How does Simponi benefit patients with ulcerative colitis?

Ulcerative colitis (UC) is a chronic inflammatory bowel disease causing inflammation and ulcers in the lining of the large intestine. Simponi is prescribed for adults with moderately to severely active UC who have had an inadequate response to other therapies, aiming to induce and maintain clinical remission, achieve mucosal healing, and eliminate corticosteroid use

What are TNF blockers, and how do they work?

TNF blockers are medications that inhibit the activity of tumor necrosis factor-alpha (TNF-alpha), a substance in the body that causes inflammation. By blocking TNF-alpha, these drugs help reduce inflammation associated with various autoimmune conditions.

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US Name:

Simponi
Alternative Names:

Simponi
Active Ingredients:

Golimumab
Brand Manufacturer:

Janssen
Manufacturer Location:
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Simponi ^*

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Simponi helps reduce inflammation and modulate abnormal immune responses in several chronic inflammatory diseases, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis.

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Simponi Brand	50mg 1 Pre-Filled Pen	- Simponi – Brand, Simponi, 50mg, 1, Pre-Filled Pen, 29028, Cilag, 3908 + 0	Our price: $1,570.00
Simponi Brand	50mg 1 Pre-Filled Syringe	- Simponi – Brand, Simponi, 50mg, 1, Pre-Filled Syringe, 31568, Cilag, 3909 + 0	Our price: $1,570.00
Simponi Brand	100mg 1 Autoinjector Pen	- Simponi – Brand, Simponi, 100mg, 1, Autoinjector Pen, 85391, Cilag, 3910 + 0	Our price: $1,865.00

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Description
Side Effects
Indications
FAQ
Video

Simponi (generic name: golimumab) is a prescription medication classified as a tumor necrosis factor (TNF) blocker. It is designed to manage certain autoimmune conditions by inhibiting the activity of TNF-alpha, a substance in the body that causes inflammation. By targeting and neutralizing TNF-alpha, Simponi helps reduce inflammation and modulate abnormal immune responses. This medication is utilized in the treatment of several chronic inflammatory diseases:

Rheumatoid arthritis (RA)
Psoriatic arthritis (PsA)
Ankylosing spondylitis (AS)
Ulcerative colitis (UC).

By inhibiting TNF-alpha, Simponi plays a crucial role in controlling the inflammatory processes underlying these conditions, thereby improving patients’ quality of life and functional abilities.

Usual Dosage(s) and Mode(s) of Administration

Simponi is administered as a subcutaneous injection, allowing patients to self-administer the medication after proper training. The dosing schedule varies based on the specific condition being treated but generally involves once-monthly injections, providing a convenient treatment option for individuals managing chronic inflammatory diseases. The dosing regimen varies depending on the specific condition being treated:

Rheumatoid arthritis (RA): The recommended dose is 50 mg once a month, in combination with methotrexate.
Psoriatic arthritis (PsA): A 50 mg dose is administered once a month, which can be used alone or with methotrexate.
Ankylosing spondylitis (AS): Patients receive 50 mg once a month.
Ulcerative colitis (UC): The induction regimen starts with 200 mg at week 0, followed by 100 mg at week 2. For maintenance, 100 mg is administered every 4 weeks.

Patients are usually trained on the proper injection technique by a healthcare professional before self-administration. It’s important to rotate injection sites to avoid skin irritation. If a dose is missed, patients should inject the missed dose as soon as they remember and then continue with their regular monthly schedule. However, if the next dose is less than two weeks away, they should wait until the next scheduled dose.

Storage Guidelines

Simponi should be stored in a refrigerator at temperatures between 36°F to 46°F (2°C to 8°C). Do not freeze the medication. Keep the prefilled syringe or autoinjector in its original carton to protect it from light until the time of use. If needed, Simponi can be stored at room temperature, up to 77°F (25°C), for a maximum period of 30 days. Once stored at room temperature, it should not be returned to the refrigerator and must be discarded if not used within the 30-day period.

Common Questions About Simponi

How is Simponi administered?

Simponi is administered as a subcutaneous injection, typically once a month. Patients or caregivers are trained to perform the injections at home. It’s important to follow the dosing schedule prescribed by a healthcare provider.

Can golimumab be used during pregnancy or breastfeeding?

The effects of golimumab on pregnant or breastfeeding women are not well-studied. It’s essential to discuss potential risks and benefits with a healthcare provider.

What is rheumatoid arthritis, and how does Simponi help?

Rheumatoid arthritis (RA) is an autoimmune disorder causing inflammation in the joints, leading to pain, swelling, and potential joint damage. Simponi helps reduce these symptoms and slows disease progression by inhibiting TNF-alpha.

This text is for informational purposes only. Please consult a doctor or pharmacist before using any medication.

Read the information leaflet that comes with the medication.

Most people who use Simponi do not experience any adverse side effects. Doctors prescribe this medication because they assess the benefits of such treatment outweigh any likely unwanted effects.

Some of the side effects that have been reported include:

Upper respiratory tract Infections, with symptoms including cough, nasal congestion, and sore throat.
Injection site reactions such as redness, itching, pain, or swelling at the injection site.

Simponi can lower the immune system’s ability to fight infections, leading to serious infections such as tuberculosis, bacterial sepsis, invasive fungal infections, and others. Patients are normally tested for latent tuberculosis before starting treatment.

Not all side effects are listed here. If these or other unlisted symptoms persist or worsen, consult a healthcare provider or pharmacist.

Simponi is approved for the treatment of several autoimmune conditions:

Rheumatoid arthritis: An autoimmune disorder causing inflammation in the joints, leading to pain, swelling, and potential joint damage. Symptoms include tender, warm, swollen joints, morning stiffness, and fatigue. Simponi, in combination with methotrexate, helps reduce these symptoms and slows disease progression.
Psoriatic arthritis: A form of arthritis affecting some individuals with psoriasis, characterized by joint pain, stiffness, and swelling. Simponi is used to alleviate these symptoms and prevent further joint damage.
Ankylosing spondylitis: A chronic inflammatory disease primarily affecting the spine and sacroiliac joints, leading to pain and stiffness. Simponi is approved for the treatment of active AS to reduce symptoms and improve physical function.
Ulcerative colitis: A chronic inflammatory bowel disease causing inflammation and ulcers in the lining of the large intestine. Simponi is prescribed for adults with moderately to severely active UC who have had an inadequate response to other therapies, aiming to induce and maintain clinical remission, achieve mucosal healing, and eliminate corticosteroid use.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease causing inflammation and ulcers in the lining of the large intestine. Simponi is prescribed for adults with moderately to severely active UC who have had an inadequate response to other therapies, aiming to induce and maintain clinical remission, achieve mucosal healing, and eliminate corticosteroid use

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