This text is for informational purposes only. Please consult your doctor or pharmacist before using any medication.

Activella can cause some of the following side effects:

• nausea and vomiting
• tenderness or enlargement of the breasts
• weakness
• swelling of the hands or feet
• spotty darkening of the skin, particularly on the face
• difficulty in wearing contact lenses
• vaginal irritation or discomfort
• changes in the menstrual cycle, painful menstruation, or breakthrough bleeding.

Continue to take Activella and talk to a doctor if these or other side effects persist or worsen.

Visit a doctor regularly and report any unusual vaginal bleeding right away.

If you experience any of the following serious side effects, stop taking Activella and seek emergency medical attention or notify your doctor immediately:

Activella can sometimes cause an allergic reaction, with symptoms like difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; hives; shortness of breath or pain in the chest; a red, painful and swollen leg; abnormal vaginal bleeding; pain, swelling, or tenderness in the abdomen; severe headache; vomiting; dizziness, faintness or changes in vision or speech; yellowing of the skin or eyes, or a lump in a breast.

If you experience any of the following serious side effects, stop taking Activella and seek emergency medical attention immediately.

Activella is prescribed to treat the following symptoms in menopausal women:

• Moderate to severe hot flashes and night sweats (vasomotor symptoms)
• Moderate to severe symptoms of vulvar and vaginal atrophy.

Activella is also used to prevent postmenopausal weakening of the bones (osteoporosis).