longer for the full benefits to be realized. Your oncologist will monitor your progress through regular check-ups and lab tests to evaluate the drug's effectiveness for your specific condition.
Yes, Calquence can be taken with or without food. However, it is important to be consistent in how you take it each day. Swallow the capsules whole with a glass of water. Do not open, break, or chew the capsules, as this can affect how the medication is absorbed by your body and its overall effectiveness.
If you miss a dose of Calquence by three hours or less, take it as soon as you remember. If it has been more than three hours, skip the missed dose and take your next dose at the regularly scheduled time. Do not take two doses at the same time to make up for a missed one.
You should avoid consuming grapefruit, grapefruit juice, and Seville oranges (often found in marmalade) while taking Calquence. These products can interfere with the breakdown of the drug in your body, leading to increased levels in your blood and a higher risk of side effects. Always discuss your diet with your doctor or pharmacist.
It is generally recommended to limit or avoid alcohol consumption while undergoing cancer treatment with medications like Calquence. Alcohol can potentially worsen side effects such as nausea, fatigue, or liver problems. It is best to consult with your healthcare provider about whether any amount of alcohol is safe for you during your treatment period.
Calquence should be stored at room temperature, away from excessive heat, moisture, and direct sunlight. Keep the bottle tightly closed and out of the reach of children and pets. Do not store it in the bathroom, as the humidity can damage the medication. Follow the storage instructions provided on the packaging for best results.
Both Calquence (acalabrutinib) and Imbruvica (ibrutinib) are BTK inhibitors used for similar cancers. However, Calquence is considered a more selective, next-generation inhibitor. This selectivity may lead to fewer off-target side effects for some patients compared to Imbruvica. Your oncologist will determine which medication is more appropriate for your specific health profile.
It is crucial to inform your doctor about all medications you are taking, including over-the-counter drugs, antacids, and supplements, as some can interact with Calquence. For example, acid-reducing agents like Tums or Tagamet must be taken at least two hours apart from your Calquence dose to ensure proper absorption.
Unlike many traditional chemotherapy drugs, hair loss is not a common side effect of Calquence. As a targeted therapy, it works differently by focusing on specific cancer cells, which generally results in a different side effect profile. While some patients may experience mild thinning, significant hair loss is rare with this medication.
You should talk to your doctor before receiving any vaccinations while on Calquence. Live vaccines should be avoided as this medication can affect your immune system, potentially making these vaccines unsafe or less effective. Non-live vaccines, such as the flu shot, are usually considered safe, but it's essential to get medical clearance from your oncologist.
Calquence works on B-cells, which are a component of your immune system. While it targets cancerous B-cells, it can also affect healthy ones, potentially increasing your risk of infections. Your doctor will monitor your blood counts closely. It's important to practice good hygiene and report any signs of infection, such as fever or sore throat, immediately.
You may need to temporarily stop taking Calquence before and after a planned surgery or dental procedure due to an increased risk of bleeding. Always inform your doctor and surgeon that you are on this medication well in advance of any scheduled procedure. They will provide specific instructions on when to stop and restart the drug.
Calquence can increase your risk of bleeding. If you experience any signs of serious bleeding, such as blood in your stool or urine, coughing up blood, severe bruising, or bleeding that won't stop, contact your doctor immediately or seek emergency medical care. This is a potentially serious side effect that requires prompt medical evaluation.
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