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  • Active Ingredients:

    Estradiol and Norethisterone

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Activella is used in the treatment of the symptoms of menopause and other hormone-related issues.

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Activelle Brand 1mg / 0.5mg
28 Tablets
Our price: $37.00

*Please note all prices are in US dollars
Activella (estradiol and norethisterone) is a form of Hormone Replacement Therapy (HRT.) Estrogen is the main hormone that is involved in the development and maintenance of the female reproductive system. Norethindrone is a form of progesterone, a hormone important for regulating ovulation and menstruation. Together, estradiol and norethindrone are used to treat the symptoms of menopause. It can also be prescribed to boost estrogen levels in conditions such as hypogonadism, after removal of the ovaries, or primary ovarian failure. Estradiol and norethindrone are also used to prevent thinning of the bones (osteoporosis).
Estradiol increases the risk of developing endometrial hyperplasia, a condition that may lead to cancer of the lining of the uterus. That is why Activella combines estradiol with norethindrone, which is a progestin that lowers the risk of developing this condition.

This text is for informational purposes only. Please consult your doctor or pharmacist before using any medication.

Activella can cause some of the following side effects:

  • nausea and vomiting
  • tenderness or enlargement of the breasts
  • weakness
  • swelling of the hands or feet
  • spotty darkening of the skin, particularly on the face
  • difficulty in wearing contact lenses
  • vaginal irritation or discomfort
  • changes in the menstrual cycle, painful menstruation, or breakthrough bleeding.

Continue to take Activella and talk to a doctor if these or other side effects persist or worsen.

Visit a doctor regularly and report any unusual vaginal bleeding right away.

If you experience any of the following serious side effects, stop taking Activella and seek emergency medical attention or notify your doctor immediately:

Activella can sometimes cause an allergic reaction, with symptoms like difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; hives; shortness of breath or pain in the chest; a red, painful and swollen leg; abnormal vaginal bleeding; pain, swelling, or tenderness in the abdomen; severe headache; vomiting; dizziness, faintness or changes in vision or speech; yellowing of the skin or eyes, or a lump in a breast.

If you experience any of the following serious side effects, stop taking Activella and seek emergency medical attention immediately.

Activella is prescribed to treat the following symptoms in menopausal women:

  • Moderate to severe hot flashes and night sweats (vasomotor symptoms)
  • Moderate to severe symptoms of vulvar and vaginal atrophy.

Activella is also used to prevent postmenopausal weakening of the bones (osteoporosis).

  • What are the three stages of menopause?
    Menopause is divided into three stages: perimenopause begins when the ovaries begin to atrophy, causing a decline in the production of the hormones estrogen and progesterone that stimulate the menstrual cycle. Monthly periods become irregular, and after they cease for 12 months, the stage of full menopause is reached. Postmenopause continues for the rest of a woman's life, during which symptoms can continue or abate.
  • What are the signs of low estrogen levels?
    The main signs of low estrogen include dry skin; tender breasts; weak or brittle bones due to osteoporosis; moodiness and irritability; vaginal dryness or atrophy; hot flashes and night sweats.
  • Is Activella a hormone replacement therapy?
    Yes. Activella is a combination containing both estrogen and progestin and is a hormone replacement therapy (HRT).
  • Why am I aging so quickly after menopause?
    Menopause is a result of lowering of estrogen layers that comes with aging. It can result in skin changes leading to the acceleration of skin aging. Estrogen levels modulate skin physiology, influencing the subcutaneous layers as well as hair follicles and sebaceous glands.

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