Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing, swelling of your face, lips, tongue, or throat. Stop using diclofenac and misoprostol and call your doctor at once if you have a serious side effect such as: Chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance, black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds, swelling or rapid weight gain, urinating less than usual or not at all, increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure), nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes), pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating, bruising, severe tingling, numbness, pain, muscle weakness, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions); or severe skin reaction — fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Less serious side effects may include: Mild stomach pain, nausea, diarrhea, bloating, gas, dizziness, drowsiness, headache, blurred vision, ringing in your ears or unusual vaginal bleeding.
Carefully consider the potential benefits and risks of ARTHROTEC and other treatment options before deciding to use ARTHROTEC. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals. ARTHROTEC is indicated for treatment of the signs and symptoms of osteoarthritis or rheumatoid arthritis in patients at high risk of developing NSAID-induced gastric and duodenal ulcers and their complications. See WARNINGS, Gastrointestinal Effects – Risk of Ulceration, Bleeding, and Perforation for a list of factors that may increase the risk of NSAID-induced gastric and duodenal ulcers and their complications.