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Vfend is a drug that prevents the spread of fungal infections. Vfend is intended mainly for patients with worsening and possibly life-threatening infections such as invasive aspergillosis or candida-resistant infections, infection by fusarium or scedosporium fungus, or invasive fungal infections following bone marrow transplants.

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Vfend (generic name: voriconazole) is an antifungal drug from the triazole family that prevents fungal growth of opportunistic human Candida-based yeast pathogens that cause infections when the host is immunocompromised or debilitated. Triazole acts to disrupt the formation of ergosterol, an essential component of fungal cell membranes. Without a functional cell membrane, the fungus is prevented from spreading.

Candida fungal infections are often life-threatening.

Vfend is used for the treatment of adults and children over the age of two who have one of the following fungal infections:

  • invasive aspergillosis 
  • candidemia in patients with a normal white blood cell count
  • infections caused by candida that is resistant to fluconazole (an alternate antifungal medicine)
  • infections caused by scedosporium or fusarium fungus

Vfend is intended mainly for patients with worsening and possibly life-threatening infections or to prevent invasive fungal infections in patients who have undergone a hematopoietic stem-cell transplant and are at high risk of infection.

This medication has been prescribed because your healthcare provider has judged that the benefits are greater than the risk of side effects. Many people using this medication do not have serious side effects. 

Severe side effects can include:

  • Vision changes
  • Fever
  • Blood tests showing high levels of bilirubin, alanine transaminase or aspartate transaminase, or abnormal liver functions
  • Accelerated heartbeat.

If experienced, they should be reported to your healthcare provider as soon as possible.

Other common side effects include:

  • chills
  • nausea or vomiting
  • fluid retention or swelling of the limbs
  • chest pain
  • dry mouth, inflammation of the lips
  • headache
  • diarrhea
  • abdominal pain
  • bumpy skin rash
  • visual sensitivity to light

If these persist after a few days or worsen, you should report them to your pharmacist or healthcare provider.

Candida yeast is found widely in many parts of the body (such as the oral cavity, gastrointestinal tract, vagina or penis) but only a few species are opportunistic human pathogens that cause infections when the host is immunocompromised or debilitated. Invasive fungal infections are often life-threatening,

Vfend is intended for the treatment of such severe and dangerous fungal infections of the following types:

  • candidiasis fungal infection, especially of the oropharynx or esophagus 
  • candida yeast in the blood
  • systemic aspergillosis fungal infection 
  • febrile neutropenia (patients with fever where the level of white blood cells is reduced)
  • infection caused by scedosporium apiospermum fungus, or fusarium fungus
  • histoplasmosis fungal lung infection 

Candidiasis occurs most commonly as a secondary infection in immunocompromised individuals.


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